| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Abscess | D000038 | 13 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arihara K et al. | Contribution of the glycolytic pathway to enzymatic metmyoglobin reduction in myocytes. | 1996 | Biochem. Mol. Biol. Int. | pmid:8850528 |
| Klein BY et al. | Opposing effects on mitochondrial membrane potential by malonate and levamisole, whose effect on cell-mediated mineralization is antagonistic. | 1996 | J. Cell. Biochem. | pmid:8825423 |
| Connop BP et al. | Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase. | 1996 | Neuropharmacology | pmid:8793908 |
| Bazzett TJ et al. | Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. | 1996 | Brain Res. | pmid:8773793 |
| Albers DS et al. | Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP. | 1996 | Brain Res. | pmid:8773791 |
| Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
| Murrin SF and Nolan RA | Ultrastructural localization of succinate dehydrogenase in a self-parasitic isolate of Saprolegnia megasperma. | 1977 | Can. J. Microbiol. | pmid:871965 |
| Bekina RM and Lebedeva AF | [Studies of oxygen uptake (Mehler reactions) in chloroplasts in the presence of silico-molybdic acid]. | 1977 | Biokhimiia | pmid:870090 |
| Schulz JB et al. | Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. | 1996 | Neuroscience | pmid:8684608 |
| Burke TR et al. | 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. | 1996 | J. Med. Chem. | pmid:8676336 |
| Schulz JB et al. | Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. | 1996 | J. Neurochem. | pmid:8667023 |
| Greene JG and Greenamyre JT | Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. | 1996 | J. Neurochem. | pmid:8592134 |
| Pang Z et al. | Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. | 1996 | J. Neurochem. | pmid:8592116 |
| Spetale MR et al. | The effect of organophosphorus compounds on respiration by rat liver mitochondria. | 1977 | Farmaco Sci | pmid:858381 |
| Mattson MP et al. | Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. | 1995 | J. Neurosci. Res. | pmid:8583504 |
| Zeevalk GD et al. | Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. | 1995 | J. Pharmacol. Exp. Ther. | pmid:8531072 |
| Demchuk ML et al. | [Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]. | 1993 Mar-Apr | Vopr. Med. Khim. | pmid:8511880 |
| Brand MD et al. | Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. | 1993 | Biochem. J. | pmid:8489502 |
| Cox DA and Matlib MA | A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. | 1993 | J. Biol. Chem. | pmid:8419373 |
| Taylor RW et al. | Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. | 1993 | Biochim. Biophys. Acta | pmid:8391327 |
| Greene JG et al. | Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. | 1993 | J. Neurochem. | pmid:8360680 |
| Perez J and Jeffries TW | Role of organic acid chelators in manganese regulation of lignin degradation by Phanerochaete chrysosporium. | 1993 | Appl. Biochem. Biotechnol. | pmid:8323262 |
| Davydov VV and FreÄdin MI | [The effect of malonic acid on the rate of fibroblast proliferation in culture]. | 1993 | Tsitologiia | pmid:8322417 |
| Valla A et al. | [Descriptive modeling of the chemical structure-biological activity relations of a group of malonic polyethylenic acids as shown by different pharmacotoxicologic tests]. | 1993 | Pharmazie | pmid:8321881 |
| Windsor DP and White IG | Assessment of ram sperm mitochondrial function by quantitative determination of sperm rhodamine 123 accumulation. | 1993 | Mol. Reprod. Dev. | pmid:8286118 |
| Muralikrishna C and Renganathan V | Peroxidase-catalyzed desulfonation of 3,5-dimethyl-4-hydroxy and 3,5-dimethyl-4-aminobenzenesulfonic acids. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267618 |
| Karuri AR et al. | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. | 1993 | Br. J. Cancer | pmid:8260358 |
| Parmentier GG et al. | Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases. | 1993 | Steroids | pmid:8212084 |
| Medeiros MH et al. | Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. | 1994 | Arch. Biochem. Biophys. | pmid:8161206 |
| Jay D et al. | Inhibition of membrane-bound succinate dehydrogenase by fluorescamine. | 1993 | J. Bioenerg. Biomembr. | pmid:8144496 |
| Lançar-Benba J et al. | Purification of the rat-liver mitochondrial dicarboxylate carrier by affinity chromatography on immobilized malate dehydrogenase. | 1994 | Biochim. Biophys. Acta | pmid:8142418 |
| Nikiforov AA and Ostretsova IB | Stimulation of weak organic acid uptake in rat renal tubules by cadmium and nystatin. | 1994 | Biochem. Pharmacol. | pmid:8135857 |
| Tassani V et al. | Anaplerotic effect of propionyl carnitine in rat heart mitochondria. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8135845 |
| Beattie DS et al. | Oxidation of NADH by a rotenone and antimycin-sensitive pathway in the mitochondrion of procyclic Trypanosoma brucei brucei. | 1994 | Mol. Biochem. Parasitol. | pmid:8078526 |
| Henshaw R et al. | Malonate produces striatal lesions by indirect NMDA receptor activation. | 1994 | Brain Res. | pmid:8069700 |
| Boland NI et al. | Characterization of follicular energy metabolism. | 1994 | Hum. Reprod. | pmid:8046010 |
| Reiss U and Rothstein M | Age-related changes in isocitrate lyase from the free living nematode, Turbatrix aceti. | 1975 | J. Biol. Chem. | pmid:803500 |
| Beal MF et al. | Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. | 1994 | Ann. Neurol. | pmid:7998775 |
| Ray S et al. | Inhibition of electron flow through complex I of the mitochondrial respiratory chain of Ehrlich ascites carcinoma cells by methylglyoxal. | 1994 | Biochem. J. | pmid:7945267 |
| Kim YS and Kim EJ | A plasmid responsible for malonate assimilation in Pseudomonas fluorescens. | 1994 | Plasmid | pmid:7846146 |
| Brand MD et al. | The sum of flux control coefficients in the electron-transport chain of mitochondria. | 1994 | Eur. J. Biochem. | pmid:7813471 |
| Oldendorf WH et al. | Transient blood-brain barrier passage of polar compounds at low pH. | 1994 | Am. J. Physiol. | pmid:7810722 |
| Nieva-Gomez D and Konisky J | Membrane changes in Escherichia coli induced by colicin Ia and agents known to disrupt energy transduction. | 1976 | Biochemistry | pmid:779829 |
| Kirschner PB et al. | Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. | 1995 | J. Cereb. Blood Flow Metab. | pmid:7790410 |
| Klein BY et al. | Analysis of cell-mediated mineralization in culture of bone-derived embryonic cells with neurofibromatosis. | 1995 | J. Cell. Biochem. | pmid:7768987 |
| Ermayanti TM et al. | Stimulation of synthesis and release of swainosonine from transformed roots of Swainsona galegifolia. | 1994 | Phytochemistry | pmid:7764877 |
| Dehning I and Schink B | Anaerobic degradation of malonate via malonyl-CoA by Sporomusa malonica, Klebsiella oxytoca, and Rhodobacter capsulatus. | 1994 | Antonie Van Leeuwenhoek | pmid:7710283 |
| Schuster H et al. | Substrate and product binding sites of yeast fatty acid synthase. Stoichiometry and binding kinetics of wild-type and in vitro mutated enzymes. | 1995 | Eur. J. Biochem. | pmid:7705357 |
| Davydov VV et al. | [Effect of malonate on various aspects of hepatic metabolism]. | 1994 Oct-Dec | Patol Fiziol Eksp Ter | pmid:7700705 |
| Byun HS and Kim YS | Assays for malonate decarboxylase. | 1994 | Anal. Biochem. | pmid:7695096 |