| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Abscess | D000038 | 13 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang YB et al. | Geometry analysis and systematic synthesis of highly porous isoreticular frameworks with a unique topology. | 2012 | Nat Commun | pmid:22273680 |
| Schmelz S et al. | AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. | 2009 | Nat. Chem. Biol. | pmid:19182782 |
| Sloan JL et al. | Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. | 2011 | Nat. Genet. | pmid:21841779 |
| Xi ZX et al. | Brain cannabinoid CBâ‚‚ receptors modulate cocaine's actions in mice. | 2011 | Nat. Neurosci. | pmid:21785434 |
| Sinha AK et al. | Microwave-assisted rapid synthesis of methyl 2,4,5-trimethoxyphenylpropionate, a metabolite of Cordia alliodora. | 2003 | Nat. Prod. Res. | pmid:14577691 |
| Kagan ML et al. | Geometric phase shifts in chemical oscillators. | 1991 | Nature | pmid:1992353 |
| Hsieh YC et al. | MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. | 2011 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:21667279 |
| Preuss HG et al. | Correlation between glutamate deamination and glutamine deamidation in rat kidney mitochondria. | 1981 | Nephron | pmid:7266713 |
| van Groeningen CJ et al. | Comparison of two different high doses of metoclopramide in the prevention of chemotherapy-induced emesis. | 1989 | Neth J Med | pmid:2699653 |
| Sivananthan SN and Leavitt BR | Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice. | 2011 | Neurobiol. Aging | pmid:21741126 |
| Young KC et al. | Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. | 2007 | Neurobiol. Dis. | pmid:17240155 |
| Fernandez-Gomez FJ et al. | Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death. | 2005 | Neurobiol. Dis. | pmid:16242643 |
| Klivenyi P et al. | Mice lacking alpha-synuclein are resistant to mitochondrial toxins. | 2006 | Neurobiol. Dis. | pmid:16298531 |
| Petersén A et al. | Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice. | 2002 | Neurobiol. Dis. | pmid:12460553 |
| Yang L et al. | A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. | 2004 | Neurobiol. Dis. | pmid:15474362 |
| Yang L et al. | Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. | 2009 | Neurobiol. Dis. | pmid:19660549 |
| Miglio G et al. | PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. | 2009 | Neurochem. Int. | pmid:19442697 |
| Maragos WF et al. | Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. | 2004 | Neurochem. Res. | pmid:15098936 |
| Lu GW et al. | Alteration of oxygen consumption and energy metabolism during repetitive exposure of mice to hypoxia. | 1999 | Neurochem. Res. | pmid:10344590 |
| Benjamin AM and Verjee ZH | Control of aerobic glycolysis in the brain in vitro. | 1980 | Neurochem. Res. | pmid:7207696 |
| Saad LO et al. | Lactate dehydrogenase activity is inhibited by methylmalonate in vitro. | 2006 | Neurochem. Res. | pmid:16758363 |
| Vagner T et al. | Nucleic Acid-Based Therapy Approaches for Huntington's Disease. | 2012 | Neurol Res Int | pmid:22288011 |
| Fancellu R et al. | Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum. | 2003 | Neurol. Sci. | pmid:14598076 |
| Mossakowski MJ et al. | Effect of sodium glutamate on the morphology and histochemistry of experimental gliopathy induced in vitro by ammonia and sodium malonate. | 1975 Jan-Mar | Neuropatol Pol | pmid:1118055 |
| Gołembiowska K and Dziubina A | Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. | 2004 | Neuropharmacology | pmid:15275831 |
| Connop BP et al. | Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase. | 1996 | Neuropharmacology | pmid:8793908 |
| López-Muñoz F et al. | The history of barbiturates a century after their clinical introduction. | 2005 | Neuropsychiatr Dis Treat | pmid:18568113 |
| Frank S | Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease. | 2010 | Neuropsychiatr Dis Treat | pmid:20957126 |
| Spindler M et al. | Coenzyme Q10 effects in neurodegenerative disease. | 2009 | Neuropsychiatr Dis Treat | pmid:19966907 |
| Lecanu L et al. | Deleterious Ca-independent NOS activity after oxidative stress in rat striatum. | 1998 | Neuroreport | pmid:9512406 |
| Tao Y et al. | Effects of glucagon on axoplasmic transport in mouse superior cervical ganglion cells. | 1999 | Neuroreport | pmid:10439471 |
| Meldrum A et al. | Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicity. | 2001 | Neuroreport | pmid:11201098 |
| Lastres-Becker I et al. | Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. | 2003 | Neuroreport | pmid:12858038 |
| Asanuma T et al. | Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping. | 2002 | Neurosci. Lett. | pmid:12183031 |
| Asanuma T et al. | Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method. | 2004 | Neurosci. Lett. | pmid:15050711 |
| Davolio C and Greenamyre JT | Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. | 1995 | Neurosci. Lett. | pmid:7675303 |
| Kalonia H et al. | Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats. | 2010 | Neuroscience | pmid:20813166 |
| Guyot MC et al. | Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats. | 1997 | Neuroscience | pmid:9300407 |
| Calingasan NY et al. | Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. | 2008 | Neuroscience | pmid:18423880 |
| Fernandez-Gomez FJ et al. | Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. | 2005 | Neuroscience | pmid:15964487 |
| Schurr A and Payne RS | Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study. | 2007 | Neuroscience | pmid:17560727 |
| Schulz JB et al. | Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. | 1996 | Neuroscience | pmid:8684608 |
| Zeevalk GD et al. | Oxidative stress during energy impairment in mesencephalic cultures is not a downstream consequence of a secondary excitotoxicity. | 2000 | Neuroscience | pmid:10683571 |
| Mallajosyula JK et al. | Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. | 2009 | Neurotox Res | pmid:19526285 |
| Buchman VL and Ninkina N | Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze? | 2008 | Neurotox Res | pmid:19073436 |
| Antkiewicz-Michaluk L et al. | Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release. | 2011 | Neurotox Res | pmid:21069490 |
| Playsted CW et al. | Functional significance of dauciform roots: exudation of carboxylates and acid phosphatase under phosphorus deficiency in Caustis blakei (Cyperaceae). | 2006 | New Phytol. | pmid:16626471 |
| van Schöll L et al. | Organic anion exudation by ectomycorrhizal fungi and Pinus sylvestris in response to nutrient deficiencies. | 2006 | New Phytol. | pmid:16539612 |
| Miki T | [Inhibitors of complex I and II of the mitochondrial respiratory chain]. | 2002 | Nippon Rinsho | pmid:12013844 |
| Ling F et al. | A role for MHR1, a gene required for mitochondrial genetic recombination, in the repair of damage spontaneously introduced in yeast mtDNA. | 2000 | Nucleic Acids Res. | pmid:11121487 |