| MeSH term | MeSH ID | Detail |
|---|---|---|
| Parkinson Disease | D010300 | 53 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lebel H and Leogane O | Boc-protected amines via a mild and efficient one-pot Curtius rearrangement. | 2005 | Org. Lett. | pmid:16146363 |
| Ashfeld BL and Martin SF | Enantioselective syntheses of tremulenediol A and tremulenolide A. | 2005 | Org. Lett. | pmid:16178577 |
| Lee GY et al. | Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. | 2005 | Thromb. Res. | pmid:15668191 |
| McCooey SH and Connon SJ | Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:16136619 |
| Kim SC et al. | Sensitive HPLC method for quantitation of paclitaxel (Genexol in biological samples with application to preclinical pharmacokinetics and biodistribution. | 2005 | J Pharm Biomed Anal | pmid:16085137 |
| D'Alessandro TL et al. | Metabolism of phytoestrogen conjugates. | 2005 | Meth. Enzymol. | pmid:16399358 |
| Gunnlaugsson T et al. | Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate. | 2005 | Org. Biomol. Chem. | pmid:15602598 |
| Calkins MJ et al. | Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15611470 |
| Fernandez-Gomez FJ et al. | Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. | 2005 | Neuroscience | pmid:15964487 |
| Innocenti A et al. | Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15664815 |
| Scheer JM et al. | Malonate-assisted purification of human caspases. | 2005 | Protein Expr. Purif. | pmid:15802232 |
| Ishikura S et al. | Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. | 2005 | J. Biochem. | pmid:15809331 |
| Kaya K et al. | Selective control of toxic Microcystis water blooms using lysine and malonic acid: an enclosure experiment. | 2005 | Environ. Toxicol. | pmid:15793822 |
| Xiao R et al. | Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. | 2005 | Mol. Cancer | pmid:15644144 |
| Fatland BL et al. | Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis. | 2005 | Plant Cell | pmid:15608338 |
| Brandner K et al. | The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. | 2005 | J. Biol. Chem. | pmid:15591051 |
| Darvesh AS and Gudelsky GA | Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT. | 2005 | Brain Res. | pmid:16098955 |
| Rahman AS et al. | Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series. | 2005 | J. Biol. Chem. | pmid:15583005 |
| Baby SM et al. | Role of mitochondria in the regulation of hypoxia-inducible factor-1alpha in the rat carotid body glomus cells. | 2005 | Histochem. Cell Biol. | pmid:16034640 |
| Fernandez-Gomez FJ et al. | Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway. | 2005 | Br. J. Pharmacol. | pmid:15655518 |
| Burckhardt BC et al. | Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. | 2005 | Am. J. Physiol. Renal Physiol. | pmid:15561973 |
| Paucard A et al. | Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone. | 2005 | Fundam Clin Pharmacol | pmid:15660960 |
| Lin Y et al. | The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. | 2005 | J. Biol. Chem. | pmid:15536073 |
| Goñi-Allo B et al. | In vivo studies on the protective role of minocycline against excitotoxicity caused by malonate or N-methyl-d-aspartate. | 2005 | Exp. Neurol. | pmid:15649488 |
| Sebban M et al. | Tautomerism and 1H, 13C and 15N NMR spectral assignments of some nitro derivatives of malonic acid diamide. | 2005 | Magn Reson Chem | pmid:15864818 |
| Diao ZY et al. | [Establishment of the organotypic model of amyotrophic lateral sclerosis from the SD rats' spinal cord]. | 2005 | Beijing Da Xue Xue Bao | pmid:15841139 |
| Lorenzo M et al. | Inhibition of laccase activity from Trametes versicolor by heavy metals and organic compounds. | 2005 | Chemosphere | pmid:15993161 |
| Nguyen TH et al. | Conformations, energies, and intramolecular hydrogen bonds in dicarboxylic acids: implications for the design of synthetic dicarboxylic acid receptors. | 2005 | J Comput Chem | pmid:15962275 |
| Lorenc-Koci E et al. | 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity. | 2005 | Brain Res. | pmid:16004976 |
| Wycherley G et al. | Oxidative phosphorylation and the tricarboxylic acid cycle are essential for normal development of mouse ovarian follicles. | 2005 | Hum. Reprod. | pmid:16006477 |
| Kachlicki P et al. | Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. | 2005 | J Mass Spectrom | pmid:15971291 |
| Biaglow J et al. | Factors controlling oxygen utilization. | 2005 | Adv. Exp. Med. Biol. | pmid:16594168 |
| Wang J et al. | Coexistence of two bifurcation regimes in a closed ferroin-catalyzed Belousov-Zhabotinsky reaction. | 2005 | J Phys Chem A | pmid:16833454 |
| Kitahata H et al. | Propagation of photosensitive chemical waves on the circular routes. | 2005 | J Phys Chem A | pmid:16833846 |
| Haas R et al. | Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14564485 |
| Wu Q et al. | LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans. | 2004 | J. Agric. Food Chem. | pmid:15137811 |
| Hopwood DA | Cracking the polyketide code. | 2004 | PLoS Biol. | pmid:14966534 |
| Stieglitz K et al. | Monitoring the transition from the T to the R state in E.coli aspartate transcarbamoylase by X-ray crystallography: crystal structures of the E50A mutant enzyme in four distinct allosteric states. | 2004 | J. Mol. Biol. | pmid:15288791 |
| Romanowski MJ et al. | Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. | 2004 | Structure | pmid:15296730 |
| Nelson J et al. | Steric complementarity in carboxylate anion recognition. | 2004 | Dalton Trans | pmid:15356717 |
| Maciel EN et al. | Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition. | 2004 | J. Neurochem. | pmid:15312158 |
| Gołembiowska K and Dziubina A | Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. | 2004 | Neuropharmacology | pmid:15275831 |
| Kanki R et al. | Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. | 2004 | Brain Res. | pmid:15223368 |
| Fleck J et al. | Intrastriatal malonate administration induces convulsive behaviour in rats. | 2004 | J. Inherit. Metab. Dis. | pmid:15159652 |
| Ekaratanawong S et al. | Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. | 2004 | J. Pharmacol. Sci. | pmid:15037815 |
| Maragos WF et al. | Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. | 2004 | Neurochem. Res. | pmid:15098936 |
| Fleming I and Ramarao C | Decarboxylative elimination of enol triflates as a general synthesis of acetylenes. | 2004 | Org. Biomol. Chem. | pmid:15136807 |
| Baud S et al. | gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase. | 2004 | EMBO Rep. | pmid:15088065 |
| Shiva S et al. | Mechanisms of the interaction of nitroxyl with mitochondria. | 2004 | Biochem. J. | pmid:14723605 |
| Paucard A et al. | Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatum. | 2004 | Eur. J. Pharmacol. | pmid:14729115 |
| Maklashina E et al. | Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart. | 2004 | FEBS Lett. | pmid:14706827 |
| Nam NH et al. | Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. | 2004 | Bioorg. Med. Chem. | pmid:14759738 |
| Huber R et al. | Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices. | 2004 | J. Neurosci. Res. | pmid:14743458 |
| Zalups RK and Ahmad S | Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. | 2004 | J. Am. Soc. Nephrol. | pmid:15284288 |
| Wang H and Shooter D | Low molecular weight dicarboxylic acids in PM10 in a city with intensive solid fuel burning. | 2004 | Chemosphere | pmid:15251287 |
| Zalups RK et al. | Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. | 2004 | Kidney Int. | pmid:15200431 |
| Zhang YQ and Keller NP | Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans. | 2004 | Mol. Microbiol. | pmid:15066039 |
| Chen H and Harrison PH | Investigation of the origin of C2 units in biosynthesis of streptolydigin. | 2004 | Org. Lett. | pmid:15496092 |
| Cawthon D et al. | Investigation of proton conductance in liver mitochondria of broilers with pulmonary hypertension syndrome. | 2004 | Poult. Sci. | pmid:14979578 |
| Scholte AA et al. | Synthesis and biological activity of isopentenyl diphosphate analogues. | 2004 | Bioorg. Med. Chem. | pmid:14759736 |
| Ohtsuki S et al. | Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14762099 |
| Dickschat JS et al. | Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. | 2004 | Chembiochem | pmid:15174160 |
| Chovancek M et al. | Development of a fully buffered molybdate electrolyte for capillary electrophoresis with indirect detection and its use for analysis of anions in Bayer liquor. | 2004 | Electrophoresis | pmid:14760635 |
| Kiss C et al. | Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. | 2004 | Brain Res. | pmid:14988042 |
| Comer E et al. | Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. | 2004 | J. Am. Chem. Soc. | pmid:15584744 |
| Solano-Serena F et al. | Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. | 2004 | J. Appl. Microbiol. | pmid:15281945 |
| Le Visage C et al. | Efficacy of paclitaxel released from bio-adhesive polymer microspheres on model superficial bladder cancer. | 2004 | J. Urol. | pmid:14767342 |
| Morland C et al. | Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. | 2004 | J. Cereb. Blood Flow Metab. | pmid:15545916 |
| Cornet S et al. | Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline. | 2004 | Eur. J. Pharmacol. | pmid:15556143 |
| Klivenyi P et al. | Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. | 2004 | J. Neurochem. | pmid:15009635 |
| Murphy RC and Messer A | A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease. | 2004 | Brain Res. Mol. Brain Res. | pmid:14969746 |
| Kucera LS et al. | Synthesis and evaluation of a novel synthetic phosphocholine lipid-AZT conjugate that double-targets wild-type and drug resistant variants of HIV. | 2004 | Nucleosides Nucleotides Nucleic Acids | pmid:15043162 |
| Asanuma T et al. | Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method. | 2004 | Neurosci. Lett. | pmid:15050711 |
| De Stefano C et al. | Binding of fluoride and carbonate by open chain polyammonium cations. | 2004 | Talanta | pmid:18969633 |
| Liu SY et al. | Calix[4]arenes containing thiourea and amide moieties: neutral receptors towards alpha,omega-dicarboxylate anions. | 2004 | Org. Biomol. Chem. | pmid:15162208 |
| Puchowicz MA et al. | Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria--case studies. | 2004 | Mitochondrion | pmid:16120399 |
| Towler CS et al. | Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'. | 2004 | J. Am. Chem. Soc. | pmid:15479091 |
| Yang L et al. | A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. | 2004 | Neurobiol. Dis. | pmid:15474362 |
| Magwene PM and Kim J | Estimating genomic coexpression networks using first-order conditional independence. | 2004 | Genome Biol. | pmid:15575966 |
| Thatcher GR et al. | Novel nitrates as NO mimetics directed at Alzheimer's disease. | 2004 | J. Alzheimers Dis. | pmid:15665418 |
| Yurgel SN and Kahn ML | Dicarboxylate transport by rhizobia. | 2004 | FEMS Microbiol. Rev. | pmid:15374663 |
| Bufetov EN et al. | [Effect of malonate on the structural and functional changes of wheat Triticum aestivum L. root cells]. | 2004 | Tsitologiia | pmid:15704878 |
| Ohshima T | Enantioselective total syntheses of several bioactive natural products based on the development of practical asymmetric catalysis. | 2004 | Chem. Pharm. Bull. | pmid:15340187 |
| Chou HC et al. | Multiple hydrogen bonds tuning guest/host excited-state proton transfer reaction: its application in molecular recognition. | 2004 | J. Am. Chem. Soc. | pmid:14871093 |
| Burckhardt BC et al. | Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3. | 2004 | Cell. Physiol. Biochem. | pmid:15319545 |
| Stock I et al. | Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. | 2004 | Clin. Microbiol. Infect. | pmid:15301675 |
| Jeong J et al. | A nodule-specific dicarboxylate transporter from alder is a member of the peptide transporter family. | 2004 | Plant Physiol. | pmid:15001700 |
| Toulmond S et al. | Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease. | 2004 | Br. J. Pharmacol. | pmid:14744804 |
| Kato F and Hiroi K | Stereochemistry of the asymmetric carbopalladation of allenes followed by nucleophilic substitution reactions with carbo- and aminonucleophiles. | 2004 | Chem. Pharm. Bull. | pmid:14709874 |
| Miyata N et al. | Enzymatic formation of manganese oxides by an Acremonium-like hyphomycete fungus, strain KR21-2. | 2004 | FEMS Microbiol. Ecol. | pmid:19712351 |
| Ma HW et al. | Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. | 2004 | BMC Bioinformatics | pmid:15603590 |
| Taniguchi Y et al. | Differentiation of dicarboxylate transporters in mesophyll and bundle sheath chloroplasts of maize. | 2004 | Plant Cell Physiol. | pmid:14988489 |
| de Rijke E et al. | Liquid chromatography coupled to nuclear magnetic resonance spectroscopy for the identification of isoflavone glucoside malonates in T. pratense L. leaves. | 2004 | J Sep Sci | pmid:15495407 |
| Furin A et al. | Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates. | 2003 Jul-Aug | Eur J Med Chem | pmid:12932905 |
| Botta M et al. | Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution: an NMR relaxometric study. | 2003 | Chemistry | pmid:12740859 |
| Organ MG et al. | On the regiochemistry of nucleophilic attack on 2-halo pi-allyl complexes. 4. The effect of silver acetate and nucleophile concentrations in competitive nucleophilic attack with malonate and phenoxide nucleophiles. | 2003 | J. Org. Chem. | pmid:12737572 |
| Brinkmann T et al. | Photoformation of low-molecular-weight organic acids from brown water dissolved organic matter. | 2003 | Environ. Sci. Technol. | pmid:14524452 |
| Sun F and Darbre T | The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase. | 2003 | Org. Biomol. Chem. | pmid:14527146 |
| Pan D et al. | PathMAPA: a tool for displaying gene expression and performing statistical tests on metabolic pathways at multiple levels for Arabidopsis. | 2003 | BMC Bioinformatics | pmid:14604444 |
| Newell DR et al. | Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. | 2003 | Br. J. Cancer | pmid:12888809 |