Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Malonic acid?

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What functions are associated with Malonic acid?


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What lipids are associated with Malonic acid?

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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Klejnot M and Kozielski F Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. 2012 Acta Crystallogr. D Biol. Crystallogr. pmid:22281744
Holyoak T et al. Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals. 2003 Acta Crystallogr. D Biol. Crystallogr. pmid:14646118
Alcorn T and Juers DH Progress in rational methods of cryoprotection in macromolecular crystallography. 2010 Acta Crystallogr. D Biol. Crystallogr. pmid:20382989
Snell EH et al. Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples. 2008 Acta Crystallogr. D Biol. Crystallogr. pmid:19020351
Vaezeslami S et al. Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding. 2008 Acta Crystallogr. D Biol. Crystallogr. pmid:19018099
Hu TC et al. High-molecular-weight polymers for protein crystallization: poly-gamma-glutamic acid-based precipitants. 2008 Acta Crystallogr. D Biol. Crystallogr. pmid:18703844
Nurmohamed S et al. Molecular recognition between Escherichia coli enolase and ribonuclease E. 2010 Acta Crystallogr. D Biol. Crystallogr. pmid:20823555
Emamzadah S et al. Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction. 2009 Acta Crystallogr. D Biol. Crystallogr. pmid:19690369
Verma SK et al. Structure of N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) from Mycobacterium tuberculosis in a cubic space group. 2009 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:19407371
Jackson CJ et al. Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. 2008 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:18678932
Phan I et al. Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria. 2011 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:21904061
Abendroth J et al. BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative β-lactamase-like protein' from Brucella melitensis. 2011 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:21904058
Davies DR et al. An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. 2011 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:21904048
Trinh CH et al. Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans. 2008 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:19052361
Axelrod HL et al. Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris. 2010 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:20944231
Schneider S et al. Crystallization and X-ray diffraction analysis of the DNA-remodelling protein DnaD from Bacillus subtilis. 2007 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:17277452
Jackson CJ et al. The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes. 2006 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:16820687
Chhabra S et al. Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. 2010 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:20445263
Saraswathi NT and Vijayan M X-ray studies on crystalline complexes involving amino acids and peptides. XXXIX. Crystal structures of malonic acid complexes of DL- and L-histidine. Preservation of aggregation pattern on reversal of chirality. 2002 Acta Crystallogr., B pmid:12149565
Saraswathi NT and Vijayan M X-ray studies on crystalline complexes involving amino acids and peptides. XL. Conformational variability, recurring and new features of aggregation, and effect of chirality in the malonic acid complexes of DL- and L-arginine. 2002 Acta Crystallogr., B pmid:12456986
Dey SK et al. Pentose phosphate pathway and steroidogenesis in the immature rat ovary after malonate treatment. 1972 Acta Endocrinol. pmid:4677789
Dey SK et al. Testicular dehydrogenases in toads after malonate treatment. 1971 Acta Histochem. pmid:4998164
Tóth V and Emódy L Proteus virulence: involvement of the pore forming alpha-hemolysin (a short review). 2000 Acta Microbiol Immunol Hung pmid:11056765
DiMauro S Pathogenesis and treatment of mitochondrial myopathies: recent advances. 2010 Acta Myol pmid:21314015
Søgaard P and Kjaeldgaard P Two isolations of enteric group 69 from human clinical specimens. 1986 Acta Pathol Microbiol Immunol Scand B pmid:3788575
FORSSMAN S and LINDSTEN T A contribution to the pharmacodynamics of malonic, succinic, citric, aconitic, alpha-ketoglutaric and glutamic acid. 1946 Acta Pharmacol Toxicol (Copenh) pmid:20295477
Dobosz M et al. Synthesis of new derivatives of 3-benzyl-4-R-delta 2-1,2,4-triazolin-5-one and 3,3'-methylidyne bis(4-R-1,2,4-delta 2-triazolin-5-one). 2000 May-Jun Acta Pol Pharm pmid:11143710
Biaglow J et al. Factors controlling oxygen utilization. 2005 Adv. Exp. Med. Biol. pmid:16594168
Berthon G et al. Histamine as a ligand in blood plasma. Part 7. Malate, malonate, maleate and tartrate as adjuvants of zinc to favour histamine tissue diffusion through mixed-ligand coordination. In vitro tests on lymphocyte proliferation. 1987 Agents Actions pmid:3445819
McDowell EM Light and electron microscopic studies of rat kidney after administration of inhibitors of the citric acid cycle in vivo. II. Effects of sodium malonate on proximal convoluted tubule. 1972 Am. J. Pathol. pmid:5061663
Tallitsch RB Further observations of aldosterone response in barnacle muscle fibers. 1983 Am. J. Physiol. pmid:6614162
Oldendorf WH et al. Transient blood-brain barrier passage of polar compounds at low pH. 1994 Am. J. Physiol. pmid:7810722
Gougoux A et al. Maleate-induced bicarbonaturia in the dog: a carbonic anhydrase-independene effect. 1976 Am. J. Physiol. pmid:10734
Scaduto RC and Schoolwerth AC Effect of bicarbonate on glutamine and glutamate metabolism by rat kidney cortex mitochondria. 1985 Am. J. Physiol. pmid:2864861
Simpson DP Citrate excretion: a window on renal metabolism. 1983 Am. J. Physiol. pmid:6338740
Yu XX et al. Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18198353
Ozcan C et al. Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11788400
Hardin CD et al. Myocardial metabolism of exogenous FDP is consistent with transport by a dicarboxylate transporter. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11709435
Sweet DH et al. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. 2003 Am. J. Physiol. Renal Physiol. pmid:12488248
Hering-Smith KS et al. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. 2011 Am. J. Physiol. Renal Physiol. pmid:21123491
Burckhardt BC et al. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. 2005 Am. J. Physiol. Renal Physiol. pmid:15561973
Kaufhold M et al. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3. 2011 Am. J. Physiol. Renal Physiol. pmid:21865262
Kamga CK et al. Dicarboxylate carrier-mediated glutathione transport is essential for reactive oxygen species homeostasis and normal respiration in rat brain mitochondria. 2010 Am. J. Physiol., Cell Physiol. pmid:20538765
Li JV et al. Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections. 2011 Am. J. Trop. Med. Hyg. pmid:21212208
Han C et al. Photo-induced cold vapor generation with low molecular weight alcohol, aldehyde, or carboxylic acid for atomic fluorescence spectrometric determination of mercury. 2007 Anal Bioanal Chem pmid:17216165
MacCrehan WA and White CM Simplified ultrasonically- and microwave-assisted solvent extractions for the determination of ginsenosides in powdered Panax ginseng rhizomes using liquid chromatography with UV absorbance or electrospray mass spectrometric detection. 2013 Anal Bioanal Chem pmid:23564283
Ruhaak LR et al. Glycan labeling strategies and their use in identification and quantification. 2010 Anal Bioanal Chem pmid:20225063
Seno K et al. Determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow-injection analysis based on a specific condensation reaction between malonic acid and ethylenediamine. 2009 Anal Sci pmid:19276596
Tamaya K et al. Interpretation of solute retention of some monovalent inorganic anions in anion-exchange chromatography using a dicarboxylic Acid as an eluent. 2006 Anal Sci pmid:16770050
Chen SC Fluorometric determination of malonic acid with dicyclohexylcarbodiimide. 1984 Anal. Biochem. pmid:6486406
Reszko AE et al. Assay of the concentration and 13C-isotopic enrichment of malonyl-coenzyme A by gas chromatography-mass spectrometry. 2001 Anal. Biochem. pmid:11673897
Lane DJ and Lawen A A highly sensitive colorimetric microplate ferrocyanide assay applied to ascorbate-stimulated transplasma membrane ferricyanide reduction and mitochondrial succinate oxidation. 2008 Anal. Biochem. pmid:17949676
Byun HS and Kim YS Assays for malonate decarboxylase. 1994 Anal. Biochem. pmid:7695096
Kim YS and Bang SK Assays for malonyl-coenzyme A synthase. 1988 Anal. Biochem. pmid:3389517
Bonkowsky HL and Pomeroy JS Assay of delta-aminolevulinic acid synthetase in homogenates of mouse, rat, and human liver: species differences in requirement for an exogenous succinyl-CoA-generating system. 1978 Anal. Biochem. pmid:9762086
Rutkoski A and Jaworski JG An improved synthesis of malonyl-coenzyme A. 1978 Anal. Biochem. pmid:9762122
Pisarenko AN et al. Rapid analysis of perchlorate, chlorate and bromate ions in concentrated sodium hypochlorite solutions. 2010 Anal. Chim. Acta pmid:20103127
Dey SK and Deb C Effect of sodium malonate on ovarian dehydrogenases. A histochemical study. 1972 Anat Anz pmid:5063563
RULON O The modification of developmental patterns in Arbacia eggs with malonic acid. 1947 Anat. Rec. pmid:18895450
Piasecka M et al. Computerized analysis of cytochemical reactions for dehydrogenases and oxygraphic studies as methods to evaluate the function of the mitochondrial sheath in rat spermatozoa. 2001 Andrologia pmid:11167513
McCooey SH and Connon SJ Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance. 2005 Angew. Chem. Int. Ed. Engl. pmid:16136619
Zhao L and Li CJ Functionalizing glycine derivatives by direct C-C bond formation. 2008 Angew. Chem. Int. Ed. Engl. pmid:18671311
Okrasa K et al. Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases. 2009 Angew. Chem. Int. Ed. Engl. pmid:19739187
Bao X et al. A chemical probe for lysine malonylation. 2013 Angew. Chem. Int. Ed. Engl. pmid:23533089
Tsubogo T et al. Chiral calcium catalysts with neutral coordinative ligands: enantioselective 1,4-addition reactions of 1,3-dicarbonyl compounds to nitroalkenes. 2009 Angew. Chem. Int. Ed. Engl. pmid:19862785
Hoye TR et al. Allylmalonate as an activator subunit for the initiation of relay ring-closing metathesis reactions. 2011 Angew. Chem. Int. Ed. Engl. pmid:21344570
Lubkoll J and Wennemers H Mimicry of polyketide synthases--enantioselective 1,4-addition reactions of malonic acid half-thioesters to nitroolefins. 2007 Angew. Chem. Int. Ed. Engl. pmid:17680584
Colsenet R et al. A straightforward detection of deprotonated conformers of malonic acid by solid-state 13C NMR spectroscopy. 2002 Angew. Chem. Int. Ed. Engl. pmid:12481345
Shama SA Determination of the thermodynamic parameters and stability constants of UO2(2+), Th4+, and Ce3+ complexes with some azo-benzene-N-malonic acid derivatives. 2001 May-Jun Ann Chim pmid:11507839
Woods KM et al. Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. 1996 Ann Trop Med Parasitol pmid:9039272
Richard C et al. [Phenotype characteristics of 100 strains of Pseudomonas cepacia. Proposition of a biovars classification (author's transl)]. 1981 Ann. Biol. Clin. (Paris) pmid:7212403
Calaf R et al. [Critical study of the determination of urinary oxalic acid by gas chromatography]. 1982 Ann. Biol. Clin. (Paris) pmid:7165137
Malvagia S et al. Fatal malonyl CoA decarboxylase deficiency due to maternal uniparental isodisomy of the telomeric end of chromosome 16. 2007 Ann. Hum. Genet. pmid:17535268
Le Minor L et al. [Characterization of a 7th subspecies of Salmonella: S. choleraesuis subsp. indica subsp. nov]. 1986 Sep-Oct Ann. Inst. Pasteur Microbiol. pmid:3689588
Johnson JA et al. The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. 2008 Ann. N. Y. Acad. Sci. pmid:19076431
Donaldson WE Biotin effects on fatty acid synthesis in chicks. 1985 Ann. N. Y. Acad. Sci. pmid:2861776
Maragos WF et al. Does dopamine contribute to striatal damage caused by impaired mitochondrial function? 1999 Ann. N. Y. Acad. Sci. pmid:10672263
Bruce-Keller AJ et al. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. 1999 Ann. Neurol. pmid:9894871
Beal MF et al. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. 1994 Ann. Neurol. pmid:7998775
Nefelova MV et al. [Nonactin biosynthesis. The incorporation of precursors into the antibiotic molecule]. 1985 Antibiot. Med. Biotekhnol. pmid:3840667
Hall IH et al. Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpene lactones. 1988 Jan-Feb Anticancer Res. pmid:2895992
van der Kooij D et al. Multiplication of fluorescent pseudomonads at low substrate concentrations in tap water. 1982 Antonie Van Leeuwenhoek pmid:6127053
Dehning I and Schink B Anaerobic degradation of malonate via malonyl-CoA by Sporomusa malonica, Klebsiella oxytoca, and Rhodobacter capsulatus. 1994 Antonie Van Leeuwenhoek pmid:7710283
Stevens P and van Elsas JD Genetic and phenotypic diversity of Ralstonia solanacearum biovar 2 strains obtained from Dutch waterways. 2010 Antonie Van Leeuwenhoek pmid:19960250
Grimberg H et al. Monitoring of tumor response to chemotherapy in vivo by a novel small-molecule detector of apoptosis. 2009 Apoptosis pmid:19172398
Blazevic DJ et al. Evaluation of the PathoTec "Rapid I-D System". 1973 Appl Microbiol pmid:4588196
Rae IC et al. Utilization of iron gallate and other organic iron complexes by bacteria from water supplies. 1973 Appl Microbiol pmid:4716725
Zheng GH et al. Feasibility of 2,4,6-trichlorophenol and malonic acid as metabolic uncoupler for sludge reduction in the sequence batch reactor for treating organic wastewater. 2008 Appl. Biochem. Biotechnol. pmid:18456942
Chen WN and Tan KY "Malonate uptake and metabolism in Saccharomyces cerevisiae". 2013 Appl. Biochem. Biotechnol. pmid:23813405
Perez J and Jeffries TW Role of organic acid chelators in manganese regulation of lignin degradation by Phanerochaete chrysosporium. 1993 Appl. Biochem. Biotechnol. pmid:8323262
Perez J and Jeffries TW Roles of manganese and organic acid chelators in regulating lignin degradation and biosynthesis of peroxidases by Phanerochaete chrysosporium. 1992 Appl. Environ. Microbiol. pmid:1514788
Russell JB and Van Soest PJ In vitro ruminal fermentation of organic acids common in forage. 1984 Appl. Environ. Microbiol. pmid:6696413
Karunakaran R et al. Malonate catabolism does not drive N2 fixation in legume nodules. 2013 Appl. Environ. Microbiol. pmid:23666330
Haas R et al. Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase. 2004 Appl. Microbiol. Biotechnol. pmid:14564485
Roa Engel CA et al. Fumaric acid production by fermentation. 2008 Appl. Microbiol. Biotechnol. pmid:18214471
Wang J et al. Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. 2017 Appl. Microbiol. Biotechnol. pmid:28175948
Gao X et al. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. 2010 Appl. Microbiol. Biotechnol. pmid:20853106
Balk M et al. (Per)chlorate reduction by an acetogenic bacterium, Sporomusa sp., isolated from an underground gas storage. 2010 Appl. Microbiol. Biotechnol. pmid:20680263
GRUBER CM et al. A toxicologic study of sodium malonate. 1949 Arch Int Pharmacodyn Ther pmid:18152910
Journet EP et al. Glutamate metabolism triggered by oxaloacetate in intact plant mitochondria. 1982 Arch. Biochem. Biophys. pmid:6123300