| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Beal MF et al. | Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. | 1993 | J. Neurochem. | pmid:7689641 |
| Klein BY et al. | Selection of malonate-resistant stromal cell-derived osteoprogenitor cells in vitro. | 1993 | J. Cell. Biochem. | pmid:7680046 |
| Davolio C and Greenamyre JT | Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. | 1995 | Neurosci. Lett. | pmid:7675303 |
| O'Donnell M et al. | Evidence from affinity precipitation that glutamate analogues are bound in a folded conformation to glutamate dehydrogenase. | 1995 | Biochem. Soc. Trans. | pmid:7672393 |
| Raginskaia VP | [Nomenclature of the S. coli (E. coli) No. 2624/36 and 5396/38 strains]. | 1975 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:766529 |
| Armson A et al. | The effect of electron transport (ET) inhibitors and thiabendazole on the fumarate reductase (FR) and succinate dehydrogenase (SDH) of Strongyloides ratti infective (L3) larvae. | 1995 | Int. J. Parasitol. | pmid:7622334 |
| Matalon R et al. | Malonic aciduria and cardiomyopathy. | 1993 | J. Inherit. Metab. Dis. | pmid:7609455 |
| Schulz JB et al. | Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. | 1995 | J. Cereb. Blood Flow Metab. | pmid:7593355 |
| Sánchez-Alcázar JA et al. | Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. | 1995 | J. Biol. Chem. | pmid:7592589 |
| Messam CA et al. | Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. | 1995 | Brain Res. | pmid:7583227 |
| Cheng Y et al. | pH dependence of specific divalent anion binding to the N-lobe of recombinant human transferrin. | 1995 | Biochemistry | pmid:7578099 |
| Bazzett TJ et al. | Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum. | 1995 | Exp. Neurol. | pmid:7556544 |
| Maragos WF and Silverstein FS | Inhibition of nitric oxide synthase activity attenuates striatal malonate lesions in rats. | 1995 | J. Neurochem. | pmid:7536812 |
| Greene JG and Greenamyre JT | Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. | 1995 | J. Neurochem. | pmid:7536810 |
| Schmehl I et al. | Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. | 1995 | FEBS Lett. | pmid:7498500 |
| Maragos WF and Silverstein FS | The mitochondrial inhibitor malonate enhances NMDA toxicity in the neonatal rat striatum. | 1995 | Brain Res. Dev. Brain Res. | pmid:7493402 |
| Jocelyn PC | The reduction of diamide by rat liver mitochondria and the role of glutathione. | 1978 | Biochem. J. | pmid:747642 |
| Ye B et al. | L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. | 1995 | J. Med. Chem. | pmid:7473554 |
| Parvin R et al. | Inhibition of mitochondrial carnitine-acylcarnitine translocase by sulfobetaines. | 1980 | Can. J. Biochem. | pmid:7459685 |
| Masterson E and Chader GJ | Pigment epithelial cells in culture. Metabolic pathways required for phagocytosis. | 1981 | Invest. Ophthalmol. Vis. Sci. | pmid:7451071 |