Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Neoplasms D009369 13 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Abscess D000038 13 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Alzheimer Disease D000544 76 associated lipids
Teratoma D013724 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Nerve Degeneration D009410 53 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Insulin Resistance D007333 99 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Neoplasms, Muscle Tissue D009379 2 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Chin CK and Lee M Effect of pH on the Activity of Some Respiratory Inhibitors. 1980 Plant Physiol. pmid:16661576
Stumpf DK and Burris RH Organic Acid contents of soybean: age and source of nitrogen. 1981 Plant Physiol. pmid:16662077
Stumpf DK and Burris RH Biosynthesis of malonate in roots of soybean seedlings. 1981 Plant Physiol. pmid:16662078
Duggan JX et al. Catabolism of 5-Aminolevulinic Acid to CO(2) by Etiolated Barley Leaves. 1982 Plant Physiol. pmid:16662156
Burke JJ et al. Succinate dehydrogenase : a partial purification from mung bean hypocotyls and soybean cotyledons. 1982 Plant Physiol. pmid:16662722
Chappell J and Beevers H Transport of dicarboxylic acids in castor bean mitochondria. 1983 Plant Physiol. pmid:16663021
Reibach PH and Streeter JG Metabolism of C-labeled photosynthate and distribution of enzymes of glucose metabolism in soybean nodules. 1983 Plant Physiol. pmid:16663058
Kennedy RA et al. Germination of Echinochloa crus-galli (Barnyard Grass) Seeds under Anaerobic Conditions : Respiration and Response to Metabolic Inhibitors. 1983 Plant Physiol. pmid:16663086
Davis LC and Nordin P Sugar and organic Acid constituents in white clover. 1983 Plant Physiol. pmid:16663119
Mukherjee KD Lipid biosynthesis in developing mustard seed: formation of triacylglycerols from endogenous and exogenous Fatty acids. 1983 Plant Physiol. pmid:16663345
Oliver DJ and Walker GH Characterization of the transport of oxaloacetate by pea leaf mitochondria. 1984 Plant Physiol. pmid:16663855
Rawsthorne S and Larue TA Metabolism under Microaerobic Conditions of Mitochondria from Cowpea Nodules. 1986 Plant Physiol. pmid:16664950
Streeter JG Carbohydrate, organic Acid, and amino Acid composition of bacteroids and cytosol from soybean nodules. 1987 Plant Physiol. pmid:16665774
Zoglowek C et al. Oxaloacetate and malate transport by plant mitochondria. 1988 Plant Physiol. pmid:16666083
Martins IS et al. Effect of the electrochemical proton gradient and anions on the ATPase activity of soybean submitochondrial particles. 1988 Plant Physiol. pmid:16666151
Kumar PA et al. Glycine supports in vivo reduction of nitrate in barley leaves. 1988 Plant Physiol. pmid:16666483
Willeford KO et al. Evidence for Chloroplastic Succinate Dehydrogenase Participating in the Chloroplastic Respiratory and Photosynthetic Electron Transport Chains of Chlamydomonas reinhardtii. 1989 Plant Physiol. pmid:16666855
Ngam-Ek A et al. Malate-Induced Hysteresis of Phosphoenolpyruvate Carboxylase from Crassula argentea. 1989 Plant Physiol. pmid:16667161
Bouzayen M et al. Carrier-Mediated Uptake of 1-(Malonylamino)cyclopropane-1-Carboxylic Acid in Vacuoles Isolated from Catharanthus roseus Cells. 1989 Plant Physiol. pmid:16667182
pmid:16669637
pmid:16671812
pmid:16674057
Zhang Y et al. Phylophenetic properties of metabolic pathway topologies as revealed by global analysis. 2006 BMC Bioinformatics pmid:16684350
Kunz WS Application of the theory of steady-state flux control to mitochondrial beta-oxidation. 1991 Biomed. Biochim. Acta pmid:1668635
Cuthill DJ et al. Different patterns of axonal damage after intracerebral injection of malonate or AMPA. 2006 Exp. Neurol. pmid:16698016
Kulp DC and Jagalur M Causal inference of regulator-target pairs by gene mapping of expression phenotypes. 2006 BMC Genomics pmid:16719927
Batandier C et al. The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin. 2006 J. Bioenerg. Biomembr. pmid:16732470
pmid:16732471
Ruangpornvisuti V and Wanno B Molecular model for host–guest interaction of tetraamino-tert-butylthiacalix[4]arene and tetraamino-tert-butylcalix[4]arene receptors with carboxylate and dicarboxylate guests: an ONIOM study. 2007 J Mol Model pmid:16738872
Deegan C et al. In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)]x2H2O, [Cu(phen)2(mal)]x2H2O and [Mn(phen)2(mal)]x2H2O (malH2=malonic acid) using human cancer cells. 2007 Cancer Lett. pmid:16740357
Oh SJ et al. Construction of phylogenetic trees by kernel-based comparative analysis of metabolic networks. 2006 BMC Bioinformatics pmid:16753070
pmid:16755612
Saad LO et al. Lactate dehydrogenase activity is inhibited by methylmalonate in vitro. 2006 Neurochem. Res. pmid:16758363
pmid:16759857
pmid:16763307
Zhao B et al. Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2). 2006 Biochemistry pmid:16768445
Trask AV et al. Physical stability enhancement of theophylline via cocrystallization. 2006 Int J Pharm pmid:16769188
Tamaya K et al. Interpretation of solute retention of some monovalent inorganic anions in anion-exchange chromatography using a dicarboxylic Acid as an eluent. 2006 Anal Sci pmid:16770050
Fedotcheva NI et al. Nonezymatic formation of succinate in mitochondria under oxidative stress. 2006 Free Radic. Biol. Med. pmid:16781453
pmid:16786427
pmid:16787310
Kim HI et al. Cluster phase chemistry: gas-phase reactions of anionic sodium salts of dicarboxylic acid clusters with water molecules. 2006 J Phys Chem A pmid:16789762
pmid:16789765
Arthur CJ et al. The malonyl transferase activity of type II polyketide synthase acyl carrier proteins. 2006 Chem. Biol. pmid:16793516
pmid:16805497
Sivaramakrishnan S and Ramasarma T Oxidation of succinate in heart, brain, and kidney mitochondria in hypobaria and hypoxia. 1975 Environ Physiol Biochem pmid:168066
Holyoak T et al. Structural insights into the mechanism of PEPCK catalysis. 2006 Biochemistry pmid:16819824
Jackson CJ et al. The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes. 2006 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:16820687
pmid:16821924
pmid:16832499
pmid:16833327
pmid:16833384
pmid:16833452
Wang J et al. Coexistence of two bifurcation regimes in a closed ferroin-catalyzed Belousov-Zhabotinsky reaction. 2005 J Phys Chem A pmid:16833454
pmid:16833458
pmid:16833714
Kitahata H et al. Propagation of photosensitive chemical waves on the circular routes. 2005 J Phys Chem A pmid:16833846
pmid:16834142
pmid:16841363
Bulluss GH et al. trans-Platinum planar amine compounds with [N2O2] ligand donor sets: effects of carboxylate leaving groups and steric hindrance on chemical and biological properties. 2006 Inorg Chem pmid:16841974
pmid:16852134
pmid:16852158
pmid:16855730
de Spiegeleer B et al. Rapid determination of malonic acid by ion-pair reversed-phase high-performance liquid chromatography. 1986 J Pharm Biomed Anal pmid:16867607
pmid:16869601
pmid:16876761
pmid:16878946
Tsao R et al. Isoflavone profiles of red clovers and their distribution in different parts harvested at different growing stages. 2006 J. Agric. Food Chem. pmid:16881680
pmid:16903835
pmid:16904729
Wang X et al. Analysis of substrate-binding elements in OxlT, the oxalate:formate antiporter of Oxalobacter formigenes. 2006 Biochemistry pmid:16922510
Tang L et al. Inferring direct regulatory targets from expression and genome location analyses: a comparison of transcription factor deletion and overexpression. 2006 BMC Genomics pmid:16923194
Huang LS et al. Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state. 2006 Sep-Oct Biochim. Biophys. Acta pmid:16935256
Guo ML and Cao HX Poly[tetra-mu-aqua-hexaaquadi-mu3-malonato-dinitratodibarium(II)nickel(II)]. 2006 Acta Crystallogr C pmid:16954628
pmid:16999412
Manz N and Steinbock O Propagation failures, breathing pulses, and backfiring in an excitable reaction-diffusion system. 2006 Chaos pmid:17014246
Kripal R and Singh DK ESR and optical study of Cu2+ doped calcium malonate dihydrate. 2007 Spectrochim Acta A Mol Biomol Spectrosc pmid:17018262
pmid:17027119
Fondo M et al. Dinuclear Co(III)/Co(III) and Co(II)/Co(III) mixed-valent complexes: synthetic control of the cobalt oxidation level. 2006 Dalton Trans pmid:17047739
Zeevalk GD et al. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease. 2007 Exp. Neurol. pmid:17049515
Yennawar NH et al. Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis. 2006 J. Biol. Chem. pmid:17050531
Sasamoto N et al. Pd(II)-catalyzed asymmetric addition of malonates to dihydroisoquinolines. 2006 J. Am. Chem. Soc. pmid:17061867
Iversen C et al. The biochemical differentiation of Enterobacter sakazakii genotypes. 2006 BMC Microbiol. pmid:17067387
pmid:17068841
Wenzel SC et al. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. 2006 J. Am. Chem. Soc. pmid:17076505
Yun YS et al. Arg-158 is critical in both binding the substrate and stabilizing the transition-state oxyanion for the enzymatic reaction of malonamidase E2. 2006 J. Biol. Chem. pmid:17077089
pmid:17078611
Huang QY et al. Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. 2006 J. Neurosci. pmid:17079665
Ma Y et al. Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase. 2006 Chembiochem pmid:17086560
Romualdi C et al. Defining the gene expression signature of rhabdomyosarcoma by meta-analysis. 2006 BMC Genomics pmid:17090319
Moy LY et al. Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter. 2007 J. Pharmacol. Exp. Ther. pmid:17090704
Gao J et al. Determination of 1-naphthylamine by using oscillating chemical reaction. 2007 J. Hazard. Mater. pmid:17097225
Hegedüs L et al. Contribution to the chemistry of the Belousov-Zhabotinsky reaction. Products of the Ferriin-Bromomalonic acid and the Ferriin-Malonic acid reactions. 2006 J Phys Chem A pmid:17125298
pmid:17125465
pmid:17134758
Licht TR et al. Dietary carbohydrate source influences molecular fingerprints of the rat faecal microbiota. 2006 BMC Microbiol. pmid:17137493
pmid:17148896
Míguez DG et al. Experimental evidence of localized oscillations in the photosensitive chlorine dioxide-iodine-malonic acid reaction. 2006 Phys. Rev. Lett. pmid:17155511
pmid:17160178
Gomez-Lazaro M et al. Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. 2007 Mol. Pharmacol. pmid:17172466