Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Ramaseshan M et al. Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds. 2000 Nov-Dec J Comb Chem pmid:11126291
Nguyen TH et al. Conformations, energies, and intramolecular hydrogen bonds in dicarboxylic acids: implications for the design of synthetic dicarboxylic acid receptors. 2005 J Comput Chem pmid:15962275
Hidaka M and Yoshida R Self-oscillating gel composed of thermosensitive polymer exhibiting higher LCST. 2011 J Control Release pmid:21130818
Malik N et al. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. 2000 J Control Release pmid:10699277
Pritchard DJ Transdifferentiation of chicken embryo neural retina into pigment epithelium: indications of its biochemical basis. 1981 J Embryol Exp Morphol pmid:7276821
Walash MI et al. Determination of oxybutynin in pharmaceuticals via reaction with mixed acids anhydrides: application to content uniformity testing. 2011 J Fluoresc pmid:21046437
Josyula AB et al. Reduction in urinary arsenic with bottled-water intervention. 2006 J Health Popul Nutr pmid:17366771
Iriyama N et al. Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. 2012 J Hematol Oncol pmid:22272800
García Sabater JF et al. Taxonomic position of Klebsiella atlantae and Klebsiella edwardsii. 1979 J Hyg Epidemiol Microbiol Immunol pmid:393774
Kachlicki P et al. Evaluation of glycosylation and malonylation patterns in flavonoid glycosides during LC/MS/MS metabolite profiling. 2008 J Mass Spectrom pmid:18074333
Kachlicki P et al. Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. 2005 J Mass Spectrom pmid:15971291
Mitra T et al. Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions. 2012 J Mater Sci Mater Med pmid:22367159
Di Bella S et al. Salmonella enterica ssp. arizonae infection in a 43-year-old Italian man with hypoglobulinemia: a case report and review of the literature. 2011 J Med Case Rep pmid:21781321
Ruangpornvisuti V and Wanno B Molecular model for host–guest interaction of tetraamino-tert-butylthiacalix[4]arene and tetraamino-tert-butylcalix[4]arene receptors with carboxylate and dicarboxylate guests: an ONIOM study. 2007 J Mol Model pmid:16738872
Chojnacki H Proton transfer in some periodic molecular systems. 2007 J Mol Model pmid:17479303
Wang GW and Li FB Radical reactions of [60]fullerene mediated by manganese(III) acetate dihydrate. 2007 Apr-May J Nanosci Nanotechnol pmid:17450885
Loopuijt LD Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta. 2002 J Neural Transm pmid:12373561
Engeham S et al. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet. 2012 J Nutr Metab pmid:22536494
Gauniya A et al. Comparative bioavailability studies of citric acid and malonic acid based aspirin effervescent tablets. 2010 J Pharm Bioallied Sci pmid:21814444
Kim SC et al. Sensitive HPLC method for quantitation of paclitaxel (Genexol in biological samples with application to preclinical pharmacokinetics and biodistribution. 2005 J Pharm Biomed Anal pmid:16085137
Liu Z et al. The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer. 2012 J Pharm Biomed Anal pmid:22387101
de Spiegeleer B et al. Rapid determination of malonic acid by ion-pair reversed-phase high-performance liquid chromatography. 1986 J Pharm Biomed Anal pmid:16867607
Connors KA and Ifan A Chromogenic reactions of tertiary amines with polycarboxylic acids and acetic anhydride: carbon suboxide as the reactive species in the malonic acid reagent. 1987 J Pharm Sci pmid:3430350
Chaimbault C et al. Physicochemical and crystallographic evidence for polymorphism of the racemic ethyl (2-chloromethyl-2,3-dihydro-5H-oxazolo [3, 2-a]pyrimidin-5-one)-6-carboxylate. 2000 J Pharm Sci pmid:11015694
Pope FD et al. Studies of single aerosol particles containing malonic acid, glutaric acid, and their mixtures with sodium chloride. II. Liquid-state vapor pressures of the acids. 2010 J Phys Chem A pmid:20799753
Bermúdez E et al. Mechanism of the organocatalyzed decarboxylative Knoevenagel-Doebner reaction. A theoretical study. 2010 J Phys Chem A pmid:21105640
Ghorai S et al. Spectroscopic evidence of keto-enol tautomerism in deliquesced malonic acid particles. 2011 J Phys Chem A pmid:21480651
Beyer KD et al. Phase diagrams and water activities of aqueous ammonium salts of malonic acid. 2011 J Phys Chem A pmid:21428389
Cervellati R et al. Experimental and mechanistic investigation of an iodomalonic acid-based Briggs-Rauscher oscillator and its perturbations by resorcinol. 2010 J Phys Chem A pmid:21082849
Pope FD et al. Studies of single aerosol particles containing malonic acid, glutaric acid, and their mixtures with sodium chloride. I. Hygroscopic growth. 2010 J Phys Chem A pmid:20361768
Beyer KD et al. Temperature-dependent deliquescence relative humidities and water activities using humidity controlled thermogravimetric analysis with application to malonic acid. 2014 J Phys Chem A pmid:24628358
Preska Steinberg A et al. Target Turing patterns and growth dynamics in the chlorine dioxide-iodine-malonic acid reaction. 2014 J Phys Chem A pmid:24601764
Furrow SD and Aurentz DJ Reactions of iodomalonic acid, diiodomalonic acid, and other organics in the Briggs-Rauscher oscillating system. 2010 J Phys Chem A pmid:20121222
Zobrist B et al. Heterogeneous ice nucleation in aqueous solutions: the role of water activity. 2008 J Phys Chem A pmid:18363389
Kim HI and Beauchamp JL Cluster phase chemistry: collisions of vibrationally excited cationic dicarboxylic acid clusters with water molecules initiate dissociation of cluster components. 2007 J Phys Chem A pmid:17569511
Shen J et al. Ternary phase diagram for the Belousov-Zhabotinsky reaction-induced mechanical oscillation of intelligent PNIPAM colloids. 2007 J Phys Chem A pmid:17994710
Riipinen I et al. Adipic and malonic acid aqueous solutions: surface tensions and saturation vapor pressures. 2007 J Phys Chem A pmid:18044850
Kim HI et al. Cluster phase chemistry: gas-phase reactions of anionic sodium salts of dicarboxylic acid clusters with water molecules. 2006 J Phys Chem A pmid:16789762
Hegedüs L et al. Contribution to the chemistry of the Belousov-Zhabotinsky reaction. Products of the Ferriin-Bromomalonic acid and the Ferriin-Malonic acid reactions. 2006 J Phys Chem A pmid:17125298
Wang J et al. Coexistence of two bifurcation regimes in a closed ferroin-catalyzed Belousov-Zhabotinsky reaction. 2005 J Phys Chem A pmid:16833454
Kitahata H et al. Propagation of photosensitive chemical waves on the circular routes. 2005 J Phys Chem A pmid:16833846
Ojha B et al. 2-Alkylmalonic acid: amphiphilic chelator and a potent inhibitor of metalloenzyme. 2010 J Phys Chem B pmid:20669918
Hara Y and Yoshida R Self-oscillating polymer fueled by organic acid. 2008 J Phys Chem B pmid:18588335
Vanag VK et al. Cross-diffusion in a water-in-oil microemulsion loaded with malonic acid or ferroin. Taylor dispersion method for four-component systems. 2008 J Phys Chem B pmid:18610956
Hara Y et al. Generative force of self-oscillating gel. 2014 J Phys Chem B pmid:24524539
Nkuku CA and LeSuer RJ Electrochemistry in deep eutectic solvents. 2007 J Phys Chem B pmid:17973421
Himeno S et al. Simultaneous determination of phosphonate, phosphate, and diphosphate by capillary electrophoresis using in-capillary complexation with Mo(VI). 2007 J Sep Sci pmid:17566343
de Rijke E et al. Liquid chromatography coupled to nuclear magnetic resonance spectroscopy for the identification of isoflavone glucoside malonates in T. pratense L. leaves. 2004 J Sep Sci pmid:15495407
Batur M et al. Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. 2012 J Tradit Chin Med pmid:22594115
Garcia-Fernandez M et al. Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats. 2011 J Transl Med pmid:21798010
Vermeulen RC et al. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. 2010 J Transl Med pmid:20937116
Wu Q et al. LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans. 2004 J. Agric. Food Chem. pmid:15137811
Slimestad R et al. Onions: a source of unique dietary flavonoids. 2007 J. Agric. Food Chem. pmid:17997520
Onisko BC et al. Identification of fonofos metabolites in Latuca sativa, Beta vulgaris, and Triticum aestivum by packed capillary flow fast atom bombardment tandem mass spectrometry. 2002 J. Agric. Food Chem. pmid:11902934
Tsao R et al. Isoflavone profiles of red clovers and their distribution in different parts harvested at different growing stages. 2006 J. Agric. Food Chem. pmid:16881680
Cervellati R et al. Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. 2002 J. Agric. Food Chem. pmid:12475261
Thatcher GR et al. Novel nitrates as NO mimetics directed at Alzheimer's disease. 2004 J. Alzheimers Dis. pmid:15665418
Zipse H et al. Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. 2009 J. Am. Chem. Soc. pmid:19128178
Wolfenden R et al. Kinetic challenges facing oxalate, malonate, acetoacetate, and oxaloacetate decarboxylases. 2011 J. Am. Chem. Soc. pmid:21434608
Strieter ER et al. Cascade reactions during coronafacic acid biosynthesis: elongation, cyclization, and functionalization during Cfa7-catalyzed condensation. 2009 J. Am. Chem. Soc. pmid:19199623
Bonhomme C et al. 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. 2012 J. Am. Chem. Soc. pmid:22738329
Palaniappan N et al. cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme. 2008 J. Am. Chem. Soc. pmid:18714992
Martin CL et al. Total synthesis of (+/-)-actinophyllic acid. 2008 J. Am. Chem. Soc. pmid:18491907
GALAT A Ethyl formylaminomalonate; an intermediate in the synthesis of amino acids. 1947 J. Am. Chem. Soc. pmid:20292485
HAUSER CR et al. Proportion of ester anion and amide from esters and sodium amide; carbonation of esters; synthesis of malonic acid derivatives. 1946 J. Am. Chem. Soc. pmid:21008319
Comer E et al. Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. 2004 J. Am. Chem. Soc. pmid:15584744
Diener MD et al. (212)Pb@C(60) and its water-soluble derivatives: synthesis, stability, and suitability for radioimmunotherapy. 2007 J. Am. Chem. Soc. pmid:17394315
Nelson ME and Priestley ND Nonactin biosynthesis: the initial committed step is the condensation of acetate (malonate) and succinate. 2002 J. Am. Chem. Soc. pmid:11902879
Fortner KC and Shair MD Stereoelectronic effects dictate mechanistic dichotomy between Cu(II)-catalyzed and enzyme-catalyzed reactions of malonic acid half thioesters. 2007 J. Am. Chem. Soc. pmid:17263375
Pohl NL et al. Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. 2001 J. Am. Chem. Soc. pmid:11403625
Liang X et al. Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. 2002 J. Am. Chem. Soc. pmid:12149014
Karlsson T et al. A study of homonuclear dipolar recoupling pulse sequences in solid-state nuclear magnetic resonance. 2003 J. Am. Chem. Soc. pmid:12797814
Dickins RS et al. Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes. 2002 J. Am. Chem. Soc. pmid:12392417
Towler CS et al. Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'. 2004 J. Am. Chem. Soc. pmid:15479091
Chou HC et al. Multiple hydrogen bonds tuning guest/host excited-state proton transfer reaction: its application in molecular recognition. 2004 J. Am. Chem. Soc. pmid:14871093
Wenzel SC et al. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. 2006 J. Am. Chem. Soc. pmid:17076505
Trost BM and Lee CB Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part I. Asymmetric addition of malonate nucleophiles. 2001 J. Am. Chem. Soc. pmid:11457099
Sasamoto N et al. Pd(II)-catalyzed asymmetric addition of malonates to dihydroisoquinolines. 2006 J. Am. Chem. Soc. pmid:17061867
Nguyen Q et al. Rh2(II)-catalyzed intramolecular aliphatic C-H bond amination reactions using aryl azides as the N-atom source. 2012 J. Am. Chem. Soc. pmid:22519742
Zalups RK and Ahmad S Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. 2004 J. Am. Soc. Nephrol. pmid:15284288
Rhee EP et al. Metabolite profiling identifies markers of uremia. 2010 J. Am. Soc. Nephrol. pmid:20378825
Wolff NA et al. Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter. 2001 J. Am. Soc. Nephrol. pmid:11562399
Burckhardt BC et al. The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification. 2002 J. Am. Soc. Nephrol. pmid:12397032
Sasaki T et al. A novel macrolide antibiotic, notonesomycin A. 1986 J. Antibiot. pmid:3710911
Fukushima K et al. Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin. 1982 J. Antibiot. pmid:7161187
Solano-Serena F et al. Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. 2004 J. Appl. Microbiol. pmid:15281945
WOLFE JB et al. Malonate oxidation by dry cells and cell-free extracts of Pseudomonas fluorescens. 1955 J. Bacteriol. pmid:14367265
RANDLES CI and BIRKELAND JM The effects of malic and malonic acids on methylene blue reduction by bacteria. 1947 J. Bacteriol. pmid:20344612
Koo JH et al. The malonate decarboxylase operon of Acinetobacter calcoaceticus KCCM 40902 is regulated by malonate and the transcriptional repressor MdcY. 2000 J. Bacteriol. pmid:11053382
KOMINEK LA and HALVORSON HO MODE OF INHIBITION OF SPORULATION OF BACILLUS CEREUS BY ETHYL MALONATE AND ETHYL SUCCINATE. 1964 J. Bacteriol. pmid:14197898
GOLLAKOTA KG and HALVORSON HO BIOCHEMICAL CHANGES OCCURRING DURING SPORULATION OF BACILLUS CEREUS T. II. EFFECT OF ESTERS OF ORGANIC ACIDS ON SPORULATION. 1963 J. Bacteriol. pmid:14047234
Hori T and Okuyama H Variation of oleate/cis-vaccenate ratios and its regulation by substrates in hepatic tissues. 1987 J. Biochem. pmid:3654590
Mohri T et al. Differences of affinity and energetics of the active transport systems for amino acids in Chang liver cells. 1979 J. Biochem. pmid:34597
Iwakura M et al. Studies on regulatory functions of malic enzymes. VI. Purification and molecular properties of NADP-linked malic enzyme from Escherichia coli W. 1979 J. Biochem. pmid:36376
HOSOYA N and KAWADA N Effect of estradiol, nucleotides and bicarbonate on the metabolism of glucose and malonate. 1961 J. Biochem. pmid:13716089
Ishikura S et al. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. 2005 J. Biochem. pmid:15809331
Irikura D et al. Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. 2003 J. Biochem. pmid:12761195
Kim YS Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application. 2002 J. Biochem. Mol. Biol. pmid:12359084
Vujčić M et al. A comparative study of DNA binding and cell cycle phase perturbation by the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide N',N'(2) -bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. 2011 May-Jun J. Biochem. Mol. Toxicol. pmid:21671309
Jay D et al. Inhibition of membrane-bound succinate dehydrogenase by fluorescamine. 1993 J. Bioenerg. Biomembr. pmid:8144496