| MeSH term | MeSH ID | Detail |
|---|---|---|
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Mitochondrial Diseases | D028361 | 25 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aliverdieva DA et al. | Topography of the active site of the Saccharomyces cerevisiae plasmalemmal dicarboxylate transporter studied using lipophilic derivatives of its substrates. | 2007 | Biochemistry Mosc. | pmid:17447879 |
| Markova OV et al. | The anion-carrier mediated uncoupling effect of dicarboxylic fatty acids in liver mitochondria depends on the position of the second carboxyl group. | 1999 | Biochemistry Mosc. | pmid:10381619 |
| Chakraborty B et al. | Stage specific developmental changes in the mitochondrial and surface membrane associated redox systems of Leishmania donovani promastigote and amastigote. | 2010 | Biochemistry Mosc. | pmid:20618140 |
| Mokhova EN and Khailova LS | Involvement of mitochondrial inner membrane anion carriers in the uncoupling effect of fatty acids. | 2005 | Biochemistry Mosc. | pmid:15807654 |
| Aliverdieva DA et al. | Specific features of changes in levels of endogenous respiration substrates in Saccharomyces cerevisiae cells at low temperature. | 2006 | Biochemistry Mosc. | pmid:16457616 |
| Emery T | Malonichrome, a new iron chelate from Fusarium roseum. | 1980 | Biochim. Biophys. Acta | pmid:7388041 |
| Tihanyi K et al. | Effect of succinate on aminopyrine N-demethylase activity. | 1980 | Biochim. Biophys. Acta | pmid:7388048 |
| Parker N et al. | Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. | 2009 | Biochim. Biophys. Acta | pmid:19539600 |
| Latipää PM et al. | Regulation of palmitoylcarnitine oxidation in isolated rat liver mitochondria. Role of the redox state of NAD(H). | 1986 | Biochim. Biophys. Acta | pmid:3002483 |
| Gellerman JL et al. | Synthesis of anacardic acids in seeds of Ginkgo biloba. | 1976 | Biochim. Biophys. Acta | pmid:1268241 |
| Giorgio V et al. | The effects of idebenone on mitochondrial bioenergetics. | 2012 | Biochim. Biophys. Acta | pmid:22086148 |
| Susheela L et al. | Structural and kinetic studies on the activators of succinate dehydrogenase. | 1977 | Biochim. Biophys. Acta | pmid:188480 |
| Yasaka T and Kambara T | Different effects of concanavalin A and its succinylated derivative on superoxide release in peritoneal macrophages. | 1979 | Biochim. Biophys. Acta | pmid:222348 |
| Kotova EA et al. | Selective permeabilization of lipid membranes by photodynamic action via formation of hydrophobic defects or pre-pores. | 2011 | Biochim. Biophys. Acta | pmid:21663731 |
| Ilan Y et al. | Partitioning of electrostatic and conformational contributions in the redox reactions of modified cytochromes c. | 1979 | Biochim. Biophys. Acta | pmid:228716 |
| Aleksandrowicz Z and Sweirczyński J | The inhibition by bromothymol blue of anion translocation across the mitochondrial membrane. | 1975 | Biochim. Biophys. Acta | pmid:235323 |
| Kotlyar AB and Vinogradov AD | Interaction of the membrane-bound succinate dehydrogenase with substrate and competitive inhibitors. | 1984 | Biochim. Biophys. Acta | pmid:6691982 |
| Calderon P et al. | In vitro lipid metabolism in the rat pancreas. II. Effects of secretagogues on fatty acid metabolism, net lipolysis and ATP levels. | 1979 | Biochim. Biophys. Acta | pmid:486518 |
| Barros-Miñones L et al. | Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. | 2013 | Biochim. Biophys. Acta | pmid:23415811 |
| Wojtovich AP and Brookes PS | The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning. | 2008 Jul-Aug | Biochim. Biophys. Acta | pmid:18433712 |
| Palmieri F et al. | Mechanism of inhibition of the dicarboxylate carrier of mitochondria by thiol reagents. | 1974 | Biochim. Biophys. Acta | pmid:19400032 |
| Klimek J et al. | The relationship between energy generation and cholesterol side-chain cleavage reaction in the mitochondria from human term placenta. | 1979 | Biochim. Biophys. Acta | pmid:549647 |
| Kim YS and Kolattukudy PE | Malonyl-CoA decarboxylase from the mammary gland of lactating rat. Purification, properties and subcellular localization. | 1978 | Biochim. Biophys. Acta | pmid:718970 |
| Bindoli A et al. | Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by succinate. | 1982 | Biochim. Biophys. Acta | pmid:6289887 |
| Meigs RA and Sheean LA | Mitochondria from human term placenta. III. The role of respiration and energy generation in progesterone biosynthesis. | 1977 | Biochim. Biophys. Acta | pmid:922026 |
| Iacopetta D et al. | A novel subfamily of mitochondrial dicarboxylate carriers from Drosophila melanogaster: biochemical and computational studies. | 2011 | Biochim. Biophys. Acta | pmid:21130726 |
| Vinogradov AD et al. | Studies on the succinate dehydrogenating system. I. Kinetics of the succinate dehydrogenase interaction with a semiquindiimine radical of N,N,N',N'-tetramethyl-p-phenylenediamine. | 1979 | Biochim. Biophys. Acta | pmid:31933 |
| Aime S et al. | NMR and luminescence studies on the formation of ternary adducts between HSA and Ln(III)-malonate complexes. | 1998 | Biochim. Biophys. Acta | pmid:9630476 |
| Kolaj-Robin O et al. | Biochemical and biophysical characterization of succinate: quinone reductase from Thermus thermophilus. | 2011 | Biochim. Biophys. Acta | pmid:20951673 |
| Chen M and Zhu QS | Rapid redox equilibrium between the mitochondrial Q pool and cytochrome b during triphasic reduction of cytochrome b by succinate. | 1986 | Biochim. Biophys. Acta | pmid:3019394 |
| Calderon-Attas P et al. | In vitro effects of ethanol and ethanol metabolism in the rat pancreas. | 1980 | Biochim. Biophys. Acta | pmid:6165387 |
| Indiveri C et al. | Kinetics of the reconstituted dicarboxylate carrier from rat liver mitochondria. | 1989 | Biochim. Biophys. Acta | pmid:2804097 |
| Duszyński J et al. | Homeostasis of the protonmotive force in phosphorylating mitochondria. | 1984 | Biochim. Biophys. Acta | pmid:6095904 |
| Malviya AN et al. | Observations on the oxidoreduction of the two cytochromes b in cytochrome c-deficient mitochondria and submitochondrial particles. | 1980 | Biochim. Biophys. Acta | pmid:6243963 |
| Eriksson B et al. | Pyrophosphate analogues as inhibitors of herpes simplex virus type 1 DNA polymerase. | 1980 | Biochim. Biophys. Acta | pmid:6245699 |
| Zoratti M et al. | ATP synthase-mediated proton fluxes and phosphorylation in rat liver mitochondria: dependence on delta mu H. | 1986 | Biochim. Biophys. Acta | pmid:2873837 |
| Worsham LM et al. | Chemical cross-linking and its effect on fatty acid synthetase activity in intact chloroplasts from Euglena gracilis. | 1988 | Biochim. Biophys. Acta | pmid:3143414 |
| Lançar-Benba J et al. | Purification of the rat-liver mitochondrial dicarboxylate carrier by affinity chromatography on immobilized malate dehydrogenase. | 1994 | Biochim. Biophys. Acta | pmid:8142418 |
| Carlsen BD et al. | Synthesis of malate from phosphoenolpyruvate by rabbit liver mitochondria: implications for lipogenesis. | 1988 | Biochim. Biophys. Acta | pmid:2831992 |
| Woelders H et al. | Unique relationships between the rates of oxidation and phosphorylation and the protonmotive force in rat-liver mitochondria. | 1988 | Biochim. Biophys. Acta | pmid:2837288 |
| Halestrap AP | Glucagon treatment of rats activates the respiratory chain of liver mitochondria at more than one site. | 1987 | Biochim. Biophys. Acta | pmid:3028493 |
| Taylor RW et al. | Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. | 1993 | Biochim. Biophys. Acta | pmid:8391327 |
| Liou YF et al. | Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells. | 1983 | Biochim. Biophys. Acta | pmid:6824673 |
| Rigoulet M et al. | Redistribution of the flux-control coefficients in mitochondrial oxidative phosphorylations in the course of brain edema. | 1988 | Biochim. Biophys. Acta | pmid:3337798 |
| Kunz WS | Evaluation of electron-transfer flavoprotein and alpha-lipoamide dehydrogenase redox states by two-channel fluorimetry and its application to the investigation of beta-oxidation. | 1988 | Biochim. Biophys. Acta | pmid:3337800 |
| Cecchini G et al. | Succinate dehydrogenase and fumarate reductase from Escherichia coli. | 2002 | Biochim. Biophys. Acta | pmid:11803023 |
| Janausch IG et al. | C4-dicarboxylate carriers and sensors in bacteria. | 2002 | Biochim. Biophys. Acta | pmid:11803016 |
| Szewczyk A et al. | Purification by affinity chromatography of the dicarboxylate carrier from bovine heart mitochondria. | 1987 | Biochim. Biophys. Acta | pmid:3676300 |
| Guerranti R et al. | Inhibition and regulation of rat liver L-threonine dehydrogenase by different fatty acids and their derivatives. | 2001 | Biochim. Biophys. Acta | pmid:11731084 |
| Strickler MA et al. | Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. | 2009 | Biochim. Biophys. Acta | pmid:19840771 |
| Huang LS et al. | Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state. | 2006 Sep-Oct | Biochim. Biophys. Acta | pmid:16935256 |
| Luévano-MartÃnez LA et al. | Identification of the mitochondrial carrier that provides Yarrowia lipolytica with a fatty acid-induced and nucleotide-sensitive uncoupling protein-like activity. | 2010 | Biochim. Biophys. Acta | pmid:19766093 |
| Strasser de Saad AM et al. | Malolactic enzyme in Lactobacillus murinus. | 1988 | Biochimie | pmid:3139053 |
| Belgorodsky B et al. | Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex. | 2005 Sep-Oct | Bioconjug. Chem. | pmid:16173780 |
| Ndinguri MW et al. | Peptide targeting of platinum anti-cancer drugs. | 2009 | Bioconjug. Chem. | pmid:19775102 |
| Blank M and Soo L | Electromagnetic acceleration of the Belousov-Zhabotinski reaction. | 2003 | Bioelectrochemistry | pmid:14642914 |
| Okano H et al. | The Influence of a gradient static magnetic field on an unstirred Belousov-Zhabotinsky reaction. | 2008 | Bioelectromagnetics | pmid:18512693 |
| SamoÄlov VO et al. | [Two molecular motility systems of the frog olfactory cilia]. | 2008 Nov-Dec | Biofizika | pmid:19137683 |
| de Groot MJ et al. | Metabolite and reaction inference based on enzyme specificities. | 2009 | Bioinformatics | pmid:19696044 |
| Casale A et al. | Sequestration of Alkyltin(IV) compounds in aqueous solution: formation, stability, and empirical relationships for the binding of dimethyltin(IV) cation by N- and O-donor ligands. | 2009 | Bioinorg Chem Appl | pmid:19590597 |
| Singh SK et al. | Coal Depolymerising Activity and Haloperoxidase Activity of Mn Peroxidase from Fomes durissimus MTCC-1173. | 2011 | Bioinorg Chem Appl | pmid:22162670 |
| Devereux M et al. | Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 | Bioinorg Chem Appl | pmid:17497019 |
| Shoukry EM | Equilibrium and kinetic investigations of the interaction of model platinum(II) complex with DNA constituents in reference to the antitumour activity: complex-formation reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with ligands of biological significance and displacement reactions of DNA constituents. | 2009 | Bioinorg Chem Appl | pmid:19696935 |
| Denisenko TV et al. | [Decarboxylation of malonyl-CoA and biosynthesis of mevalonic acid in rat liver]. | 1979 | Biokhimiia | pmid:454714 |
| GubnitskiÄ LS et al. | [Kinetics of fumarate hydratase reaction catalyzed by free cells of Escherichia coli]. | 1981 | Biokhimiia | pmid:7018596 |
| Bekina RM and Lebedeva AF | [Studies of oxygen uptake (Mehler reactions) in chloroplasts in the presence of silico-molybdic acid]. | 1977 | Biokhimiia | pmid:870090 |
| Klimov AN et al. | [Does malonate take part in the synthesis of sterols?]. | 1990 | Biokhimiia | pmid:1972338 |
| Kotliar AB and Vinogradov AD | [Interaction of succinate dehydrogenase and oxaloacetate]. | 1984 | Biokhimiia | pmid:6733163 |
| Belikova IuO and Kotliar AB | [Malate oxidation by mitochondrial succinate:ubiquinone-reductase]. | 1988 | Biokhimiia | pmid:3395646 |
| Kotliar AB and Vinogradov AD | [Dissociation constants of succinate dehydrogenase complexes with succinate, fumarate and malonate]. | 1984 | Biokhimiia | pmid:6722218 |
| Glaus M and Schneider W | Iron release from transferrin induced by mixed ligand complexes of copper(II). | 1989 | Biol Met | pmid:2490073 |
| Saris NE | On the mechanism of rebounding of calcium in liver mitochondria. | 1997 | Biol. Chem. | pmid:9372185 |
| Kunz WS | Application of the theory of steady-state flux control to mitochondrial beta-oxidation. | 1991 | Biomed. Biochim. Acta | pmid:1668635 |
| Coyle B et al. | Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. | 2003 | Biometals | pmid:12572690 |
| Nam NH et al. | Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. | 2004 | Bioorg. Med. Chem. | pmid:14759738 |
| Desvergnes S et al. | Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase. | 2012 | Bioorg. Med. Chem. | pmid:22269276 |
| Braud E et al. | Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. | 2008 | Bioorg. Med. Chem. | pmid:18789703 |
| Innocenti A et al. | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. | 2009 | Bioorg. Med. Chem. | pmid:19297172 |
| Hassan HA et al. | 1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain. | 2009 | Bioorg. Med. Chem. | pmid:19147368 |
| Kalaitzis JA et al. | Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. | 2011 | Bioorg. Med. Chem. | pmid:21531566 |
| Su KL et al. | Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme. | 2009 | Bioorg. Med. Chem. | pmid:19595601 |
| Wang R et al. | A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. | 1997 | Bioorg. Med. Chem. | pmid:9158864 |
| Scholte AA et al. | Synthesis and biological activity of isopentenyl diphosphate analogues. | 2004 | Bioorg. Med. Chem. | pmid:14759736 |
| Marinier A et al. | Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates. | 2001 | Bioorg. Med. Chem. | pmid:11408160 |
| Duez S et al. | Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues. | 2010 | Bioorg. Med. Chem. | pmid:20036564 |
| Foret J et al. | Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases. | 2009 | Bioorg. Med. Chem. | pmid:19783448 |
| Cowen D et al. | A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20034791 |
| Innocenti A et al. | Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15664815 |
| Liu Z et al. | A facile solid phase synthesis of tetramic acid. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12852953 |
| Agarwal HK et al. | Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22858097 |
| Crossin MC et al. | Perturbation of ribosome subunit interaction by glutaraldehyde fixation. | 1984 | Biophys. Chem. | pmid:6435698 |
| Marek M and Stuchl I | Synchronization in two interacting oscillatory systems. | 1975 | Biophys. Chem. | pmid:1174646 |
| Marek M and Svobodová E | Nonlinear phenomena in oscillatory systems of homogeneous reactions - experimental observations. | 1975 | Biophys. Chem. | pmid:1174649 |
| Bergene R and Melo TB | Free radicals in malonic acid: a study of radical conformations at 77K and 295K by the ESR-technique. | 1972 | Biophysik | pmid:4346520 |
| Issabayeva G et al. | Removal of lead from aqueous solutions on palm shell activated carbon. | 2006 | Bioresour. Technol. | pmid:16321520 |
| Orosa M et al. | Analysis and enhancement of astaxanthin accumulation in Haematococcus pluvialis. | 2005 | Bioresour. Technol. | pmid:15474940 |
| Kita T et al. | The biosynthetic pathway of curcuminoid in turmeric (Curcuma longa) as revealed by 13C-labeled precursors. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18603793 |
| Kamo T et al. | Changes in the content and biosynthesis of phytoalexins in banana fruit. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129580 |
| Baek JG et al. | Metabolite profiling of Cheonggukjang, a fermented soybean paste, inoculated with various Bacillus strains during fermentation. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20834151 |
| Kim SH et al. | Metabolic profiling and predicting the free radical scavenging activity of guava (Psidium guajava L.) leaves according to harvest time by 1H-nuclear magnetic resonance spectroscopy. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21670527 |