| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Abscess | D000038 | 13 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vasquez-Robinet C et al. | Physiological and molecular adaptations to drought in Andean potato genotypes. | 2008 | J. Exp. Bot. | pmid:18535297 |
| Merewitz EB et al. | Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation. | 2012 | J. Exp. Bot. | pmid:22131157 |
| Lahnsteiner F et al. | Sperm metabolism of the telost fishes Chalcalburnus chalcoides and Oncorhynchus mykiss and its relation to motility and viability. | 1999 | J. Exp. Zool. | pmid:10451423 |
| Chandra R et al. | Isolation and characterization of bacterial strains Paenibacillus sp. and Bacillus sp. for kraft lignin decolorization from pulp paper mill waste. | 2008 | J. Gen. Appl. Microbiol. | pmid:19164883 |
| Cox RB and Quayle JR | Synthesis and hydrolysis of malyl-coenzyme A by Pseudomonas AM1: an apparent malate synthase activity. | 1976 | J. Gen. Microbiol. | pmid:956773 |
| Janssen PH and Harfoot CG | Isolation of a Citrobacter species able to grow on malonate under strictly anaerobic conditions. | 1990 | J. Gen. Microbiol. | pmid:2384742 |
| Ferchichi M et al. | Production of methanethiol from methionine by Brevibacterium linens CNRZ 918. | 1985 | J. Gen. Microbiol. | pmid:3989511 |
| Zhang X et al. | Degradation of 17alpha-ethinylestradiol in aqueous solution by ozonation. | 2006 | J. Hazard. Mater. | pmid:16387433 |
| Bian W et al. | The intermediate products in the degradation of 4-chlorophenol by pulsed high voltage discharge in water. | 2011 | J. Hazard. Mater. | pmid:21802204 |
| Issabayeva G et al. | Continuous adsorption of lead ions in a column packed with palm shell activated carbon. | 2008 | J. Hazard. Mater. | pmid:18179867 |
| Cui YH et al. | Comparison of various organic compounds destruction on rare earths doped Ti/Sb-SnO2 electrodes. | 2012 | J. Hazard. Mater. | pmid:23022412 |
| Gao J et al. | Determination of 1-naphthylamine by using oscillating chemical reaction. | 2007 | J. Hazard. Mater. | pmid:17097225 |
| Fleck J et al. | Intrastriatal malonate administration induces convulsive behaviour in rats. | 2004 | J. Inherit. Metab. Dis. | pmid:15159652 |
| Salomons GS et al. | Clinical, enzymatic and molecular characterization of nine new patients with malonyl-coenzyme A decarboxylase deficiency. | 2007 | J. Inherit. Metab. Dis. | pmid:17186413 |
| Matalon R et al. | Malonic aciduria and cardiomyopathy. | 1993 | J. Inherit. Metab. Dis. | pmid:7609455 |
| Buyukgebiz B et al. | Fatal neonatal malonic aciduria. | 1998 | J. Inherit. Metab. Dis. | pmid:9501274 |
| Gregg AR et al. | Combined malonic and methylmalonic aciduria with normal malonyl-coenzyme A decarboxylase activity: a case supporting multiple aetiologies. | 1998 | J. Inherit. Metab. Dis. | pmid:9700595 |
| Brown GK et al. | Malonyl coenzyme A decarboxylase deficiency. | 1984 | J. Inherit. Metab. Dis. | pmid:6145813 |
| Wanders RJ et al. | The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. | 2010 | J. Inherit. Metab. Dis. | pmid:20490924 |
| Mirandola SR et al. | Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake. | 2008 | J. Inherit. Metab. Dis. | pmid:18213522 |
| O'Brien DP et al. | Malonic aciduria in Maltese dogs: normal methylmalonic acid concentrations and malonyl-CoA decarboxylase activity in fibroblasts. | 1999 | J. Inherit. Metab. Dis. | pmid:10604140 |
| Hanif M et al. | From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands. | 2011 | J. Inorg. Biochem. | pmid:21194622 |
| Cutbush SD et al. | The antitumor complex ethylenediamine platinum (II) malonate: x-ray structure analysis, and studies of its stability in solution. | 1983 | J. Inorg. Biochem. | pmid:6875536 |
| Creaven BS et al. | Synthesis, characterisation and antimicrobial activity of copper(II) and manganese(II) complexes of coumarin-6,7-dioxyacetic acid (cdoaH2) and 4-methylcoumarin-6,7-dioxyacetic acid (4-MecdoaH2): X-ray crystal structures of [Cu(cdoa)(phen)2].8.8H(2)O and [Cu(4-Mecdoa)(phen)2].13H2O (phen=1,10-phenanthroline). | 2007 | J. Inorg. Biochem. | pmid:17555821 |
| Eshkourfu R et al. | Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. | 2011 | J. Inorg. Biochem. | pmid:21722616 |
| Ainscough EW et al. | Spectroscopic studies on copper (II) complexes of human lactoferrin. | 1983 | J. Inorg. Biochem. | pmid:6304246 |
| Alsaadi BM et al. | A pmr study of the effects of pH and anion and metal ion binding of the histidyl residues of ovotransferrin. | 1981 | J. Inorg. Biochem. | pmid:7276935 |
| ROSTENBERG A and GONZALEZ EL | The inhibition of perspiration by means of the topical application of malonic acid salts. | 1957 | J. Invest. Dermatol. | pmid:13491887 |
| Hegardt FG et al. | Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631216 |
| Honda A et al. | Highly sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:19403942 |
| Gao J et al. | Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. | 1999 | J. Lipid Res. | pmid:9869665 |
| Elliott DW et al. | De-Pake-ing transform analysis of fully deuterated malonic acid. | 2009 | J. Magn. Reson. | pmid:19608443 |
| Kristensen JH et al. | Separation of (2)H MAS NMR spectra by two-dimensional spectroscopy. | 1999 | J. Magn. Reson. | pmid:10423369 |
| Pandey MK et al. | Composite-180° pulse-based symmetry sequences to recouple proton chemical shift anisotropy tensors under ultrafast MAS solid-state NMR spectroscopy. | 2015 | J. Magn. Reson. | pmid:25497846 |
| Kang J et al. | Electronic g-factor measurement from ENDOR-induced EPR patterns: malonic acid and guanine hydrochloride dihydrate. | 2003 | J. Magn. Reson. | pmid:14568523 |
| Lee KH et al. | Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents. | 1981 | J. Med. Chem. | pmid:7328595 |
| Ye B et al. | L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. | 1995 | J. Med. Chem. | pmid:7473554 |
| Kraker AJ et al. | Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups. | 1992 | J. Med. Chem. | pmid:1335074 |
| Ward RA et al. | Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. | 2012 | J. Med. Chem. | pmid:22417091 |
| Graf von Roedern E et al. | Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). | 1998 | J. Med. Chem. | pmid:9464365 |
| Wilhelm A et al. | 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept. | 2012 | J. Med. Chem. | pmid:23106316 |
| Hoffman HE et al. | Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. | 2009 | J. Med. Chem. | pmid:19791805 |
| Burke TR et al. | 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. | 1996 | J. Med. Chem. | pmid:8676336 |
| Abraham DJ et al. | Design, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids. | 1984 | J. Med. Chem. | pmid:6747995 |
| Lange G et al. | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. | 2003 | J. Med. Chem. | pmid:14613321 |
| Alfares A et al. | Combined malonic and methylmalonic aciduria: exome sequencing reveals mutations in the ACSF3 gene in patients with a non-classic phenotype. | 2011 | J. Med. Genet. | pmid:21785126 |
| Park SR et al. | Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. | 2011 | J. Microbiol. Biotechnol. | pmid:22127124 |
| Stieglitz K et al. | Monitoring the transition from the T to the R state in E.coli aspartate transcarbamoylase by X-ray crystallography: crystal structures of the E50A mutant enzyme in four distinct allosteric states. | 2004 | J. Mol. Biol. | pmid:15288791 |
| Zara V et al. | Biogenesis of the dicarboxylate carrier (DIC): translocation across the mitochondrial outer membrane and subsequent release from the TOM channel are membrane potential-independent. | 2001 | J. Mol. Biol. | pmid:11502005 |
| Zunszain PA et al. | Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha. | 2008 | J. Mol. Biol. | pmid:18602119 |
| Chandrasekar S et al. | Structure of the chloroplast signal recognition particle (SRP) receptor: domain arrangement modulates SRP-receptor interaction. | 2008 | J. Mol. Biol. | pmid:18035371 |
| Larson SB et al. | Crystallographic structure of the T=1 particle of brome mosaic virus. | 2005 | J. Mol. Biol. | pmid:15713465 |
| Harris P | The interpretation of the distribution of radioactivity between carboxyl and alkyl carbon in fatty acids, following exposure to 14C-labelled acetate or malonate. | 1979 | J. Mol. Cell. Cardiol. | pmid:522139 |
| Borutaite V et al. | Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia. | 1996 | J. Mol. Cell. Cardiol. | pmid:8930814 |
| Lovell TM et al. | Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides. | 2007 | J. Mol. Endocrinol. | pmid:17766644 |
| Tang GL et al. | Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. | 2006 | J. Nat. Prod. | pmid:16562841 |
| Koeppen AH et al. | Lipid labeling after intracerebral injection of radioactive malonic acid. | 1980 | J. Neurochem. | pmid:7411143 |
| Maciel EN et al. | Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition. | 2004 | J. Neurochem. | pmid:15312158 |
| Greene JG and Greenamyre JT | Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. | 1995 | J. Neurochem. | pmid:7536810 |
| Maragos WF and Silverstein FS | Inhibition of nitric oxide synthase activity attenuates striatal malonate lesions in rats. | 1995 | J. Neurochem. | pmid:7536812 |
| Mitzen EJ and Koeppen AH | Malonate, malonyl-coenzyme A, and acetyl-coenzyme A in developing rat brain. | 1984 | J. Neurochem. | pmid:6429279 |
| Zeevalk GD et al. | Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures. | 1997 | J. Neurochem. | pmid:8978755 |
| Connop BP et al. | Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole. | 1997 | J. Neurochem. | pmid:9048766 |
| Ferger B et al. | Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation. | 1999 | J. Neurochem. | pmid:10461928 |
| Xia XG et al. | Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation. | 2001 | J. Neurochem. | pmid:11595758 |
| Hansson O et al. | Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length. | 2001 | J. Neurochem. | pmid:11520890 |
| Demougeot C et al. | N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. | 2001 | J. Neurochem. | pmid:11299303 |
| Nixdorf WL et al. | Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate. | 2001 | J. Neurochem. | pmid:11299327 |
| Ehrhart J and Zeevalk GD | Hydrogen peroxide removal and glutathione mixed disulfide formation during metabolic inhibition in mesencephalic cultures. | 2001 | J. Neurochem. | pmid:11413233 |
| Koeppen AH and Riley KM | Effect of free malonate on the utilization of glutamate by rat brain mitochondria. | 1987 | J. Neurochem. | pmid:2881982 |
| Rocha MA et al. | Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions. | 2008 | J. Neurochem. | pmid:18363831 |
| Beal MF et al. | Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. | 1993 | J. Neurochem. | pmid:7689641 |
| Klivenyi P et al. | Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. | 2004 | J. Neurochem. | pmid:15009635 |
| Ehrhart J and Zeevalk GD | Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures. | 2003 | J. Neurochem. | pmid:12950457 |
| Greene JG et al. | Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. | 1993 | J. Neurochem. | pmid:8360680 |
| Vayer P et al. | Conversion of gamma-hydroxybutyrate to gamma-aminobutyrate in vitro. | 1985 | J. Neurochem. | pmid:2863327 |
| Pang Z et al. | Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. | 1996 | J. Neurochem. | pmid:8592116 |
| Greene JG and Greenamyre JT | Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. | 1996 | J. Neurochem. | pmid:8592134 |
| Schulz JB et al. | Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. | 1996 | J. Neurochem. | pmid:8667023 |
| Moy LY et al. | Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures. | 2000 | J. Neurochem. | pmid:10737624 |
| Hassel B et al. | Cerebral dicarboxylate transport and metabolism studied with isotopically labelled fumarate, malate and malonate. | 2002 | J. Neurochem. | pmid:12124442 |
| Andreassen OA et al. | Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant. | 2000 | J. Neurochem. | pmid:10899963 |
| Kaal EC et al. | Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis. | 2000 | J. Neurochem. | pmid:10693948 |
| Alfinito PD et al. | Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. | 2003 | J. Neurosci. | pmid:14645494 |
| Huang QY et al. | Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. | 2006 | J. Neurosci. | pmid:17079665 |
| Klivenyi P et al. | Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. | 2000 | J. Neurosci. | pmid:10627575 |
| Matthews RT et al. | Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. | 1998 | J. Neurosci. | pmid:9412496 |
| Huber R et al. | Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices. | 2004 | J. Neurosci. Res. | pmid:14743458 |
| Stokes AH et al. | Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711. | 2001 | J. Neurosci. Res. | pmid:11276050 |
| Mattson MP et al. | Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. | 1995 | J. Neurosci. Res. | pmid:8583504 |
| Zhang D et al. | Synthesis of indenes by the transition metal-mediated carboannulation of alkynes. | 2007 | J. Org. Chem. | pmid:17194107 |
| Mao Z et al. | Water-compatible iminium activation: highly enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated enones. | 2010 | J. Org. Chem. | pmid:20936828 |
| Volonterio A and Zanda M | Multicomponent, one-pot sequential synthesis of 1,3,5- and 1,3,5,5-substituted barbiturates. | 2008 | J. Org. Chem. | pmid:18754580 |
| Orellana A et al. | A Diels-Alder-based total synthesis of (-)-kainic acid. | 2012 | J. Org. Chem. | pmid:22551444 |
| Duan S et al. | Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters. | 2009 | J. Org. Chem. | pmid:19518152 |
| Kokubo K et al. | Synthesis and regiochemistry of [60]fullerenyl 2-methylmalonate bisadducts and their facile electron-accepting properties. | 2010 | J. Org. Chem. | pmid:20524640 |
| Blaquiere N et al. | Decarboxylative ketone aldol reactions: development and mechanistic evaluation under metal-free conditions. | 2009 | J. Org. Chem. | pmid:20560569 |
| Fan R et al. | Tandem Knoevenagel-Michael addition of aryl sulfonimines with diethyl malonate for synthesis of arylidene dimalonates. | 2007 | J. Org. Chem. | pmid:17585824 |
| Yi C et al. | An efficient and facile synthesis of highly substituted 2,6-dicyanoanilines. | 2008 | J. Org. Chem. | pmid:18341285 |
| Malik G et al. | Aziridines from intramolecular alkene aziridination of sulfamates: reactivity toward carbon nucleophiles. application to the synthesis of spisulosine and its fluoro analogue. | 2011 | J. Org. Chem. | pmid:21812488 |