Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Nerve Degeneration D009410 53 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Insulin Resistance D007333 99 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Ashfeld BL and Martin SF Enantioselective syntheses of tremulenediol A and tremulenolide A. 2005 Org. Lett. pmid:16178577
Lee GY et al. Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. 2005 Thromb. Res. pmid:15668191
McCooey SH and Connon SJ Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance. 2005 Angew. Chem. Int. Ed. Engl. pmid:16136619
López-Muñoz F et al. The history of barbiturates a century after their clinical introduction. 2005 Neuropsychiatr Dis Treat pmid:18568113
Hulcoop DG and Burton JW Synthesis of fused tricyclic gamma-lactones mediated by manganese(III) acetate. 2005 Chem. Commun. (Camb.) pmid:16175293
Calkins MJ et al. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15611470
Mizuarai S et al. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. 2005 J. Biol. Chem. pmid:16027120
Fernandez-Gomez FJ et al. Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. 2005 Neuroscience pmid:15964487
Kapich AN et al. Involvement of lipid peroxidation in the degradation of a non-phenolic lignin model compound by manganese peroxidase of the litter-decomposing fungus Stropharia coronilla. 2005 Biochem. Biophys. Res. Commun. pmid:15796893
Innocenti A et al. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. 2005 Bioorg. Med. Chem. Lett. pmid:15664815
Ishikura S et al. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. 2005 J. Biochem. pmid:15809331
Kaya K et al. Selective control of toxic Microcystis water blooms using lysine and malonic acid: an enclosure experiment. 2005 Environ. Toxicol. pmid:15793822
Azurmendi HF et al. Half-of-the-sites binding of reactive intermediates and their analogues to 4-oxalocrotonate tautomerase and induced structural asymmetry of the enzyme. 2005 Biochemistry pmid:15909987
Chang W et al. Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide. 2005 BMC Genomics pmid:16150148
Génard M and Gouble B ETHY. A theory of fruit climacteric ethylene emission. 2005 Plant Physiol. pmid:16143642
Fernandez-Gomez FJ et al. Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death. 2005 Neurobiol. Dis. pmid:16242643
Mitreva M et al. Investigating hookworm genomes by comparative analysis of two Ancylostoma species. 2005 BMC Genomics pmid:15854223
Arthur CJ et al. Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein. 2005 Biochemistry pmid:16285746
Mokhova EN and Khailova LS Involvement of mitochondrial inner membrane anion carriers in the uncoupling effect of fatty acids. 2005 Biochemistry Mosc. pmid:15807654
Nie X and Wang G Synthesis of a ring-oxygenated variant of the 2-carboxy-6-hydroxyoctahydroindole core of aeruginosin 298-A from glucose. 2005 J. Org. Chem. pmid:16238296
Bozdech Z and Ginsburg H Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes. 2005 Malar. J. pmid:15774020
Hurth MA et al. Impaired pH homeostasis in Arabidopsis lacking the vacuolar dicarboxylate transporter and analysis of carboxylic acid transport across the tonoplast. 2005 Plant Physiol. pmid:15728336
Darvesh AS et al. Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. 2005 J. Pharmacol. Exp. Ther. pmid:15456837
Larson SB et al. Crystallographic structure of the T=1 particle of brome mosaic virus. 2005 J. Mol. Biol. pmid:15713465
Xiao R et al. Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. 2005 Mol. Cancer pmid:15644144
Fatland BL et al. Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis. 2005 Plant Cell pmid:15608338
Orosa M et al. Analysis and enhancement of astaxanthin accumulation in Haematococcus pluvialis. 2005 Bioresour. Technol. pmid:15474940
Darvesh AS and Gudelsky GA Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT. 2005 Brain Res. pmid:16098955
Baby SM et al. Role of mitochondria in the regulation of hypoxia-inducible factor-1alpha in the rat carotid body glomus cells. 2005 Histochem. Cell Biol. pmid:16034640
Lorenc-Koci E et al. 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity. 2005 Brain Res. pmid:16004976
Wycherley G et al. Oxidative phosphorylation and the tricarboxylic acid cycle are essential for normal development of mouse ovarian follicles. 2005 Hum. Reprod. pmid:16006477
Kachlicki P et al. Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. 2005 J Mass Spectrom pmid:15971291
Wang J et al. Coexistence of two bifurcation regimes in a closed ferroin-catalyzed Belousov-Zhabotinsky reaction. 2005 J Phys Chem A pmid:16833454
Kitahata H et al. Propagation of photosensitive chemical waves on the circular routes. 2005 J Phys Chem A pmid:16833846
Haas R et al. Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase. 2004 Appl. Microbiol. Biotechnol. pmid:14564485
Wu Q et al. LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans. 2004 J. Agric. Food Chem. pmid:15137811
Hopwood DA Cracking the polyketide code. 2004 PLoS Biol. pmid:14966534
Stieglitz K et al. Monitoring the transition from the T to the R state in E.coli aspartate transcarbamoylase by X-ray crystallography: crystal structures of the E50A mutant enzyme in four distinct allosteric states. 2004 J. Mol. Biol. pmid:15288791
Romanowski MJ et al. Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. 2004 Structure pmid:15296730
Nelson J et al. Steric complementarity in carboxylate anion recognition. 2004 Dalton Trans pmid:15356717
Maciel EN et al. Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition. 2004 J. Neurochem. pmid:15312158
Gołembiowska K and Dziubina A Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. 2004 Neuropharmacology pmid:15275831
Kanki R et al. Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. 2004 Brain Res. pmid:15223368
Fleck J et al. Intrastriatal malonate administration induces convulsive behaviour in rats. 2004 J. Inherit. Metab. Dis. pmid:15159652
Ekaratanawong S et al. Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. 2004 J. Pharmacol. Sci. pmid:15037815
Maragos WF et al. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. 2004 Neurochem. Res. pmid:15098936
Fleming I and Ramarao C Decarboxylative elimination of enol triflates as a general synthesis of acetylenes. 2004 Org. Biomol. Chem. pmid:15136807
Baud S et al. gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase. 2004 EMBO Rep. pmid:15088065
Shiva S et al. Mechanisms of the interaction of nitroxyl with mitochondria. 2004 Biochem. J. pmid:14723605
Paucard A et al. Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatum. 2004 Eur. J. Pharmacol. pmid:14729115
Maklashina E et al. Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart. 2004 FEBS Lett. pmid:14706827
Nam NH et al. Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. 2004 Bioorg. Med. Chem. pmid:14759738
Huber R et al. Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices. 2004 J. Neurosci. Res. pmid:14743458
Zalups RK and Ahmad S Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. 2004 J. Am. Soc. Nephrol. pmid:15284288
Wang H and Shooter D Low molecular weight dicarboxylic acids in PM10 in a city with intensive solid fuel burning. 2004 Chemosphere pmid:15251287
Zalups RK et al. Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. 2004 Kidney Int. pmid:15200431
Zhang YQ and Keller NP Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans. 2004 Mol. Microbiol. pmid:15066039
Chen H and Harrison PH Investigation of the origin of C2 units in biosynthesis of streptolydigin. 2004 Org. Lett. pmid:15496092
Cawthon D et al. Investigation of proton conductance in liver mitochondria of broilers with pulmonary hypertension syndrome. 2004 Poult. Sci. pmid:14979578
Scholte AA et al. Synthesis and biological activity of isopentenyl diphosphate analogues. 2004 Bioorg. Med. Chem. pmid:14759736
Ohtsuki S et al. Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. 2004 J. Pharmacol. Exp. Ther. pmid:14762099
Dickschat JS et al. Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. 2004 Chembiochem pmid:15174160
Chovancek M et al. Development of a fully buffered molybdate electrolyte for capillary electrophoresis with indirect detection and its use for analysis of anions in Bayer liquor. 2004 Electrophoresis pmid:14760635
Kiss C et al. Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. 2004 Brain Res. pmid:14988042
Comer E et al. Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. 2004 J. Am. Chem. Soc. pmid:15584744
Solano-Serena F et al. Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. 2004 J. Appl. Microbiol. pmid:15281945
Le Visage C et al. Efficacy of paclitaxel released from bio-adhesive polymer microspheres on model superficial bladder cancer. 2004 J. Urol. pmid:14767342
Morland C et al. Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. 2004 J. Cereb. Blood Flow Metab. pmid:15545916
Cornet S et al. Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline. 2004 Eur. J. Pharmacol. pmid:15556143
Klivenyi P et al. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. 2004 J. Neurochem. pmid:15009635
Murphy RC and Messer A A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease. 2004 Brain Res. Mol. Brain Res. pmid:14969746
Kucera LS et al. Synthesis and evaluation of a novel synthetic phosphocholine lipid-AZT conjugate that double-targets wild-type and drug resistant variants of HIV. 2004 Nucleosides Nucleotides Nucleic Acids pmid:15043162
Asanuma T et al. Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method. 2004 Neurosci. Lett. pmid:15050711
De Stefano C et al. Binding of fluoride and carbonate by open chain polyammonium cations. 2004 Talanta pmid:18969633
Liu SY et al. Calix[4]arenes containing thiourea and amide moieties: neutral receptors towards alpha,omega-dicarboxylate anions. 2004 Org. Biomol. Chem. pmid:15162208
Puchowicz MA et al. Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria--case studies. 2004 Mitochondrion pmid:16120399
Towler CS et al. Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'. 2004 J. Am. Chem. Soc. pmid:15479091
Yang L et al. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. 2004 Neurobiol. Dis. pmid:15474362
Magwene PM and Kim J Estimating genomic coexpression networks using first-order conditional independence. 2004 Genome Biol. pmid:15575966
Thatcher GR et al. Novel nitrates as NO mimetics directed at Alzheimer's disease. 2004 J. Alzheimers Dis. pmid:15665418
Yurgel SN and Kahn ML Dicarboxylate transport by rhizobia. 2004 FEMS Microbiol. Rev. pmid:15374663
Bufetov EN et al. [Effect of malonate on the structural and functional changes of wheat Triticum aestivum L. root cells]. 2004 Tsitologiia pmid:15704878
Ohshima T Enantioselective total syntheses of several bioactive natural products based on the development of practical asymmetric catalysis. 2004 Chem. Pharm. Bull. pmid:15340187
Chou HC et al. Multiple hydrogen bonds tuning guest/host excited-state proton transfer reaction: its application in molecular recognition. 2004 J. Am. Chem. Soc. pmid:14871093
Burckhardt BC et al. Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3. 2004 Cell. Physiol. Biochem. pmid:15319545
Stock I et al. Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. 2004 Clin. Microbiol. Infect. pmid:15301675
Jeong J et al. A nodule-specific dicarboxylate transporter from alder is a member of the peptide transporter family. 2004 Plant Physiol. pmid:15001700
Toulmond S et al. Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease. 2004 Br. J. Pharmacol. pmid:14744804
Kato F and Hiroi K Stereochemistry of the asymmetric carbopalladation of allenes followed by nucleophilic substitution reactions with carbo- and aminonucleophiles. 2004 Chem. Pharm. Bull. pmid:14709874
Miyata N et al. Enzymatic formation of manganese oxides by an Acremonium-like hyphomycete fungus, strain KR21-2. 2004 FEMS Microbiol. Ecol. pmid:19712351
Ma HW et al. Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. 2004 BMC Bioinformatics pmid:15603590
Taniguchi Y et al. Differentiation of dicarboxylate transporters in mesophyll and bundle sheath chloroplasts of maize. 2004 Plant Cell Physiol. pmid:14988489
de Rijke E et al. Liquid chromatography coupled to nuclear magnetic resonance spectroscopy for the identification of isoflavone glucoside malonates in T. pratense L. leaves. 2004 J Sep Sci pmid:15495407
Furin A et al. Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates. 2003 Jul-Aug Eur J Med Chem pmid:12932905
Fancellu R et al. Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum. 2003 Neurol. Sci. pmid:14598076
Alfinito PD et al. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. 2003 J. Neurosci. pmid:14645494
Holyoak T et al. Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals. 2003 Acta Crystallogr. D Biol. Crystallogr. pmid:14646118
Shigematsu T et al. Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge. 2003 Int. J. Syst. Evol. Microbiol. pmid:13130036
Coyle B et al. Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. 2003 Biometals pmid:12572690
Wang SC et al. Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: consequences of and evidence for a hydration reaction. 2003 Biochemistry pmid:12873137