Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schulz JB et al. | Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. | 1996 | J. Neurochem. | pmid:8667023 |
Greene JG and Greenamyre JT | Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. | 1996 | J. Neurochem. | pmid:8592134 |
Pang Z et al. | Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. | 1996 | J. Neurochem. | pmid:8592116 |
Spetale MR et al. | The effect of organophosphorus compounds on respiration by rat liver mitochondria. | 1977 | Farmaco Sci | pmid:858381 |
Mattson MP et al. | Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. | 1995 | J. Neurosci. Res. | pmid:8583504 |
Zeevalk GD et al. | Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. | 1995 | J. Pharmacol. Exp. Ther. | pmid:8531072 |
Demchuk ML et al. | [Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]. | 1993 Mar-Apr | Vopr. Med. Khim. | pmid:8511880 |
Brand MD et al. | Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. | 1993 | Biochem. J. | pmid:8489502 |
Cox DA and Matlib MA | A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. | 1993 | J. Biol. Chem. | pmid:8419373 |
Taylor RW et al. | Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. | 1993 | Biochim. Biophys. Acta | pmid:8391327 |
Greene JG et al. | Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. | 1993 | J. Neurochem. | pmid:8360680 |
Perez J and Jeffries TW | Role of organic acid chelators in manganese regulation of lignin degradation by Phanerochaete chrysosporium. | 1993 | Appl. Biochem. Biotechnol. | pmid:8323262 |
Davydov VV and FreÄdin MI | [The effect of malonic acid on the rate of fibroblast proliferation in culture]. | 1993 | Tsitologiia | pmid:8322417 |
Valla A et al. | [Descriptive modeling of the chemical structure-biological activity relations of a group of malonic polyethylenic acids as shown by different pharmacotoxicologic tests]. | 1993 | Pharmazie | pmid:8321881 |
Windsor DP and White IG | Assessment of ram sperm mitochondrial function by quantitative determination of sperm rhodamine 123 accumulation. | 1993 | Mol. Reprod. Dev. | pmid:8286118 |
Muralikrishna C and Renganathan V | Peroxidase-catalyzed desulfonation of 3,5-dimethyl-4-hydroxy and 3,5-dimethyl-4-aminobenzenesulfonic acids. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267618 |
Karuri AR et al. | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. | 1993 | Br. J. Cancer | pmid:8260358 |
Parmentier GG et al. | Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases. | 1993 | Steroids | pmid:8212084 |
Medeiros MH et al. | Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. | 1994 | Arch. Biochem. Biophys. | pmid:8161206 |
Jay D et al. | Inhibition of membrane-bound succinate dehydrogenase by fluorescamine. | 1993 | J. Bioenerg. Biomembr. | pmid:8144496 |