Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Wang J et al. Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. 2017 Appl. Microbiol. Biotechnol. pmid:28175948
Xu JY et al. Lysine Malonylome May Affect the Central Metabolism and Erythromycin Biosynthesis Pathway in Saccharopolyspora erythraea. 2016 J. Proteome Res. pmid:27090497
Zubiría MG et al. Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model. 2016 Nutrients pmid:27384583
Chatnaparat T et al. Global Pattern of Gene Expression of Xanthomonas axonopodis pv. glycines Within Soybean Leaves. 2016 Mol. Plant Microbe Interact. pmid:27003800
Guan X and Nikolau BJ AAE13 encodes a dual-localized malonyl-CoA synthetase that is crucial for mitochondrial fatty acid biosynthesis. 2016 Plant J. pmid:26836315
Fu X et al. Malonate induces the assembly of cytoplasmic stress granules. 2016 FEBS Lett. pmid:26787461
Németh B et al. Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. 2016 FASEB J. pmid:26358042
Colak G et al. Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. 2015 Mol. Cell Proteomics pmid:26320211
Lewin R et al. Enzymatic enantioselective decarboxylative protonation of heteroaryl malonates. 2015 Chemistry pmid:25766433
Mukaida M et al. Stability order of caffeine co-crystals determined by co-crystal former exchange reaction and its application for the validation of in silico models. 2015 Chem. Pharm. Bull. pmid:25743190
Pandey MK et al. Composite-180° pulse-based symmetry sequences to recouple proton chemical shift anisotropy tensors under ultrafast MAS solid-state NMR spectroscopy. 2015 J. Magn. Reson. pmid:25497846
Akopova OV et al. [Estimation of ATP-dependent K(+)-channel contribution to potential-dependent potassium uptake in the rat brain mitochondria]. 2014 Jan-Feb Ukr Biochem J pmid:24834715
Zhang Y et al. Organic acids enhance bioavailability of tetracycline in water to Escherichia coli for uptake and expression of antibiotic resistance. 2014 Water Res. pmid:25100186
Stevens JS et al. Proton transfer and hydrogen bonding in the organic solid state: a combined XRD/XPS/ssNMR study of 17 organic acid-base complexes. 2014 Phys Chem Chem Phys pmid:24292812
Shibata N et al. Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids. 2014 Org. Biomol. Chem. pmid:24445698
Xiao D et al. Distinct effects of oxalate versus malonate on the iron redox chemistry: Implications for the photo-Fenton reaction. 2014 Chemosphere pmid:24359921
Aboudzadeh A et al. Ionic supramolecular networks fully based on chemicals coming from renewable sources. 2014 Macromol Rapid Commun pmid:24285575
Klopries S et al. Biosynthesis with fluorine. 2014 Chembiochem pmid:24504732
Borer P and Hug SJ Photo-redox reactions of dicarboxylates and α-hydroxydicarboxylates at the surface of Fe(III)(hydr)oxides followed with in situ ATR-FTIR spectroscopy. 2014 J Colloid Interface Sci pmid:24370400
Beyer KD et al. Temperature-dependent deliquescence relative humidities and water activities using humidity controlled thermogravimetric analysis with application to malonic acid. 2014 J Phys Chem A pmid:24628358
Hara Y et al. Generative force of self-oscillating gel. 2014 J Phys Chem B pmid:24524539
Preska Steinberg A et al. Target Turing patterns and growth dynamics in the chlorine dioxide-iodine-malonic acid reaction. 2014 J Phys Chem A pmid:24601764
Ghorai S et al. Hygroscopic properties of internally mixed particles composed of NaCl and water-soluble organic acids. 2014 Environ. Sci. Technol. pmid:24437520
Wang Y et al. Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers. 2014 Int J Clin Exp Pathol pmid:25120785
Gueguen C et al. Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition. 2014 PLoS ONE pmid:24586272
Barros-Miñones L et al. Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. 2013 Biochim. Biophys. Acta pmid:23415811
Bew SP et al. Malonic acid half oxyesters and thioesters: solvent-free synthesis and DFT analysis of their enols. 2013 Org. Lett. pmid:23876089
Chen WN and Tan KY "Malonate uptake and metabolism in Saccharomyces cerevisiae". 2013 Appl. Biochem. Biotechnol. pmid:23813405
Li J et al. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. 2013 Protein Cell pmid:23807634
Karunakaran R et al. Malonate catabolism does not drive N2 fixation in legume nodules. 2013 Appl. Environ. Microbiol. pmid:23666330
Belenki C et al. Cleavable surfactants to tune the stability of W/O miniemulsions. 2013 J Colloid Interface Sci pmid:23218239
Martins N et al. Changes on organic acid secretion and accumulation in Plantago almogravensis Franco and Plantago algarbiensis Samp. under aluminum stress. 2013 Plant Sci. pmid:23199681
Zheng P et al. Identification and validation of urinary metabolite biomarkers for major depressive disorder. 2013 Mol. Cell Proteomics pmid:23111923
Bao X et al. A chemical probe for lysine malonylation. 2013 Angew. Chem. Int. Ed. Engl. pmid:23533089
Kumar A et al. Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats. 2013 Eur. J. Pharmacol. pmid:23562615
MacCrehan WA and White CM Simplified ultrasonically- and microwave-assisted solvent extractions for the determination of ginsenosides in powdered Panax ginseng rhizomes using liquid chromatography with UV absorbance or electrospray mass spectrometric detection. 2013 Anal Bioanal Chem pmid:23564283
Darvas M et al. Molecular dynamics simulations of the water adsorption around malonic acid aerosol models. 2013 Phys Chem Chem Phys pmid:23702947
Zhou S et al. Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans. 2013 Biotechnol. Bioeng. pmid:23775313
Minato Y et al. Malonate inhibits virulence gene expression in Vibrio cholerae. 2013 PLoS ONE pmid:23675480
Zhang X et al. Atomic force microscopy study of the effects of water-soluble fullerenes on the elasticity of living plant cells. 2013 Chem Asian J pmid:23929723
Valdeolivas S et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. 2013 Cell Death Dis pmid:24136226
Yuan HN et al. Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: synthesis of β-amino esters and anti-HIV drug DPC 083. 2013 Chemistry pmid:24150893
Sundermann U et al. Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. 2013 ACS Chem. Biol. pmid:23181268
Barros-Miñones L et al. Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. 2013 Br. J. Pharmacol. pmid:23186227
Salem AA et al. Application of quantitative nuclear magnetic resonance spectroscopy for the determination ofamantadine and acyclovir in plasma and pharmaceutical samples. 2012 Nov-Dec J AOAC Int pmid:23451380
Mahendradas P et al. Unilateral conjunctival ulcer due to Stenotrophomonas maltophilia infection. 2012 Mar-Apr Indian J Ophthalmol pmid:22446910
Klejnot M and Kozielski F Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. 2012 Acta Crystallogr. D Biol. Crystallogr. pmid:22281744
Zhang YB et al. Geometry analysis and systematic synthesis of highly porous isoreticular frameworks with a unique topology. 2012 Nat Commun pmid:22273680
Iriyama N et al. Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. 2012 J Hematol Oncol pmid:22272800
Irizarry KJ et al. Sequencing and comparative genomic analysis of 1227 Felis catus cDNA sequences enriched for developmental, clinical and nutritional phenotypes. 2012 BMC Genomics pmid:22257742
Jang YJ et al. Tandem three-component reactions of aldehyde, alkyl acrylate, and dialkylmalonate catalyzed by ethyl diphenylphosphine. 2012 Molecules pmid:22446986
Führs H et al. Functional associations between the metabolome and manganese tolerance in Vigna unguiculata. 2012 J. Exp. Bot. pmid:21934118
Syu SE et al. Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates. 2012 Chirality pmid:22589149
Orellana A et al. A Diels-Alder-based total synthesis of (-)-kainic acid. 2012 J. Org. Chem. pmid:22551444
Amaral AU et al. Ethylmalonic acid impairs brain mitochondrial succinate and malate transport. 2012 Mol. Genet. Metab. pmid:22133302
Zhang YM et al. 5-Carb-oxy-1,3-bis-(carb-oxy-meth-yl)-4-imidazolinium-4-carboxyl-ate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22259512
Limwikrant W et al. Formation mechanism of a new carbamazepine/malonic acid cocrystal polymorph. 2012 Int J Pharm pmid:22537807
Desvergnes S et al. Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase. 2012 Bioorg. Med. Chem. pmid:22269276
Ghosh Dastidar T and Netravali AN 'Green' crosslinking of native starches with malonic acid and their properties. 2012 Carbohydr Polym pmid:22944425
Yang J et al. One-step hydrothermal synthesis of carboxyl-functionalized upconversion phosphors for bioapplications. 2012 Chemistry pmid:22996059
Ghosh SK et al. Highly enantioselective and recyclable organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in aqueous media. 2012 Org. Biomol. Chem. pmid:22976596
Bonhomme C et al. 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. 2012 J. Am. Chem. Soc. pmid:22738329
Bauwens M et al. Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers. 2012 PLoS ONE pmid:22719886
Chojkier M et al. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. 2012 PLoS ONE pmid:22412837
Rotstein HG and Wu H Swing, release, and escape mechanisms contribute to the generation of phase-locked cluster patterns in a globally coupled FitzHugh-Nagumo model. 2012 Phys Rev E Stat Nonlin Soft Matter Phys pmid:23368024
Batur M et al. Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. 2012 J Tradit Chin Med pmid:22594115
Wilhelm A et al. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept. 2012 J. Med. Chem. pmid:23106316
Zhu MC et al. Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(II) complex. 2012 Dalton Trans pmid:23001283
Li WS et al. Regulation of Turing patterns in a spatially extended chlorine-iodine-malonic-acid system with a local concentration-dependent diffusivity. 2012 Phys Rev E Stat Nonlin Soft Matter Phys pmid:23005187
Xue J et al. Novel compound heterozygous mutation of MLYCD in a Chinese patient with malonic aciduria. 2012 Mol. Genet. Metab. pmid:22104738
Maune MW and Tanner RS Description of Anaerobaculum hydrogeniformans sp. nov., an anaerobe that produces hydrogen from glucose, and emended description of the genus Anaerobaculum. 2012 Int. J. Syst. Evol. Microbiol. pmid:21602364
Chanumolu SK et al. UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. 2012 PLoS ONE pmid:22431985
Meyer KJ et al. Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. 2012 Mar Drugs pmid:22690150
Cui YH et al. Comparison of various organic compounds destruction on rare earths doped Ti/Sb-SnO2 electrodes. 2012 J. Hazard. Mater. pmid:23022412
Manochitra P et al. Aqua-(2,2'-bipyridine-κ²N,N')(2-methyl-malonato-κ²O¹,O³)copper(II) dihydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22807729
Kokare BN et al. Development of a reliable analytical method for liquid anion-exchange extraction and separation of neodymium(III). 2012 ScientificWorldJournal pmid:22701373
Hagemann TL et al. Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival. 2012 PLoS ONE pmid:22693571
Quinlan CL et al. Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. 2012 J. Biol. Chem. pmid:22689576
Ferramosca A et al. A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. 2012 PLoS ONE pmid:22685607
Finnegan PM and Chen W Arsenic toxicity: the effects on plant metabolism. 2012 Front Physiol pmid:22685440
Chen JW et al. Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress. 2012 PLoS ONE pmid:22675497
Khodadad CL and Foster JS Metagenomic and metabolic profiling of nonlithifying and lithifying stromatolitic mats of Highborne Cay, The Bahamas. 2012 PLoS ONE pmid:22662280
Michalski R et al. Application of hyphenated techniques in speciation analysis of arsenic, antimony, and thallium. 2012 ScientificWorldJournal pmid:22654649
Ariza AC et al. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. 2012 Front Endocrinol (Lausanne) pmid:22649411
Pittman JK Multiple Transport Pathways for Mediating Intracellular pH Homeostasis: The Contribution of H(+)/ion Exchangers. 2012 Front Plant Sci pmid:22645567
Haferkamp I and Schmitz-Esser S The plant mitochondrial carrier family: functional and evolutionary aspects. 2012 Front Plant Sci pmid:22639632
Tomita Y et al. Genome and transcriptome analysis of the food-yeast Candida utilis. 2012 PLoS ONE pmid:22629373
Thein M et al. DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. 2012 PLoS ONE pmid:22590556
Nguyen Q et al. Rh2(II)-catalyzed intramolecular aliphatic C-H bond amination reactions using aryl azides as the N-atom source. 2012 J. Am. Chem. Soc. pmid:22519742
Chen Z et al. Applications of functionalized fullerenes in tumor theranostics. 2012 Theranostics pmid:22509193
Begemann MB et al. A Streamlined Strategy for Biohydrogen Production with Halanaerobium hydrogeniformans, an Alkaliphilic Bacterium. 2012 Front Microbiol pmid:22509174
Gaster M Reduced TCA Flux in Diabetic Myotubes: Determined by Single Defects? 2012 Biochem Res Int pmid:22506116
Lushchak VI Glutathione homeostasis and functions: potential targets for medical interventions. 2012 J Amino Acids pmid:22500213
Vrabl P et al. Organic Acid Excretion in Penicillium ochrochloron Increases with Ambient pH. 2012 Front Microbiol pmid:22493592
Li C et al. Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm. 2012 J. Biol. Chem. pmid:22493500
Bouhlel A et al. New methodology for the synthesis of thiobarbiturates mediated by manganese(III) acetate. 2012 Molecules pmid:22491680
Russo Krauss I et al. Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data. 2012 Int J Mol Sci pmid:22489183
Shi L et al. Chlorine dioxide-iodide-methyl acetoacetate oscillation reaction investigated by UV-vis and online FTIR spectrophotometric method. 2012 ScientificWorldJournal pmid:22454614
Wong YH et al. Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. 2012 PLoS ONE pmid:22448242
Zhang H and Li M Transcriptional profiling of ESTs from the biocontrol fungus Chaetomium cupreum. 2012 ScientificWorldJournal pmid:22448129