Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Nerve Degeneration D009410 53 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Insulin Resistance D007333 99 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Kim MI et al. In vitro precursor-directed synthesis of polyketide analogues with coenzyme a regeneration for the development of antiangiogenic agents. 2009 Org. Lett. pmid:19653678
Salinero KK et al. Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation. 2009 BMC Genomics pmid:19650930
Karakikes I et al. Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. 2009 PLoS ONE pmid:19649297
Wong HR et al. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. 2009 BMC Med pmid:19624809
Gu J et al. Genomic and systems evolution in Vibrionaceae species. 2009 BMC Genomics pmid:19594870
Vaughan AM et al. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. 2009 Cell. Microbiol. pmid:19068099
Brown AK et al. Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases. 2009 PLoS ONE pmid:19609444
Casale A et al. Sequestration of Alkyltin(IV) compounds in aqueous solution: formation, stability, and empirical relationships for the binding of dimethyltin(IV) cation by N- and O-donor ligands. 2009 Bioinorg Chem Appl pmid:19590597
Cohen A et al. From the Gla domain to a novel small-molecule detector of apoptosis. 2009 Cell Res. pmid:19223854
Pistollato F et al. Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells. 2009 PLoS ONE pmid:19587783
Seppet E et al. Mitochondria and energetic depression in cell pathophysiology. 2009 Int J Mol Sci pmid:19564950
Bryan CG et al. Carbon and arsenic metabolism in Thiomonas strains: differences revealed diverse adaptation processes. 2009 BMC Microbiol. pmid:19549320
Kumasaka T et al. Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase. 2009 J. Biol. Chem. pmid:19546224
Parker N et al. Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. 2009 Biochim. Biophys. Acta pmid:19539600
Garcia-Ortiz JE et al. Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. 2009 BMC Dev. Biol. pmid:19538736
Feliciano I et al. Water-soluble molybdenocene complexes with both proliferative and antiproliferative effects on cancer cell lines and their binding interactions with human serum albumin. 2009 J. Biol. Inorg. Chem. pmid:19536567
Gianchandani EP et al. Functional states of the genome-scale Escherichia coli transcriptional regulatory system. 2009 PLoS Comput. Biol. pmid:19503608
Mallajosyula JK et al. Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. 2009 Neurotox Res pmid:19526285
Khalil S and Alsanius BW Utilisation of carbon sources by pythium, phytophthora and fusarium species as determined by biolog® microplate assay. 2009 Open Microbiol J pmid:19294012
Vesterdal LK et al. Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis. 2009 Part Fibre Toxicol pmid:19243580
Hellweg C et al. The time course of the transcriptomic response of Sinorhizobium meliloti 1021 following a shift to acidic pH. 2009 BMC Microbiol. pmid:19216801
Adhikari BN et al. Desiccation survival in an Antarctic nematode: molecular analysis using expressed sequenced tags. 2009 BMC Genomics pmid:19203352
Oberto J et al. The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction. 2009 PLoS ONE pmid:19194530
Rachid S et al. Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens. 2009 Chem. Biol. pmid:19171307
Jørgensen TR et al. Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway. 2009 BMC Genomics pmid:19166577
Tiziani S et al. Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines. 2009 PLoS ONE pmid:19158949
Zipse H et al. Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. 2009 J. Am. Chem. Soc. pmid:19128178
Tran QT et al. Chemical genomics of cancer chemopreventive dithiolethiones. 2009 Carcinogenesis pmid:19126641
Elliott JM et al. Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. 2009 J. Biol. Chem. pmid:19117953
Zeng WL et al. 3-[(5-Methyl-furan-2-yl)methyl-ene]-1,5-dioxaspiro-[5.5]undecane-2,4-dione. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583701
Zeng WL and Jian FF 3-(2-Furylmethyl-ene)-1,5-dioxaspiro-[5.5]undecane-2,4-dione. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583569
Soleimannejad J et al. Poly[μ(2)-aqua-aqua-μ(4)-pyridine-2,4-dicarboxyl-ato-strontium]. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583378
Liang WX et al. Oxonium 2-carb-oxy-3-(2-fur-yl)acrylate. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583167
Li XZ et al. 2-Carb-oxy-1-phenyl-ethanaminium perchlorate. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583083
Yan HY et al. Aqua-(propane-dioato-κO,O)[2-(1H-pyrazol-1-yl-κN)-1,10-phenanthroline-κN,N']nickel(II) trihydrate. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583013
Tang LM et al. catena-Poly[[diaquacobalt(II)]-bis(μ-3-carboxy-adamantane-1-carboxyl-ato-κO:O)]. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21582328
Subashini R et al. 2,4-Dichloro-6-methoxy-quinoline. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21581968
Yang SX et al. catena-Poly[[aqua-trimethyl-tin(IV)]-{[trimethyl-tin(IV)]-μ(3)-thio-phene-2,5-dicarboxyl-ato}]. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21581753
Shi H 4-(4-Chloro-phen-yl)-7,7-dimethyl-7,8-dihydro-4H-1-benzopyran-2,5(3H,6H)-dione. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21580158
Strieter ER et al. Cascade reactions during coronafacic acid biosynthesis: elongation, cyclization, and functionalization during Cfa7-catalyzed condensation. 2009 J. Am. Chem. Soc. pmid:19199623
Seno K et al. Determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow-injection analysis based on a specific condensation reaction between malonic acid and ethylenediamine. 2009 Anal Sci pmid:19276596
Ditzel J and Lervang HH Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials. 2009 Diabetes Metab Syndr Obes pmid:21437131
Gupta M et al. Hydroxyapatite supported caesium carbonate as a new recyclable solid base catalyst for the Knoevenagel condensation in water. 2009 Beilstein J Org Chem pmid:20300501
Burow LC et al. Induction of membrane permeability in Escherichia coli mediated by lysis protein of the ColE7 operon. 2009 FEMS Microbiol. Lett. pmid:19673051
Xie Z et al. Modules of co-regulated metabolites in turmeric (Curcuma longa) rhizome suggest the existence of biosynthetic modules in plant specialized metabolism. 2009 J. Exp. Bot. pmid:19073964
Innocenti A et al. Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. 2009 Bioorg. Med. Chem. pmid:19297172
Hoffman DL and Brookes PS Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. 2009 J. Biol. Chem. pmid:19366681
Burow LC et al. Anaerobic central metabolic pathways active during polyhydroxyalkanoate production in uncultured cluster 1 Defluviicoccus enriched in activated sludge communities. 2009 FEMS Microbiol. Lett. pmid:19622073
Choudhury SR et al. Robust recognition of malonate and 2-amino-4-picolinium in conjunction with M(II) as a triad (M = Ni/Co/Mn): role of this highly stable hydrogen-bonded motif in driving supramolecular self-assembly. 2009 Dalton Trans pmid:19759933
Okrasa K et al. Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases. 2009 Angew. Chem. Int. Ed. Engl. pmid:19739187
YarbaÅŸi Z et al. An EPR and optical absorption study of Cu(2+) doped in disodium malonate trihydrate single crystal. 2009 Spectrochim Acta A Mol Biomol Spectrosc pmid:19041279
Chace DH et al. Quantification of malonylcarnitine in dried blood spots by use of MS/MS varies by stable isotope internal standard composition. 2009 Clin. Chim. Acta pmid:19041298
Hassan HA et al. 1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain. 2009 Bioorg. Med. Chem. pmid:19147368
Sagredo O et al. Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease. 2009 Glia pmid:19115380
Miglio G et al. PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. 2009 Neurochem. Int. pmid:19442697
Duan S et al. Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters. 2009 J. Org. Chem. pmid:19518152
Morrison HG et al. Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles. 2009 Int J Pharm pmid:19477257
Su KL et al. Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme. 2009 Bioorg. Med. Chem. pmid:19595601
Borutaite V et al. Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release. 2009 J. Biomed. Sci. pmid:19671187
Honda A et al. Highly sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS. 2009 J. Lipid Res. pmid:19403942
Niwayama S and Cho H Practical large scale synthesis of half-esters of malonic acid. 2009 Chem. Pharm. Bull. pmid:19420784
Liu Z et al. Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. 2009 Phytother Res pmid:19277974
Lukyanova LD et al. Energotropic effect of succinate-containing derivatives of 3-hydroxypyridine. 2009 Bull. Exp. Biol. Med. pmid:20396747
Yuan X et al. Disordered plane waves in the transition between target and antitarget patterns. 2009 Phys Rev E Stat Nonlin Soft Matter Phys pmid:20365248
Hoffman HE et al. Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. 2009 J. Med. Chem. pmid:19791805
Tsubogo T et al. Chiral calcium catalysts with neutral coordinative ligands: enantioselective 1,4-addition reactions of 1,3-dicarbonyl compounds to nitroalkenes. 2009 Angew. Chem. Int. Ed. Engl. pmid:19862785
Yang L et al. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. 2009 PLoS ONE pmid:19484125
Blaquiere N et al. Decarboxylative ketone aldol reactions: development and mechanistic evaluation under metal-free conditions. 2009 J. Org. Chem. pmid:20560569
Schmelz S et al. AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. 2009 Nat. Chem. Biol. pmid:19182782
Yadav AV et al. Co-crystals: a novel approach to modify physicochemical properties of active pharmaceutical ingredients. 2009 Indian J Pharm Sci pmid:20502540
Dalla-Betta P and Schulte M Calculation of the aqueous thermodynamic properties of citric acid cycle intermediates and precursors and the estimation of high temperature and pressure equation of state parameters. 2009 Int J Mol Sci pmid:19582231
Ewais HA et al. Inner-sphere oxidation of ternary iminodiacetatochromium(III) complexes involving DL-valine and L-arginine as secondary ligands. Isokinetic relationship for the oxidation of ternary iminodiacetato-chromium(III) complexes by periodate. 2009 Chem Cent J pmid:19193241
Djavani M et al. Gene expression in primate liver during viral hemorrhagic fever. 2009 Virol. J. pmid:19216742
Tonouchi A Isolation and characterization of a novel facultative anaerobic filamentous fungus from Japanese rice field soil. 2009 Int J Microbiol pmid:20148171
Foret J et al. Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases. 2009 Bioorg. Med. Chem. pmid:19783448
Arambula JF et al. Gadolinium texaphyrin (Gd-Tex)-malonato-platinum conjugates: synthesis and comparison with carboplatin in normal and Pt-resistant cell lines. 2009 Dalton Trans pmid:20023913
Pieretti I et al. The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae. 2009 BMC Genomics pmid:20017926
Partha R and Conyers JL Biomedical applications of functionalized fullerene-based nanomaterials. 2009 Int J Nanomedicine pmid:20011243
Qureshi IA et al. Crystallographic structure of ubiquitin in complex with cadmium ions. 2009 BMC Res Notes pmid:20003470
Hamilton S et al. The transcriptional programme of Salmonella enterica serovar Typhimurium reveals a key role for tryptophan metabolism in biofilms. 2009 BMC Genomics pmid:20003355
Gebhard S et al. The low-affinity phosphate transporter PitA is dispensable for in vitro growth of Mycobacterium smegmatis. 2009 BMC Microbiol. pmid:20003273
Spindler M et al. Coenzyme Q10 effects in neurodegenerative disease. 2009 Neuropsychiatr Dis Treat pmid:19966907
Chovatia M et al. Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883). 2009 Stand Genomic Sci pmid:21304665
Azuma Y and Ota M An evaluation of minimal cellular functions to sustain a bacterial cell. 2009 BMC Syst Biol pmid:19943949
Tan Y et al. Effects of precursor concentration and acidic sulfate in aqueous glyoxal-OH radical oxidation and implications for secondary organic aerosol. 2009 Environ. Sci. Technol. pmid:19924930
Spinks D et al. Investigation of trypanothione reductase as a drug target in Trypanosoma brucei. 2009 ChemMedChem pmid:19924760
Pin C et al. Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase. 2009 BMC Syst Biol pmid:19917103
Bar NS and Radde N Long-term prediction of fish growth under varying ambient temperature using a multiscale dynamic model. 2009 BMC Syst Biol pmid:19903354
Xu XM et al. Dual localized AtHscB involved in iron sulfur protein biogenesis in Arabidopsis. 2009 PLoS ONE pmid:19865480
Ramel C et al. Biosynthesis of the proteasome inhibitor syringolin A: the ureido group joining two amino acids originates from bicarbonate. 2009 BMC Biochem. pmid:19863801
Perrot O et al. Quantitative assessment of stereotyped and challenged locomotion after lesion of the striatum: a 3D kinematic study in rats. 2009 PLoS ONE pmid:19859550
Baldwin A et al. Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes. 2009 BMC Microbiol. pmid:19852808
Kozjak-Pavlovic V et al. Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. 2009 PLoS Pathog. pmid:19851451
Strickler MA et al. Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. 2009 Biochim. Biophys. Acta pmid:19840771
Goldstein P et al. Clustering of protein domains for functional and evolutionary studies. 2009 BMC Bioinformatics pmid:19832975
Senoglu M et al. Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve. 2009 J Brachial Plex Peripher Nerve Inj pmid:19939272
Juhnke HD et al. Production, characterization and determination of the real catalytic properties of the putative 'succinate dehydrogenase' from Wolinella succinogenes. 2009 Mol. Microbiol. pmid:19170876
Emamzadah S et al. Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction. 2009 Acta Crystallogr. D Biol. Crystallogr. pmid:19690369
Yesilirmak F and Sayers Z Heterelogous expression of plant genes. 2009 Int J Plant Genomics pmid:19672459
Yang L et al. Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. 2009 Neurobiol. Dis. pmid:19660549