Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Neoplasms, Muscle Tissue D009379 2 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Teratoma D013724 4 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Abscess D000038 13 associated lipids
Neoplasms D009369 13 associated lipids
Ischemia D007511 18 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Brain Edema D001929 20 associated lipids
Hyperglycemia D006943 21 associated lipids
Bacterial Infections D001424 21 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Brain Diseases D001927 27 associated lipids
Catalepsy D002375 30 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Diarrhea D003967 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Memory Disorders D008569 33 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Liu D Poly[[μ(2)-1,2-bis-(4-pyrid-yl)ethene](μ(3)-1,3-phenyl-enediacetato)-cadmium]. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22219828
Li ZS and Ng SW catena-Poly[[[(2,2'-bipyridine-κN,N')cobalt(II)]-μ-(E)-3,3'-(but-2-ene-2,3-di-yl)dibenzoato-κO,O':O'',O'''] hemihydrate]. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22219789
Jiang GQ et al. Hexa-μ(2)-acetato-κO:O'-(azido-κN)bis-(methanol-κO)-μ(3)-oxido-trichromium(III) methanol monosolvate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22219738
Myking S et al. Candidate gene analysis of spontaneous preterm delivery: new insights from re-analysis of a case-control study using case-parent triads and control-mother dyads. 2011 BMC Med. Genet. pmid:22208904
Guo HM 5-tert-Butyl 3-ethyl 1-isopropyl-4,5,6,7-tetra-hydro-1H-pyrazolo-[4,3-c]pyridine-3,5-dicarboxyl-ate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22199750
Chen HR et al. Poly[[tetra-aqua-μ(4)-fumarato-di-μ(3)-fumarato-dineodymium(III)] trihydrate]. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22199526
Shi D et al. A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. 2011 PLoS ONE pmid:22174908
Schiff M et al. Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice. 2011 PLoS ONE pmid:22174907
Troxell B et al. The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets. 2011 BMC Microbiol. pmid:22017966
Merlino A et al. Improving protein crystal quality by the without-oil microbatch method: crystallization and preliminary X-ray diffraction analysis of glutathione synthetase from Pseudoalteromonas haloplanktis. 2011 Int J Mol Sci pmid:22016660
Sivagnanam K et al. Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose. 2011 Proteome Sci pmid:22008648
Pon J et al. Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control. 2011 Malar. J. pmid:22029897
Rajeev L et al. Systematic mapping of two component response regulators to gene targets in a model sulfate reducing bacterium. 2011 Genome Biol. pmid:21992415
Prakash M et al. Crystal growth, structural, optical, dielectric and thermal studies of an amino acid based organic NLO material: L-phenylalanine L-phenylalaninium malonate. 2011 Spectrochim Acta A Mol Biomol Spectrosc pmid:21943710
Zhao W et al. Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis. 2011 Mol Neurodegener pmid:21771318
Zeng WL 3-(2,4-Dichloro-benzyl-idene)-1,5-dioxa-spiro-[5.5]undecane-2,4-dione. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21754756
Zeng WL 5-(3,4-Dimethyl-benzyl-idene)-2,2-dimethyl-1,3-dioxane-4,6-dione. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21754745
Sy A et al. Poly[di-μ-aqua-diaqua-di-μ(6)-malonato-cobalt(II)dipotassium(I)]. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21754320
Zhou YH Di-μ-glutarato-κO:O-bis-[aqua-(1,10-phenanthroline-κN,N')copper(II)]. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21753943
Hutcheson SW et al. Carbohydrase systems of Saccharophagus degradans degrading marine complex polysaccharides. 2011 Mar Drugs pmid:21731555
Lim IT and Choi KY One-dimensional hydrogen-bonded infinite chain from nickel(II) tetraaza macrocyclic complex and 1,2-cyclopentanedicarboxylate ligand. 2011 Int J Mol Sci pmid:21731438
Brand MD and Nicholls DG Assessing mitochondrial dysfunction in cells. 2011 Biochem. J. pmid:21726199
Dharmarajan L et al. Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate. 2011 Proteins pmid:21491491
Matar-Merheb R et al. Structuring detergents for extracting and stabilizing functional membrane proteins. 2011 PLoS ONE pmid:21483854
Sorokin DY et al. Culturable diversity of lithotrophic haloalkaliphilic sulfate-reducing bacteria in soda lakes and the description of Desulfonatronum thioautotrophicum sp. nov., Desulfonatronum thiosulfatophilum sp. nov., Desulfonatronovibrio thiodismutans sp. nov., and Desulfonatronovibrio magnus sp. nov. 2011 Extremophiles pmid:21479878
Zhao J et al. MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. 2011 Plant Cell pmid:21467581
Ling AS et al. A zinc finger protein, TbZC3H20, stabilizes two developmentally regulated mRNAs in trypanosomes. 2011 J. Biol. Chem. pmid:21467035
Gallo M et al. MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion. 2011 PLoS ONE pmid:21448454
Kurakin A The self-organizing fractal theory as a universal discovery method: the phenomenon of life. 2011 Theor Biol Med Model pmid:21447162
Ramachandran VK et al. Adaptation of Rhizobium leguminosarum to pea, alfalfa and sugar beet rhizospheres investigated by comparative transcriptomics. 2011 Genome Biol. pmid:22018401
Iacopetta D et al. A novel subfamily of mitochondrial dicarboxylate carriers from Drosophila melanogaster: biochemical and computational studies. 2011 Biochim. Biophys. Acta pmid:21130726
Hering-Smith KS et al. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. 2011 Am. J. Physiol. Renal Physiol. pmid:21123491
Edwards TE et al. Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis. 2011 BMC Struct. Biol. pmid:21995815
Bondia-Pons I et al. Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread. 2011 Nutr J pmid:22011443
Vujčić M et al. A comparative study of DNA binding and cell cycle phase perturbation by the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide N',N'(2) -bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. 2011 May-Jun J. Biochem. Mol. Toxicol. pmid:21671309
Klejnot M and Kozielski F Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. 2012 Acta Crystallogr. D Biol. Crystallogr. pmid:22281744
Giorgio V et al. The effects of idebenone on mitochondrial bioenergetics. 2012 Biochim. Biophys. Acta pmid:22086148
Schlüter A et al. Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. 2012 Hum. Mol. Genet. pmid:22095690
Führs H et al. Functional associations between the metabolome and manganese tolerance in Vigna unguiculata. 2012 J. Exp. Bot. pmid:21934118
Kim SH et al. Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction. 2012 BMC Microbiol. pmid:22316246
Bonhomme C et al. 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. 2012 J. Am. Chem. Soc. pmid:22738329
Bauwens M et al. Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers. 2012 PLoS ONE pmid:22719886
Callahan DL et al. Elemental and metabolite profiling of nickel hyperaccumulators from New Caledonia. 2012 Phytochemistry pmid:22795763
Shevchenko A et al. A new cocrystal and salts of itraconazole: comparison of solid-state properties, stability and dissolution behavior. 2012 Int J Pharm pmid:22750429
Liu Q et al. Structural effect and mechanism of C70-carboxyfullerenes as efficient sensitizers against cancer cells. 2012 Small pmid:22508680
Mitra T et al. Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions. 2012 J Mater Sci Mater Med pmid:22367159
Ruiz M et al. A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. 2012 PLoS ONE pmid:23056435
Du X et al. [Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors]. 2012 Yao Xue Xue Bao pmid:22645761
Park SY et al. An analysis of the concentration change of intermediate metabolites by gene manipulation in fatty acid biosynthesis. 2012 Enzyme Microb. Technol. pmid:22664193
Liu Z et al. The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer. 2012 J Pharm Biomed Anal pmid:22387101
Ward RA et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. 2012 J. Med. Chem. pmid:22417091
Sand A et al. Synthesis of graft copolymer (CgOH-g-AGA): physicochemical properties, characterization and application. 2012 Carbohydr Polym pmid:22840018
Chojkier M et al. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. 2012 PLoS ONE pmid:22412837
Valdeolivas S et al. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors. 2012 ACS Chem Neurosci pmid:22860209
Batur M et al. Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. 2012 J Tradit Chin Med pmid:22594115
Martin FP et al. Metabolomic applications to decipher gut microbial metabolic influence in health and disease. 2012 Front Physiol pmid:22557976
Kubicek J et al. Controlled in meso phase crystallization--a method for the structural investigation of membrane proteins. 2012 PLoS ONE pmid:22536388
Yokoi T et al. Formation of octacalcium phosphates with co-incorporated succinate and suberate ions. 2012 Dalton Trans pmid:22249371
Yadav M et al. Synthesis, characterization and applications of graft copolymer (κ-carrageenan-g-vinylsulfonic acid). 2012 Int. J. Biol. Macromol. pmid:22142792
Luévano-Martínez LA et al. A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. 2012 Biochem. J. pmid:22236206
Chanumolu SK et al. UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. 2012 PLoS ONE pmid:22431985
Cui YH et al. Comparison of various organic compounds destruction on rare earths doped Ti/Sb-SnO2 electrodes. 2012 J. Hazard. Mater. pmid:23022412
Caricato M et al. Synthesis and anion recognition properties of shape-persistent binaphthyl-containing chiral macrocyclic amides. 2012 Beilstein J Org Chem pmid:23015847
Agarwal HK et al. Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors. 2012 Bioorg. Med. Chem. Lett. pmid:22858097
Manochitra P et al. Aqua-(2,2'-bipyridine-κ²N,N')(2-methyl-malonato-κ²O¹,O³)copper(II) dihydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22807729
Kokare BN et al. Development of a reliable analytical method for liquid anion-exchange extraction and separation of neodymium(III). 2012 ScientificWorldJournal pmid:22701373
Hagemann TL et al. Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival. 2012 PLoS ONE pmid:22693571
Thein M et al. DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. 2012 PLoS ONE pmid:22590556
Lapanje K et al. Bis(acetato-κO)bis-[2-(pyridin-2-yl)ethanol-κ(2)N,O]copper(II). 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22590106
Benkanoun A et al. Intra- and supra-molecular inter-actions in cis,mer-diaqua-tris-(1H-imidazole-κN(3))(terephthalato-κO)cobalt(II) monohydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22589841
Liew CW et al. Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis. 2012 J. Biol. Chem. pmid:22589546
Anand K et al. Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. 2012 PLoS ONE pmid:22574179
Moldes D et al. Role of laccase and low molecular weight metabolites from Trametes versicolor in dye decolorization. 2012 ScientificWorldJournal pmid:22566767
Tao X et al. Digital gene expression analysis based on integrated de novo transcriptome assembly of sweet potato [Ipomoea batatas (L.) Lam]. 2012 PLoS ONE pmid:22558397
Xiao L et al. Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. 2012 PLoS ONE pmid:22545152
Queiroga CS et al. Carbon monoxide targeting mitochondria. 2012 Biochem Res Int pmid:22536507
Engeham S et al. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet. 2012 J Nutr Metab pmid:22536494
Natarajan S et al. Crystal structure of L-histidinium 2-nitrobenzoate. 2012 J Amino Acids pmid:22536482
Scalliet G et al. Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. 2012 PLoS ONE pmid:22536383
Laurido C et al. Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model. 2012 ScientificWorldJournal pmid:22536130
Okoli AS et al. Effects of human and porcine bile on the proteome of Helicobacter hepaticus. 2012 Proteome Sci pmid:22533459
Pauly MC et al. Restoration of the striatal circuitry: from developmental aspects toward clinical applications. 2012 Front Cell Neurosci pmid:22529778
Nguyen Q et al. Rh2(II)-catalyzed intramolecular aliphatic C-H bond amination reactions using aryl azides as the N-atom source. 2012 J. Am. Chem. Soc. pmid:22519742
Chen Z et al. Applications of functionalized fullerenes in tumor theranostics. 2012 Theranostics pmid:22509193
Jin YW and Zhu HL Poly[[penta-aqua-(μ(4)-pyridine-2,4,6-tri-carboxyl-ato)(μ(3)-pyridine-2,4,6-tri-carboxyl-ato)disamarium(III)] mono-hydrate]. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22412433
Zhang XJ and Guo ML catena-Poly[[bis-(1-methyl-1H-imidazole-κN)zinc]-μ-3-nitro-phthalato-κO:O]. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22412416
Ashrafian H et al. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. 2012 Cell Metab. pmid:22405071
Trushina E et al. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. 2012 PLoS ONE pmid:22393443
Tran QM et al. Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase. 2012 PLoS ONE pmid:22393428
Totir M et al. Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. 2012 PLoS ONE pmid:22393408
Barker BM et al. Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. 2012 BMC Genomics pmid:22309491
Hackett NR et al. RNA-Seq quantification of the human small airway epithelium transcriptome. 2012 BMC Genomics pmid:22375630
Tovar-y-Romo LB and Tapia R Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo. 2012 ASN Neuro pmid:22369757
Zuno-Floriano FG et al. Effect of Acinetobacter sp on metalaxyl degradation and metabolite profile of potato seedlings (Solanum tuberosum L.) alpha variety. 2012 PLoS ONE pmid:22363586
Fujii T and Albarède F Ab initio calculation of the Zn isotope effect in phosphates, citrates, and malates and applications to plants and soil. 2012 PLoS ONE pmid:22363478
Frankel S and Rogina B Indy mutants: live long and prosper. 2012 Front Genet pmid:22363340
Wang N et al. Changes in soybean global gene expression after application of lipo-chitooligosaccharide from Bradyrhizobium japonicum under sub-optimal temperature. 2012 PLoS ONE pmid:22348109
Merewitz EB et al. Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation. 2012 J. Exp. Bot. pmid:22131157
Peng Y et al. Poly[[μ(2)-1,3-bis-(imidazol-1-ylmeth-yl)benzene][μ(2)-2,2'-dihy-droxy-1,1'-methyl-enebis(naphthalene-3-carboxyl-ato)]zinc]. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22346812
Vagner T et al. Nucleic Acid-Based Therapy Approaches for Huntington's Disease. 2012 Neurol Res Int pmid:22288011