Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Neoplasms D009369 13 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Abscess D000038 13 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Alzheimer Disease D000544 76 associated lipids
Teratoma D013724 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Nerve Degeneration D009410 53 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Insulin Resistance D007333 99 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Neoplasms, Muscle Tissue D009379 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Schulz JB et al. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. 1996 J. Neurochem. pmid:8667023
Greene JG and Greenamyre JT Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. 1996 J. Neurochem. pmid:8592134
Pang Z et al. Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. 1996 J. Neurochem. pmid:8592116
Spetale MR et al. The effect of organophosphorus compounds on respiration by rat liver mitochondria. 1977 Farmaco Sci pmid:858381
Mattson MP et al. Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. 1995 J. Neurosci. Res. pmid:8583504
Zeevalk GD et al. Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. 1995 J. Pharmacol. Exp. Ther. pmid:8531072
Demchuk ML et al. [Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]. 1993 Mar-Apr Vopr. Med. Khim. pmid:8511880
Brand MD et al. Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. 1993 Biochem. J. pmid:8489502
Cox DA and Matlib MA A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. 1993 J. Biol. Chem. pmid:8419373
Taylor RW et al. Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. 1993 Biochim. Biophys. Acta pmid:8391327
Greene JG et al. Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. 1993 J. Neurochem. pmid:8360680
Perez J and Jeffries TW Role of organic acid chelators in manganese regulation of lignin degradation by Phanerochaete chrysosporium. 1993 Appl. Biochem. Biotechnol. pmid:8323262
Davydov VV and FreÄ­din MI [The effect of malonic acid on the rate of fibroblast proliferation in culture]. 1993 Tsitologiia pmid:8322417
Valla A et al. [Descriptive modeling of the chemical structure-biological activity relations of a group of malonic polyethylenic acids as shown by different pharmacotoxicologic tests]. 1993 Pharmazie pmid:8321881
Windsor DP and White IG Assessment of ram sperm mitochondrial function by quantitative determination of sperm rhodamine 123 accumulation. 1993 Mol. Reprod. Dev. pmid:8286118
Muralikrishna C and Renganathan V Peroxidase-catalyzed desulfonation of 3,5-dimethyl-4-hydroxy and 3,5-dimethyl-4-aminobenzenesulfonic acids. 1993 Biochem. Biophys. Res. Commun. pmid:8267618
Karuri AR et al. Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. 1993 Br. J. Cancer pmid:8260358
Parmentier GG et al. Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases. 1993 Steroids pmid:8212084
Medeiros MH et al. Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. 1994 Arch. Biochem. Biophys. pmid:8161206
Jay D et al. Inhibition of membrane-bound succinate dehydrogenase by fluorescamine. 1993 J. Bioenerg. Biomembr. pmid:8144496