Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
pmid:
Schulz JB et al. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. 1998 Cell Death Differ. pmid:10203688
Turnbull LB et al. Excretion and biotransformation of carboxymethyl-cysteine in rat, dog, monkey and man. 1978 Xenobiotica pmid:102086
Matthews RT et al. Novel free radical spin traps protect against malonate and MPTP neurotoxicity. 1999 Exp. Neurol. pmid:10222114
Chohnan S et al. Cloning and characterization of mdc genes encoding malonate decarboxylase from Pseudomonas putida. 1999 FEMS Microbiol. Lett. pmid:10339824
Lu GW et al. Alteration of oxygen consumption and energy metabolism during repetitive exposure of mice to hypoxia. 1999 Neurochem. Res. pmid:10344590
Markova OV et al. The anion-carrier mediated uncoupling effect of dicarboxylic fatty acids in liver mitochondria depends on the position of the second carboxyl group. 1999 Biochemistry Mosc. pmid:10381619
Maragos WF et al. Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. 1999 Brain Res. pmid:10407109
Kristensen JH et al. Separation of (2)H MAS NMR spectra by two-dimensional spectroscopy. 1999 J. Magn. Reson. pmid:10423369
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Lahnsteiner F et al. Sperm metabolism of the telost fishes Chalcalburnus chalcoides and Oncorhynchus mykiss and its relation to motility and viability. 1999 J. Exp. Zool. pmid:10451423
Ferger B et al. Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation. 1999 J. Neurochem. pmid:10461928
Moreno-Sánchez R et al. Determining and understanding the control of flux. An illustration in submitochondrial particles of how to validate schemes of metabolic control. 1999 Eur. J. Biochem. pmid:10491087
Handa S et al. Stereochemical course of biotin-independent malonate decarboxylase catalysis. 1999 Arch. Biochem. Biophys. pmid:10496981
O'Brien DP et al. Malonic aciduria in Maltese dogs: normal methylmalonic acid concentrations and malonyl-CoA decarboxylase activity in fibroblasts. 1999 J. Inherit. Metab. Dis. pmid:10604140
Hinz W et al. Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells. 1999 FEBS Lett. pmid:10622736
Klivenyi P et al. Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. 2000 J. Neurosci. pmid:10627575
Garle MJ et al. Stimulation of dichlorofluorescin oxidation by capsaicin and analogues in RAW 264 monocyte/macrophages: lack of involvement of the vanilloid receptor. 2000 Biochem. Pharmacol. pmid:10660122
Yang WC et al. Simultaneous determination of polycarboxylic acids by capillary electrophoresis with a copper electrode. 2000 J Chromatogr A pmid:10670726