| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Abscess | D000038 | 13 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Karakikes I et al. | Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. | 2009 | PLoS ONE | pmid:19649297 |
| Brown AK et al. | Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases. | 2009 | PLoS ONE | pmid:19609444 |
| Pistollato F et al. | Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells. | 2009 | PLoS ONE | pmid:19587783 |
| Shi D et al. | A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. | 2011 | PLoS ONE | pmid:22174908 |
| Schiff M et al. | Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice. | 2011 | PLoS ONE | pmid:22174907 |
| Hench J et al. | A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans. | 2011 | PLoS ONE | pmid:22162770 |
| Paul D et al. | Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions. | 2011 | PLoS ONE | pmid:21386900 |
| Lallous N et al. | The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers. | 2011 | PLoS ONE | pmid:22096602 |
| Oberto J et al. | The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction. | 2009 | PLoS ONE | pmid:19194530 |
| Tiziani S et al. | Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines. | 2009 | PLoS ONE | pmid:19158949 |
| Seifert EL et al. | Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria. | 2010 | PLoS ONE | pmid:20352092 |
| Finley LW et al. | Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. | 2011 | PLoS ONE | pmid:21858060 |
| Jeong YS et al. | Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. | 2011 | PLoS ONE | pmid:21811631 |
| Rogers GW et al. | High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. | 2011 | PLoS ONE | pmid:21799747 |
| Bauwens M et al. | Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers. | 2012 | PLoS ONE | pmid:22719886 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Chojkier M et al. | Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. | 2012 | PLoS ONE | pmid:22412837 |
| Eloe EA et al. | Going deeper: metagenome of a hadopelagic microbial community. | 2011 | PLoS ONE | pmid:21629664 |
| Hashimoto T et al. | Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles. | 2008 | PLoS ONE | pmid:18698340 |
| Lin H et al. | The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. | 2011 | PLoS ONE | pmid:21552483 |
| Buck M | Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures. | 2008 | PLoS ONE | pmid:18628977 |
| GarcÃa-Torres I et al. | Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes. | 2011 | PLoS ONE | pmid:21533154 |
| Matar-Merheb R et al. | Structuring detergents for extracting and stabilizing functional membrane proteins. | 2011 | PLoS ONE | pmid:21483854 |
| Minato Y et al. | Malonate inhibits virulence gene expression in Vibrio cholerae. | 2013 | PLoS ONE | pmid:23675480 |
| Gallo M et al. | MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion. | 2011 | PLoS ONE | pmid:21448454 |
| Damrauer SM et al. | A20 modulates lipid metabolism and energy production to promote liver regeneration. | 2011 | PLoS ONE | pmid:21437236 |
| Rakhimova E et al. | Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection. | 2008 | PLoS ONE | pmid:18301762 |
| Rudrappa T et al. | Cyanogenic pseudomonads influence multitrophic interactions in the rhizosphere. | 2008 | PLoS ONE | pmid:18446201 |
| Thomas B et al. | Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. | 2011 | PLoS ONE | pmid:21304957 |
| Qi M et al. | Genome sequence analyses of Pseudomonas savastanoi pv. glycinea and subtractive hybridization-based comparative genomics with nine pseudomonads. | 2011 | PLoS ONE | pmid:21304594 |
| Yang L et al. | Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. | 2009 | PLoS ONE | pmid:19484125 |
| Kubicek J et al. | Controlled in meso phase crystallization--a method for the structural investigation of membrane proteins. | 2012 | PLoS ONE | pmid:22536388 |
| Brisse S et al. | Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. | 2009 | PLoS ONE | pmid:19319196 |
| Kil DY et al. | Age and diet affect gene expression profiles in canine liver tissue. | 2010 | PLoS ONE | pmid:20967283 |
| Shi T et al. | cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. | 2010 | PLoS ONE | pmid:20957031 |
| Mailloux RJ et al. | The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. | 2007 | PLoS ONE | pmid:17668068 |
| Wise JK et al. | Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration. | 2010 | PLoS ONE | pmid:20957030 |
| Pradhan RK et al. | Characterization of membrane potential dependency of mitochondrial Ca2+ uptake by an improved biophysical model of mitochondrial Ca2+ uniporter. | 2010 | PLoS ONE | pmid:20949039 |
| Wu L et al. | Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil. | 2011 | PLoS ONE | pmid:21655235 |
| Hagopian K et al. | Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. | 2010 | PLoS ONE | pmid:20856881 |
| Mochel F et al. | Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression. | 2007 | PLoS ONE | pmid:17653274 |
| Sripadi P et al. | Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry. | 2010 | PLoS ONE | pmid:20830293 |
| Hanin A et al. | Screening of in vivo activated genes in Enterococcus faecalis during insect and mouse infections and growth in urine. | 2010 | PLoS ONE | pmid:20686694 |
| Psychogios N et al. | The human serum metabolome. | 2011 | PLoS ONE | pmid:21359215 |
| Granjon T et al. | Structure-function relations in oxaloacetate decarboxylase complex. Fluorescence and infrared approaches to monitor oxomalonate and Na(+) binding effect. | 2010 | PLoS ONE | pmid:20543879 |
| Marreddy RK et al. | Amino acid accumulation limits the overexpression of proteins in Lactococcus lactis. | 2010 | PLoS ONE | pmid:20436673 |
| Shimshek DR et al. | The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. | 2010 | PLoS ONE | pmid:20368804 |
| Lim S et al. | D-β-hydroxybutyrate is protective in mouse models of Huntington's disease. | 2011 | PLoS ONE | pmid:21931779 |
| Gonzalvez F et al. | Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin. | 2010 | PLoS ONE | pmid:20179769 |
| Chanumolu SK et al. | UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. | 2012 | PLoS ONE | pmid:22431985 |
| Zhao JS et al. | Shewanella spp. genomic evolution for a cold marine lifestyle and in-situ explosive biodegradation. | 2010 | PLoS ONE | pmid:20174598 |
| Smejkalová H et al. | Methanol assimilation in Methylobacterium extorquens AM1: demonstration of all enzymes and their regulation. | 2010 | PLoS ONE | pmid:20957036 |
| Khodadad CL and Foster JS | Metagenomic and metabolic profiling of nonlithifying and lithifying stromatolitic mats of Highborne Cay, The Bahamas. | 2012 | PLoS ONE | pmid:22662280 |
| Tomita Y et al. | Genome and transcriptome analysis of the food-yeast Candida utilis. | 2012 | PLoS ONE | pmid:22629373 |
| Thein M et al. | DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. | 2012 | PLoS ONE | pmid:22590556 |
| Anand K et al. | Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. | 2012 | PLoS ONE | pmid:22574179 |
| Tao X et al. | Digital gene expression analysis based on integrated de novo transcriptome assembly of sweet potato [Ipomoea batatas (L.) Lam]. | 2012 | PLoS ONE | pmid:22558397 |
| Xiao L et al. | Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. | 2012 | PLoS ONE | pmid:22545152 |
| Scalliet G et al. | Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. | 2012 | PLoS ONE | pmid:22536383 |
| Wong YH et al. | Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. | 2012 | PLoS ONE | pmid:22448242 |
| Gueguen C et al. | Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition. | 2014 | PLoS ONE | pmid:24586272 |
| Trushina E et al. | Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. | 2012 | PLoS ONE | pmid:22393443 |
| Tran QM et al. | Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase. | 2012 | PLoS ONE | pmid:22393428 |
| Totir M et al. | Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. | 2012 | PLoS ONE | pmid:22393408 |
| Scotti C et al. | Cell-cycle inhibition by Helicobacter pylori L-asparaginase. | 2010 | PLoS ONE | pmid:21085483 |
| Zuno-Floriano FG et al. | Effect of Acinetobacter sp on metalaxyl degradation and metabolite profile of potato seedlings (Solanum tuberosum L.) alpha variety. | 2012 | PLoS ONE | pmid:22363586 |
| Fujii T and Albarède F | Ab initio calculation of the Zn isotope effect in phosphates, citrates, and malates and applications to plants and soil. | 2012 | PLoS ONE | pmid:22363478 |
| Wang N et al. | Changes in soybean global gene expression after application of lipo-chitooligosaccharide from Bradyrhizobium japonicum under sub-optimal temperature. | 2012 | PLoS ONE | pmid:22348109 |
| ZÃková A et al. | The F(0)F(1)-ATP synthase complex contains novel subunits and is essential for procyclic Trypanosoma brucei. | 2009 | PLoS Pathog. | pmid:19436713 |
| Dolezal P et al. | The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica. | 2010 | PLoS Pathog. | pmid:20333239 |
| Kozjak-Pavlovic V et al. | Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. | 2009 | PLoS Pathog. | pmid:19851451 |
| Cawthon D et al. | Investigation of proton conductance in liver mitochondria of broilers with pulmonary hypertension syndrome. | 2004 | Poult. Sci. | pmid:14979578 |
| Dongmei H et al. | Synthesis and analgesic activity of N,N'-dicarbonyltryptamines. | 2000 | Prep. Biochem. Biotechnol. | pmid:10919562 |
| Kagawa Y | ATP synthase: from single molecule to human bioenergetics. | 2010 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:20689227 |
| Wada H et al. | Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9037098 |
| Calkins MJ et al. | Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15611470 |
| Pain F et al. | In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12136134 |
| LIFSON N and STOLEN JA | Metabolism of C13-carboxyl-labeled malonate by the intact mouse. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:15440851 |
| Risquez A et al. | Effects of malonate administration on renal ammoniagenesis in intact dogs. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2602392 |
| POTTER VR and SIMONSON H | Sequential blocking of metabolic pathways in vivo. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816386 |
| Li J et al. | Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. | 2013 | Protein Cell | pmid:23807634 |
| Scheer JM et al. | Malonate-assisted purification of human caspases. | 2005 | Protein Expr. Purif. | pmid:15802232 |
| Maertens B et al. | Gene optimization mechanisms: a multi-gene study reveals a high success rate of full-length human proteins expressed in Escherichia coli. | 2010 | Protein Sci. | pmid:20506237 |
| McPherson A | A comparison of salts for the crystallization of macromolecules. | 2001 | Protein Sci. | pmid:11266627 |
| Jung JW et al. | The active site and substrates binding mode of malonyl-CoA synthetase determined by transferred nuclear Overhauser effect spectroscopy, site-directed mutagenesis, and comparative modeling studies. | 2000 | Protein Sci. | pmid:10933494 |
| Nam KH et al. | Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure. | 2009 | Proteins | pmid:18831047 |
| Dharmarajan L et al. | Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate. | 2011 | Proteins | pmid:21491491 |
| Hariharan M and Allewell NM | Effects of the T-->R transition on the electrostatic properties of E. coli aspartate transcarbamylase. | 1998 | Proteins | pmid:9714159 |
| Sivagnanam K et al. | Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose. | 2011 | Proteome Sci | pmid:22008648 |
| Fang X et al. | Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons. | 2011 | Proteome Sci | pmid:21569547 |
| Hou Y et al. | Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages. | 2010 | Proteome Sci | pmid:20822545 |
| Okoli AS et al. | Effects of human and porcine bile on the proteome of Helicobacter hepaticus. | 2012 | Proteome Sci | pmid:22533459 |
| Begg AC et al. | Radiosensitization in vitro by cis-diammine (1,1-cyclobutanedicarboxylato) platinum(II) (carboplatin, JM8) and ethylenediammine-malonatoplatinum(II) (JM40). | 1987 | Radiother Oncol | pmid:3303163 |
| Oswald CB et al. | Disposition of cisplatin derivatives -3H-cis-1,2-diaminocyclohexanedichloroplatinum (II) and 3H-cis-1,2-diaminocyclohexanemalonatoplatinum (II) in BDF1 mice. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2749002 |
| Chen AM et al. | Identification of a TRAP transporter for malonate transport and its expression regulated by GtrA from Sinorhizobium meliloti. | 2010 | Res. Microbiol. | pmid:20594941 |
| Neguţ M et al. | [Value of some enzyme tests used in practice for identification of enterobacteria]. | 1977 Apr-Jun | Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol | pmid:143713 |
| Prahoveanu E et al. | The effect of malonate on succinic dehydrogenase (SDH) activity during the multiplication of influenza and herpes viruses in the embryonate hen egg. | 1974 | Rev Roum Virol | pmid:4465902 |
| Affranchino JL and Stoppani AO | [Existence of 2 sites of oxidative phosphorylation in Trypanosoma cruzi]. | 1985 | Rev. Argent. Microbiol. | pmid:3916670 |
| Nikiforov AA and Ostretsova IB | Effects of metabolic substrates and inhibitors on weak organic anion transport in rat renal proximal tubules. | 1997 May-Jun | Ross Fiziol Zh Im I M Sechenova | pmid:13677672 |
| Müller SC et al. | The structure of the core of the spiral wave in the belousov-zhabotinskii reaction. | 1985 | Science | pmid:17797290 |