Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
FAWAZ EN and FAWAZ G Inhibition of glycolysis in rat skeletal muscle by malonate. 1962 Biochem. J. pmid:13891870
BU'LOCK JD et al. Malonate as a biosynthetic intermediate in Penicillium urticae. 1962 J. Biol. Chem. pmid:13874181
pmid:13843244
pmid:13842636
pmid:13741238
pmid:13716584
HOSOYA N and KAWADA N Effect of estradiol, nucleotides and bicarbonate on the metabolism of glucose and malonate. 1961 J. Biochem. pmid:13716089
Nikiforov AA and Ostretsova IB Effects of metabolic substrates and inhibitors on weak organic anion transport in rat renal proximal tubules. 1997 May-Jun Ross Fiziol Zh Im I M Sechenova pmid:13677672
VICKERY HB The metabolism of the organic acids of tobacco leaves. XVI. Effect of culture of excised leaves in solutions of malonate. 1959 J. Biol. Chem. pmid:13654379
pmid:13572052
pmid:13534680
ROSTENBERG A and GONZALEZ EL The inhibition of perspiration by means of the topical application of malonic acid salts. 1957 J. Invest. Dermatol. pmid:13491887
NAKADA HI et al. Degradation of malonic acid by rat tissues. 1957 J. Biol. Chem. pmid:13428746
VICKERY HB and PALMER JK The metabolism of the organic acids of tobacco leaves. XII. Effect of culture of excised leaves in solutions of malonate at pH 4 to pH 7. 1957 J. Biol. Chem. pmid:13416266
pmid:13358057
Kraker AJ et al. Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups. 1992 J. Med. Chem. pmid:1335074
MOOKERJEA S and SADHU DP Metabolic depression by arsenite and malonate and cholesterologenesis. 1955 Arch. Biochem. Biophys. pmid:13259694
WOLFE JB and RITTENBERG SC Malonate decarboxylation by Pseudomonas fluorescens. III. The rôle of acetyl coenzyme A. 1954 J. Biol. Chem. pmid:13192143
WOLFE JB et al. Malonate decarboxylation by Pseudomonas fluorescens. II. Magnesium dependency and trapping of active intermediates. 1954 J. Biol. Chem. pmid:13192142
WOLFE JB et al. Malonate decarboxylation by Pseudomonas fluorescens. I. Observations with dry cells and cell-free preparations. 1954 J. Biol. Chem. pmid:13192141
Shigematsu T et al. Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge. 2003 Int. J. Syst. Evol. Microbiol. pmid:13130036
pmid:13076217
THORN MB Inhibition by malonate of succinic dehydrogenase in heart-muscle preparations. 1953 Biochem. J. pmid:13058948
Davydov VV et al. [The antihypoxic action of malonic acid]. 1992 Nov-Dec Eksp Klin Farmakol pmid:1305881
BUSCH H and POTTER VR Studies on tissue metabolism by means of in vivo metabolic blocking technics. II. Metabolism of acetate-1-C14 in malonate-treated rats. 1953 Cancer Res. pmid:13042804
THORN MB Malonate inhibition of succinic dehydrogenase. 1953 Biochem. J. pmid:13037647
BUSCH H and POTTER VR Succinate accumulation in vivo following injection of malonate. 1952 J. Biol. Chem. pmid:12999717
pmid:12999622
pmid:12999621
BUSCH H and POTTER VR Studies on tissue metabolism by means of in vivo metabolic blocking technics. I. A survey of changes induced by malonate in tissues of tumor-bearing rats. 1952 Cancer Res. pmid:12978997
Kölker S et al. Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain. 2003 J. Biol. Chem. pmid:12972416
pmid:12971787
pmid:12971763
Ehrhart J and Zeevalk GD Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures. 2003 J. Neurochem. pmid:12950457
pmid:12950184
Furin A et al. Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates. 2003 Jul-Aug Eur J Med Chem pmid:12932905
Shefer TV et al. Effect of sodium succinate on gas exchange in rats with barbiturate-induced coma. 2003 Bull. Exp. Biol. Med. pmid:12910308
pmid:12904032
pmid:12898627
pmid:12895096
Newell DR et al. Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. 2003 Br. J. Cancer pmid:12888809
Renné P et al. The Arabidopsis mutant dct is deficient in the plastidic glutamate/malate translocator DiT2. 2003 Plant J. pmid:12887583
pmid:12880697
pmid:12876372
Wang SC et al. Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: consequences of and evidence for a hydration reaction. 2003 Biochemistry pmid:12873137
pmid:12862486
Lastres-Becker I et al. Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. 2003 Neuroreport pmid:12858038
Liu Z et al. A facile solid phase synthesis of tetramic acid. 2003 Bioorg. Med. Chem. Lett. pmid:12852953
Ismail W et al. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. 2003 Eur. J. Biochem. pmid:12846838
pmid:12830899
Miyasawa H et al. Xylitol inhibition of anaerobic acid production by Streptococcus mutans at various pH levels. 2003 Oral Microbiol. Immunol. pmid:12823796
Karlsson T et al. A study of homonuclear dipolar recoupling pulse sequences in solid-state nuclear magnetic resonance. 2003 J. Am. Chem. Soc. pmid:12797814
pmid:12777781
pmid:12774021
Irikura D et al. Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. 2003 J. Biochem. pmid:12761195
Botta M et al. Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution: an NMR relaxometric study. 2003 Chemistry pmid:12740859
Organ MG et al. On the regiochemistry of nucleophilic attack on 2-halo pi-allyl complexes. 4. The effect of silver acetate and nucleophile concentrations in competitive nucleophilic attack with malonate and phenoxide nucleophiles. 2003 J. Org. Chem. pmid:12737572
pmid:12733875
pmid:12720463
pmid:12720458
Takenaka T et al. Fatty acids as an energy source for the operation of axoplasmic transport. 2003 Brain Res. pmid:12711076
McCarter JP et al. Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. 2003 Genome Biol. pmid:12702207
pmid:12697169
pmid:12693921
pmid:12691745
pmid:12691577
Konar S et al. Syntheses of two new 1D and 3D networks of Cu(II) and Co(II) using malonate and urotropine as bridging ligands: crystal structures and magnetic studies. 2003 Inorg Chem pmid:12691560
pmid:12688972
pmid:12688908
Porras SP et al. Capillary electrophoresis of methyl-substituted phenols in acetonitrile. 2003 J Chromatogr A pmid:12685581
pmid:12683722
Gellerman JL et al. Synthesis of anacardic acids in seeds of Ginkgo biloba. 1976 Biochim. Biophys. Acta pmid:1268241
pmid:12682389
Creighton C et al. Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas. 2003 FEBS Lett. pmid:12681502
Taha A Spectral, electrochemical and molecular orbital studies on solvatochromic mixed ligand copper(II) complexes of malonate and diamine derivatives. 2003 Spectrochim Acta A Mol Biomol Spectrosc pmid:12659906
Koshkin V et al. Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. 2003 J. Biol. Chem. pmid:12642585
pmid:12617633
pmid:12604081
Ramana ChV et al. Photobiodegradation of pyridine by Rhodopseudomonas palustris JA1. 2002 Indian J. Exp. Biol. pmid:12597034
Coyle B et al. Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. 2003 Biometals pmid:12572690
pmid:12562184
pmid:12561122
Zhang L and Sheng C [Separation of dicarboxylic acid by thin-layer chromatography]. 1999 Se Pu pmid:12552870
Ledesma A et al. The mitochondrial uncoupling proteins. 2002 Genome Biol. pmid:12537581
Zhang Y et al. A novel alpha-helix-liked metallohelicate series and their structural adjustments for the isomorphous substitution. 2000 Inorg Chem pmid:12526493
Ruiz-Pérez C et al. Ferromagnetism in malonato-bridged copper(II) complexes. Synthesis, crystal structures, and magnetic properties of [[Cu(H2O)3][Cu(mal)2(H2O)]]n and [[Cu(H2O)4]2[Cu(mal)2(H2O)]][Cu(mal)2(H2O)2][[Cu(H2O)4][Cu(mal)2(H2O)2][(H2mal = malonic acid). 2000 Inorg Chem pmid:12526437
Armentero MT et al. Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the rat. 2002 Exp. Neurol. pmid:12504889
Sweet DH et al. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. 2003 Am. J. Physiol. Renal Physiol. pmid:12488248
Basak K and Majumdar SK Effect of some inhibitors on kanamycin formation by Streptomyces kanamyceticus. 1976 Folia Microbiol. (Praha) pmid:1248783
Colsenet R et al. A straightforward detection of deprotonated conformers of malonic acid by solid-state 13C NMR spectroscopy. 2002 Angew. Chem. Int. Ed. Engl. pmid:12481345
Cervellati R et al. Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. 2002 J. Agric. Food Chem. pmid:12475261
Petersén A et al. Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice. 2002 Neurobiol. Dis. pmid:12460553
Saraswathi NT and Vijayan M X-ray studies on crystalline complexes involving amino acids and peptides. XL. Conformational variability, recurring and new features of aggregation, and effect of chirality in the malonic acid complexes of DL- and L-arginine. 2002 Acta Crystallogr., B pmid:12456986
Pomytkin IA and Kolesova OE Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases. 2002 Bull. Exp. Biol. Med. pmid:12447467
An JH et al. Symbiotic effects of deltamatB Rhizobium leguminosarum bv. trifolii mutant on clovers. 2002 Mol. Cells pmid:12442899
pmid:12434365
Burckhardt BC et al. The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification. 2002 J. Am. Soc. Nephrol. pmid:12397032
Dickins RS et al. Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes. 2002 J. Am. Chem. Soc. pmid:12392417
pmid:12392401
Lash LH et al. Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. 2002 J. Pharmacol. Exp. Ther. pmid:12388626