Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

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What functions are associated with Malonic acid?


Related references are published most in these journals:

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What lipids are associated with Malonic acid?

Related references are published most in these journals:

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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Jang YJ et al. Tandem three-component reactions of aldehyde, alkyl acrylate, and dialkylmalonate catalyzed by ethyl diphenylphosphine. 2012 Molecules pmid:22446986
Führs H et al. Functional associations between the metabolome and manganese tolerance in Vigna unguiculata. 2012 J. Exp. Bot. pmid:21934118
Syu SE et al. Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates. 2012 Chirality pmid:22589149
Orellana A et al. A Diels-Alder-based total synthesis of (-)-kainic acid. 2012 J. Org. Chem. pmid:22551444
Limwikrant W et al. Formation mechanism of a new carbamazepine/malonic acid cocrystal polymorph. 2012 Int J Pharm pmid:22537807
Desvergnes S et al. Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase. 2012 Bioorg. Med. Chem. pmid:22269276
Ghosh Dastidar T and Netravali AN 'Green' crosslinking of native starches with malonic acid and their properties. 2012 Carbohydr Polym pmid:22944425
Yang J et al. One-step hydrothermal synthesis of carboxyl-functionalized upconversion phosphors for bioapplications. 2012 Chemistry pmid:22996059
Ghosh SK et al. Highly enantioselective and recyclable organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in aqueous media. 2012 Org. Biomol. Chem. pmid:22976596
Bonhomme C et al. 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. 2012 J. Am. Chem. Soc. pmid:22738329
Bauwens M et al. Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers. 2012 PLoS ONE pmid:22719886
Callahan DL et al. Elemental and metabolite profiling of nickel hyperaccumulators from New Caledonia. 2012 Phytochemistry pmid:22795763
Shevchenko A et al. A new cocrystal and salts of itraconazole: comparison of solid-state properties, stability and dissolution behavior. 2012 Int J Pharm pmid:22750429
Liu Q et al. Structural effect and mechanism of C70-carboxyfullerenes as efficient sensitizers against cancer cells. 2012 Small pmid:22508680
Mitra T et al. Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions. 2012 J Mater Sci Mater Med pmid:22367159
Du X et al. [Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors]. 2012 Yao Xue Xue Bao pmid:22645761
Park SY et al. An analysis of the concentration change of intermediate metabolites by gene manipulation in fatty acid biosynthesis. 2012 Enzyme Microb. Technol. pmid:22664193
Chojkier M et al. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. 2012 PLoS ONE pmid:22412837
Batur M et al. Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. 2012 J Tradit Chin Med pmid:22594115
Li WS et al. Regulation of Turing patterns in a spatially extended chlorine-iodine-malonic-acid system with a local concentration-dependent diffusivity. 2012 Phys Rev E Stat Nonlin Soft Matter Phys pmid:23005187
Xue J et al. Novel compound heterozygous mutation of MLYCD in a Chinese patient with malonic aciduria. 2012 Mol. Genet. Metab. pmid:22104738
Maune MW and Tanner RS Description of Anaerobaculum hydrogeniformans sp. nov., an anaerobe that produces hydrogen from glucose, and emended description of the genus Anaerobaculum. 2012 Int. J. Syst. Evol. Microbiol. pmid:21602364
Chanumolu SK et al. UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. 2012 PLoS ONE pmid:22431985
Finnegan PM and Chen W Arsenic toxicity: the effects on plant metabolism. 2012 Front Physiol pmid:22685440
Chen JW et al. Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress. 2012 PLoS ONE pmid:22675497
Khodadad CL and Foster JS Metagenomic and metabolic profiling of nonlithifying and lithifying stromatolitic mats of Highborne Cay, The Bahamas. 2012 PLoS ONE pmid:22662280
Michalski R et al. Application of hyphenated techniques in speciation analysis of arsenic, antimony, and thallium. 2012 ScientificWorldJournal pmid:22654649
Ariza AC et al. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. 2012 Front Endocrinol (Lausanne) pmid:22649411
Pittman JK Multiple Transport Pathways for Mediating Intracellular pH Homeostasis: The Contribution of H(+)/ion Exchangers. 2012 Front Plant Sci pmid:22645567
Haferkamp I and Schmitz-Esser S The plant mitochondrial carrier family: functional and evolutionary aspects. 2012 Front Plant Sci pmid:22639632
Tomita Y et al. Genome and transcriptome analysis of the food-yeast Candida utilis. 2012 PLoS ONE pmid:22629373
Thein M et al. DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. 2012 PLoS ONE pmid:22590556
Lapanje K et al. Bis(acetato-κO)bis-[2-(pyridin-2-yl)ethanol-κ(2)N,O]copper(II). 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22590106
Benkanoun A et al. Intra- and supra-molecular inter-actions in cis,mer-diaqua-tris-(1H-imidazole-κN(3))(terephthalato-κO)cobalt(II) monohydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22589841
Liew CW et al. Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis. 2012 J. Biol. Chem. pmid:22589546
Anand K et al. Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. 2012 PLoS ONE pmid:22574179
Moldes D et al. Role of laccase and low molecular weight metabolites from Trametes versicolor in dye decolorization. 2012 ScientificWorldJournal pmid:22566767
Tao X et al. Digital gene expression analysis based on integrated de novo transcriptome assembly of sweet potato [Ipomoea batatas (L.) Lam]. 2012 PLoS ONE pmid:22558397
Li C et al. Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm. 2012 J. Biol. Chem. pmid:22493500
Bouhlel A et al. New methodology for the synthesis of thiobarbiturates mediated by manganese(III) acetate. 2012 Molecules pmid:22491680
Russo Krauss I et al. Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data. 2012 Int J Mol Sci pmid:22489183
Shi L et al. Chlorine dioxide-iodide-methyl acetoacetate oscillation reaction investigated by UV-vis and online FTIR spectrophotometric method. 2012 ScientificWorldJournal pmid:22454614
Wong YH et al. Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. 2012 PLoS ONE pmid:22448242
Zhang H and Li M Transcriptional profiling of ESTs from the biocontrol fungus Chaetomium cupreum. 2012 ScientificWorldJournal pmid:22448129
Jin YW and Zhu HL Poly[[penta-aqua-(μ(4)-pyridine-2,4,6-tri-carboxyl-ato)(μ(3)-pyridine-2,4,6-tri-carboxyl-ato)disamarium(III)] mono-hydrate]. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22412433
Zhang XJ and Guo ML catena-Poly[[bis-(1-methyl-1H-imidazole-κN)zinc]-μ-3-nitro-phthalato-κO:O]. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22412416
Ashrafian H et al. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. 2012 Cell Metab. pmid:22405071
Trushina E et al. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. 2012 PLoS ONE pmid:22393443
Tran QM et al. Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase. 2012 PLoS ONE pmid:22393428
Totir M et al. Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. 2012 PLoS ONE pmid:22393408
Merewitz EB et al. Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation. 2012 J. Exp. Bot. pmid:22131157
Vujčić M et al. A comparative study of DNA binding and cell cycle phase perturbation by the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide N',N'(2) -bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. 2011 May-Jun J. Biochem. Mol. Toxicol. pmid:21671309
Zeng WL 2,2-Dimethyl-5-(2,3,4-trimeth-oxy-benzyl-idene)-1,3-dioxane-4,6-dione. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22090981
Rong T 2,4,6-Trimethyl-anilinium 2-carb-oxy-ethano-ate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22090968
Zeng WL 5,5'-[(2,4-Dichloro-phen-yl)methyl-ene]bis-(2,2-dimethyl-1,3-dioxane-4,6-dione). 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22090945
Feng LP and Zhao L 2-Amino-anilinium 2-carb-oxy-acetate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22090933
Roth S Mathematics and biology: a Kantian view on the history of pattern formation theory. 2011 Dev. Genes Evol. pmid:22086125
Holley AK et al. Manganese superoxide dismutase: guardian of the powerhouse. 2011 Int J Mol Sci pmid:22072939
Chen H et al. Malonyl-CoA synthetase, encoded by ACYL ACTIVATING ENZYME13, is essential for growth and development of Arabidopsis. 2011 Plant Cell pmid:21642549
Kotova EA et al. Selective permeabilization of lipid membranes by photodynamic action via formation of hydrophobic defects or pre-pores. 2011 Biochim. Biophys. Acta pmid:21663731
Funakoshi T et al. Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine. 2011 Toxicol In Vitro pmid:21664962
Jose DA et al. Allosteric P═O-based receptors for dicarboxylic acids. 2011 Org. Lett. pmid:21667961
Hanif M et al. From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands. 2011 J. Inorg. Biochem. pmid:21194622
Wolfenden R et al. Kinetic challenges facing oxalate, malonate, acetoacetate, and oxaloacetate decarboxylases. 2011 J. Am. Chem. Soc. pmid:21434608
Sivananthan SN and Leavitt BR Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice. 2011 Neurobiol. Aging pmid:21741126
Ghorai S et al. Spectroscopic evidence of keto-enol tautomerism in deliquesced malonic acid particles. 2011 J Phys Chem A pmid:21480651
Barderas MG et al. Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases. 2011 J. Biomed. Biotechnol. pmid:21274272
Davies DR et al. An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. 2011 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:21904048
Virmani A et al. Acetyl-L-Carnitine Modulates TP53 and IL10 Gene Expression Induced by 3-NPA Evoked Toxicity in PC12 Cells. 2011 Curr Neuropharmacol pmid:21886589
Finley LW et al. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. 2011 PLoS ONE pmid:21858060
Lau SK et al. Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis. 2011 Cell Biosci pmid:21849034
Sun D et al. Diethyl 2-{4-diethyl-amino-2-[(dimethyl-carbamothio-yl)-oxy]benzyl-idene}malonate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21837219
Ranjith S et al. Diethyl 2-{[3-(2-meth-oxy-benz-yl)thio-phen-2-yl]methyl-idene}malonate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21837085
Zhou H et al. Poly[[aqua-tris-(μ-benzene-1,4-dicarboxyl-ato)tricobalt(II)] methanol monosolvate monohydrate]. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21836846
Jeong YS et al. Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. 2011 PLoS ONE pmid:21811631
Bian W et al. The intermediate products in the degradation of 4-chlorophenol by pulsed high voltage discharge in water. 2011 J. Hazard. Mater. pmid:21802204
Wang YY and Tsay YF Arabidopsis nitrate transporter NRT1.9 is important in phloem nitrate transport. 2011 Plant Cell pmid:21571952
Fang X et al. Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons. 2011 Proteome Sci pmid:21569547
Milan M et al. Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring. 2011 BMC Genomics pmid:21569398
Kim SH et al. Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with H-NMR based metabolic profiling. 2011 J Clin Biochem Nutr pmid:21562641
Lin H et al. The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. 2011 PLoS ONE pmid:21552483
Ghasemzadeh A and Jaafar HZ Effect of CO(2) enrichment on synthesis of some primary and secondary metabolites in ginger (Zingiber officinale Roscoe). 2011 Int J Mol Sci pmid:21541046
García-Torres I et al. Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes. 2011 PLoS ONE pmid:21533154
Kalaitzis JA et al. Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. 2011 Bioorg. Med. Chem. pmid:21531566
Lackner G et al. Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. 2011 BMC Genomics pmid:21539752
Hughes AJ and Keatinge-Clay A Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB. 2011 Chem. Biol. pmid:21338915
Thomas B et al. Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. 2011 PLoS ONE pmid:21304957
Qi M et al. Genome sequence analyses of Pseudomonas savastanoi pv. glycinea and subtractive hybridization-based comparative genomics with nine pseudomonads. 2011 PLoS ONE pmid:21304594
Kim J and Winfree E Synthetic in vitro transcriptional oscillators. 2011 Mol. Syst. Biol. pmid:21283141
Sloan JL et al. Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. 2011 Nat. Genet. pmid:21841779
Wölk C et al. Synthesis and DNA transfection properties of new head group modified malonic acid diamides. 2011 Int J Pharm pmid:21354464
Jeon E et al. Development of Escherichia coli MG1655 strains to produce long chain fatty acids by engineering fatty acid synthesis (FAS) metabolism. 2011 Enzyme Microb. Technol. pmid:22112270
Whitaker-Menezes D et al. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. 2011 Cell Cycle pmid:22134189
Alfares A et al. Combined malonic and methylmalonic aciduria: exome sequencing reveals mutations in the ACSF3 gene in patients with a non-classic phenotype. 2011 J. Med. Genet. pmid:21785126
Witkowski A et al. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. 2011 J. Biol. Chem. pmid:21846720
Tyson T et al. Functional and highly porous scaffolds for biomedical applications. 2011 Macromol Biosci pmid:21842506
Menes RJ et al. Halomonas vilamensis sp. nov., isolated from high-altitude Andean lakes. 2011 Int. J. Syst. Evol. Microbiol. pmid:20584819
Araújo WL et al. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. 2011 Plant Cell pmid:21307286
Kaufhold M et al. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3. 2011 Am. J. Physiol. Renal Physiol. pmid:21865262
Malik G et al. Aziridines from intramolecular alkene aziridination of sulfamates: reactivity toward carbon nucleophiles. application to the synthesis of spisulosine and its fluoro analogue. 2011 J. Org. Chem. pmid:21812488