Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Neoplasms, Muscle Tissue D009379 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Barros-Miñones L et al. Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. 2013 Biochim. Biophys. Acta pmid:23415811
Bew SP et al. Malonic acid half oxyesters and thioesters: solvent-free synthesis and DFT analysis of their enols. 2013 Org. Lett. pmid:23876089
Chen WN and Tan KY "Malonate uptake and metabolism in Saccharomyces cerevisiae". 2013 Appl. Biochem. Biotechnol. pmid:23813405
Li J et al. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. 2013 Protein Cell pmid:23807634
Zhou S et al. Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans. 2013 Biotechnol. Bioeng. pmid:23775313
Minato Y et al. Malonate inhibits virulence gene expression in Vibrio cholerae. 2013 PLoS ONE pmid:23675480
Zhang X et al. Atomic force microscopy study of the effects of water-soluble fullerenes on the elasticity of living plant cells. 2013 Chem Asian J pmid:23929723
Valdeolivas S et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. 2013 Cell Death Dis pmid:24136226
Yuan HN et al. Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: synthesis of β-amino esters and anti-HIV drug DPC 083. 2013 Chemistry pmid:24150893
Barros-Miñones L et al. Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. 2013 Br. J. Pharmacol. pmid:23186227