| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperglycemia | D006943 | 21 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Mitochondrial Diseases | D028361 | 25 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nam KH et al. | Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure. | 2009 | Proteins | pmid:18831047 |
| Maertens B et al. | Gene optimization mechanisms: a multi-gene study reveals a high success rate of full-length human proteins expressed in Escherichia coli. | 2010 | Protein Sci. | pmid:20506237 |
| McPherson A | A comparison of salts for the crystallization of macromolecules. | 2001 | Protein Sci. | pmid:11266627 |
| Jung JW et al. | The active site and substrates binding mode of malonyl-CoA synthetase determined by transferred nuclear Overhauser effect spectroscopy, site-directed mutagenesis, and comparative modeling studies. | 2000 | Protein Sci. | pmid:10933494 |
| Scheer JM et al. | Malonate-assisted purification of human caspases. | 2005 | Protein Expr. Purif. | pmid:15802232 |
| Li J et al. | Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. | 2013 | Protein Cell | pmid:23807634 |
| LIFSON N and STOLEN JA | Metabolism of C13-carboxyl-labeled malonate by the intact mouse. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:15440851 |
| Risquez A et al. | Effects of malonate administration on renal ammoniagenesis in intact dogs. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2602392 |
| POTTER VR and SIMONSON H | Sequential blocking of metabolic pathways in vivo. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816386 |
| Wada H et al. | Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9037098 |
| Calkins MJ et al. | Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15611470 |
| Pain F et al. | In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12136134 |
| Kagawa Y | ATP synthase: from single molecule to human bioenergetics. | 2010 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:20689227 |
| Dongmei H et al. | Synthesis and analgesic activity of N,N'-dicarbonyltryptamines. | 2000 | Prep. Biochem. Biotechnol. | pmid:10919562 |
| Cawthon D et al. | Investigation of proton conductance in liver mitochondria of broilers with pulmonary hypertension syndrome. | 2004 | Poult. Sci. | pmid:14979578 |
| ZÃková A et al. | The F(0)F(1)-ATP synthase complex contains novel subunits and is essential for procyclic Trypanosoma brucei. | 2009 | PLoS Pathog. | pmid:19436713 |
| Dolezal P et al. | The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica. | 2010 | PLoS Pathog. | pmid:20333239 |
| Kozjak-Pavlovic V et al. | Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. | 2009 | PLoS Pathog. | pmid:19851451 |
| Karakikes I et al. | Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. | 2009 | PLoS ONE | pmid:19649297 |
| Brown AK et al. | Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases. | 2009 | PLoS ONE | pmid:19609444 |
| Pistollato F et al. | Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells. | 2009 | PLoS ONE | pmid:19587783 |
| Tiziani S et al. | Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines. | 2009 | PLoS ONE | pmid:19158949 |
| Seifert EL et al. | Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria. | 2010 | PLoS ONE | pmid:20352092 |
| Finley LW et al. | Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. | 2011 | PLoS ONE | pmid:21858060 |
| Jeong YS et al. | Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. | 2011 | PLoS ONE | pmid:21811631 |
| Rogers GW et al. | High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. | 2011 | PLoS ONE | pmid:21799747 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Egea PF et al. | Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. | 2008 | PLoS ONE | pmid:18953414 |
| Lin H et al. | The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. | 2011 | PLoS ONE | pmid:21552483 |
| GarcÃa-Torres I et al. | Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes. | 2011 | PLoS ONE | pmid:21533154 |
| Rudrappa T et al. | Cyanogenic pseudomonads influence multitrophic interactions in the rhizosphere. | 2008 | PLoS ONE | pmid:18446201 |
| Thomas B et al. | Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. | 2011 | PLoS ONE | pmid:21304957 |
| Qi M et al. | Genome sequence analyses of Pseudomonas savastanoi pv. glycinea and subtractive hybridization-based comparative genomics with nine pseudomonads. | 2011 | PLoS ONE | pmid:21304594 |
| Kubicek J et al. | Controlled in meso phase crystallization--a method for the structural investigation of membrane proteins. | 2012 | PLoS ONE | pmid:22536388 |
| Kil DY et al. | Age and diet affect gene expression profiles in canine liver tissue. | 2010 | PLoS ONE | pmid:20967283 |
| Shi T et al. | cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. | 2010 | PLoS ONE | pmid:20957031 |
| Wise JK et al. | Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration. | 2010 | PLoS ONE | pmid:20957030 |
| Pradhan RK et al. | Characterization of membrane potential dependency of mitochondrial Ca2+ uptake by an improved biophysical model of mitochondrial Ca2+ uniporter. | 2010 | PLoS ONE | pmid:20949039 |
| Granjon T et al. | Structure-function relations in oxaloacetate decarboxylase complex. Fluorescence and infrared approaches to monitor oxomalonate and Na(+) binding effect. | 2010 | PLoS ONE | pmid:20543879 |
| Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
| Gonzalvez F et al. | Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin. | 2010 | PLoS ONE | pmid:20179769 |
| Zhao JS et al. | Shewanella spp. genomic evolution for a cold marine lifestyle and in-situ explosive biodegradation. | 2010 | PLoS ONE | pmid:20174598 |
| Smejkalová H et al. | Methanol assimilation in Methylobacterium extorquens AM1: demonstration of all enzymes and their regulation. | 2010 | PLoS ONE | pmid:20957036 |
| Hagemann TL et al. | Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival. | 2012 | PLoS ONE | pmid:22693571 |
| Scalliet G et al. | Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. | 2012 | PLoS ONE | pmid:22536383 |
| Xu XM et al. | Dual localized AtHscB involved in iron sulfur protein biogenesis in Arabidopsis. | 2009 | PLoS ONE | pmid:19865480 |
| Gueguen C et al. | Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition. | 2014 | PLoS ONE | pmid:24586272 |
| Zuno-Floriano FG et al. | Effect of Acinetobacter sp on metalaxyl degradation and metabolite profile of potato seedlings (Solanum tuberosum L.) alpha variety. | 2012 | PLoS ONE | pmid:22363586 |
| Fujii T and Albarède F | Ab initio calculation of the Zn isotope effect in phosphates, citrates, and malates and applications to plants and soil. | 2012 | PLoS ONE | pmid:22363478 |
| Wang N et al. | Changes in soybean global gene expression after application of lipo-chitooligosaccharide from Bradyrhizobium japonicum under sub-optimal temperature. | 2012 | PLoS ONE | pmid:22348109 |