| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abscess | D000038 | 13 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Edema | D004487 | 152 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oyedotun KS and Lemire BD | The Saccharomyces cerevisiae succinate-ubiquinone reductase contains a stoichiometric amount of cytochrome b562. | 1999 | FEBS Lett. | pmid:9929002 |
| Hoenke S and Dimroth P | Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected]. | 1999 | Eur. J. Biochem. | pmid:9914491 |
| Bruce-Keller AJ et al. | Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. | 1999 | Ann. Neurol. | pmid:9894871 |
| Maragos WF et al. | 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. | 1998 | Exp. Neurol. | pmid:9878198 |
| Gao J et al. | Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. | 1999 | J. Lipid Res. | pmid:9869665 |
| Matharu AL et al. | MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. | 1998 | Chem. Biol. | pmid:9862793 |
| Kolb S et al. | The fermenting bacterium Malonomonas rubra is phylogenetically related to sulfur-reducing bacteria and contains a c-type cytochrome similar to those of sulfur and sulfate reducers. | 1998 | Syst. Appl. Microbiol. | pmid:9841124 |
| An JH and Kim YS | A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli. | 1998 | Eur. J. Biochem. | pmid:9826185 |
| Zeevalk GD et al. | Excitotoxicity and oxidative stress during inhibition of energy metabolism. | 1998 | Dev. Neurosci. | pmid:9778583 |
| Simonyan RA and Skulachev VP | Thermoregulatory uncoupling in heart muscle mitochondria: involvement of the ATP/ADP antiporter and uncoupling protein. | 1998 | FEBS Lett. | pmid:9771898 |
| Rutkoski A and Jaworski JG | An improved synthesis of malonyl-coenzyme A. | 1978 | Anal. Biochem. | pmid:9762122 |
| Bonkowsky HL and Pomeroy JS | Assay of delta-aminolevulinic acid synthetase in homogenates of mouse, rat, and human liver: species differences in requirement for an exogenous succinyl-CoA-generating system. | 1978 | Anal. Biochem. | pmid:9762086 |
| Hofrichter M et al. | Oxidative decomposition of malonic acid as basis for the action of manganese peroxidase in the absence of hydrogen peroxide. | 1998 | FEBS Lett. | pmid:9742955 |
| Hariharan M and Allewell NM | Effects of the T-->R transition on the electrostatic properties of E. coli aspartate transcarbamylase. | 1998 | Proteins | pmid:9714159 |
| Gregg AR et al. | Combined malonic and methylmalonic aciduria with normal malonyl-coenzyme A decarboxylase activity: a case supporting multiple aetiologies. | 1998 | J. Inherit. Metab. Dis. | pmid:9700595 |
| Prorok M and Castellino FJ | Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T. | 1998 | J. Biol. Chem. | pmid:9677382 |
| Aime S et al. | NMR and luminescence studies on the formation of ternary adducts between HSA and Ln(III)-malonate complexes. | 1998 | Biochim. Biophys. Acta | pmid:9630476 |
| Cox RB and Quayle JR | Synthesis and hydrolysis of malyl-coenzyme A by Pseudomonas AM1: an apparent malate synthase activity. | 1976 | J. Gen. Microbiol. | pmid:956773 |
| Yu HL et al. | Stimulation of ammonia production and excretion in the rabbit by inorganic phosphate. Study of control mechanisms. | 1976 | J. Clin. Invest. | pmid:956385 |
| Lecanu L et al. | Deleterious Ca-independent NOS activity after oxidative stress in rat striatum. | 1998 | Neuroreport | pmid:9512406 |
| Buyukgebiz B et al. | Fatal neonatal malonic aciduria. | 1998 | J. Inherit. Metab. Dis. | pmid:9501274 |
| Williams DM et al. | Role of copper in mitochondrial iron metabolism. | 1976 | Blood | pmid:947406 |
| Zalups RK and Barfuss DW | Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9465278 |
| Graf von Roedern E et al. | Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). | 1998 | J. Med. Chem. | pmid:9464365 |
| Willis CL et al. | Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. | 1997 | Curr. Microbiol. | pmid:9462959 |
| Matthews RT et al. | Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. | 1998 | J. Neurosci. | pmid:9412496 |
| Sonsalla PK et al. | Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra. | 1997 | Brain Res. | pmid:9409726 |
| van der Spoel D and Berendsen HJ | Determination of proton transfer rate constants using Ab initio, molecular dynamics and density matrix evolution calculations. | 1996 | Pac Symp Biocomput | pmid:9390263 |
| Saris NE | On the mechanism of rebounding of calcium in liver mitochondria. | 1997 | Biol. Chem. | pmid:9372185 |
| Korshunov SS et al. | High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. | 1997 | FEBS Lett. | pmid:9369223 |
| Guyot MC et al. | Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats. | 1997 | Neuroscience | pmid:9300407 |
| Beal MF and Matthews RT | Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. | 1997 | Mol. Aspects Med. | pmid:9266519 |
| Garcia-Delgado GA et al. | A comparison of various Haemophilus somnus strains. | 1977 | Can. J. Comp. Med. | pmid:922555 |
| Meigs RA and Sheean LA | Mitochondria from human term placenta. III. The role of respiration and energy generation in progesterone biosynthesis. | 1977 | Biochim. Biophys. Acta | pmid:922026 |
| Hoenke S et al. | Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli. | 1997 | Eur. J. Biochem. | pmid:9208947 |
| Yano S et al. | A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopathy. | 1997 | Eur. J. Pediatr. | pmid:9177981 |
| Wang R et al. | A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. | 1997 | Bioorg. Med. Chem. | pmid:9158864 |
| Magliozzo RS and Marcinkeviciene JA | The role of Mn(II)-peroxidase activity of mycobacterial catalase-peroxidase in activation of the antibiotic isoniazid. | 1997 | J. Biol. Chem. | pmid:9083004 |
| Zeevalk GD et al. | In vivo vulnerability of dopamine neurons to inhibition of energy metabolism. | 1997 | Eur. J. Pharmacol. | pmid:9059843 |
| Affourtit C et al. | Kinetic interaction between oxidases and dehydrogenases in plant mitochondria. | 1997 | Biochem. Soc. Trans. | pmid:9056958 |
| Matthews RT et al. | S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. | 1997 | Exp. Neurol. | pmid:9056390 |
| Connop BP et al. | Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole. | 1997 | J. Neurochem. | pmid:9048766 |
| Woods KM et al. | Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. | 1996 | Ann Trop Med Parasitol | pmid:9039272 |
| Wada H et al. | Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9037098 |
| Chien LF and Brand MD | The effect of chloroform on mitochondrial energy transduction. | 1996 | Biochem. J. | pmid:9003370 |
| Zeevalk GD et al. | Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures. | 1997 | J. Neurochem. | pmid:8978755 |
| Borutaite V et al. | Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia. | 1996 | J. Mol. Cell. Cardiol. | pmid:8930814 |
| Hu JZ et al. | High resolution 1H spectra of powdered solids observed by Hahn echo pulse sequence with magic-angle spinning. | 1996 | Solid State Nucl Magn Reson | pmid:8925269 |
| Geddes JW et al. | Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. | 1996 May-Aug | Mol. Chem. Neuropathol. | pmid:8871943 |
| Podell M et al. | Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy. | 1996 | Metab Brain Dis | pmid:8869944 |