Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Lê-Quôc K et al. Evidence for the existence of two classes of sulfhydryl groups essential for membrane-bound succinate dehydrogenase activity. 1981 Biochemistry pmid:7225354
Ferrero J et al. Efflux of inorganic phosphate from mammalian non-myelinated nerve fibres. 1978 J. Physiol. (Lond.) pmid:722557
Preuss HG et al. Correlation between glutamate deamination and glutamine deamidation in rat kidney mitochondria. 1981 Nephron pmid:7266713
Pietrobon D et al. Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'. 1981 Eur. J. Biochem. pmid:7274216
Pritchard DJ Transdifferentiation of chicken embryo neural retina into pigment epithelium: indications of its biochemical basis. 1981 J Embryol Exp Morphol pmid:7276821
Alsaadi BM et al. A pmr study of the effects of pH and anion and metal ion binding of the histidyl residues of ovotransferrin. 1981 J. Inorg. Biochem. pmid:7276935
Ford WC and Harrison A The role of oxidative phosphorylation in the generation of ATP in human spermatozoa. 1981 J. Reprod. Fertil. pmid:7277330
Lee KH et al. Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents. 1981 J. Med. Chem. pmid:7328595
Konishi K et al. A Halophilic vibrio isolated from a case of chronic cholecystitis. 1981 Microbiol. Immunol. pmid:7334940
Emery T Malonichrome, a new iron chelate from Fusarium roseum. 1980 Biochim. Biophys. Acta pmid:7388041
Tihanyi K et al. Effect of succinate on aminopyrine N-demethylase activity. 1980 Biochim. Biophys. Acta pmid:7388048
Kara TC and Patnaik BK Age-related changes in oxygen consumption and the SDH activity of liver homogenate of male garden lizards: effect of malonate and short-term cold stress. 1980 Gerontology pmid:7390165
Aizawa M et al. Immobilized mitochondrial electron transport particle for NADH determination. 1980 Biotechnol. Bioeng. pmid:7407338
Koeppen AH et al. Lipid labeling after intracerebral injection of radioactive malonic acid. 1980 J. Neurochem. pmid:7411143
Garg DN et al. The sero-fermentative-phage types of Salmonella weltevreden. 1980 Zentralbl Bakteriol A pmid:7434993
Saint-Macary M and Foucher B Binding of malonate to the inner membrane of rat liver mitochondria. 1980 Biochem. Biophys. Res. Commun. pmid:7437047
Masterson E and Chader GJ Pigment epithelial cells in culture. Metabolic pathways required for phagocytosis. 1981 Invest. Ophthalmol. Vis. Sci. pmid:7451071
Parvin R et al. Inhibition of mitochondrial carnitine-acylcarnitine translocase by sulfobetaines. 1980 Can. J. Biochem. pmid:7459685
Ye B et al. L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. 1995 J. Med. Chem. pmid:7473554
Jocelyn PC The reduction of diamide by rat liver mitochondria and the role of glutathione. 1978 Biochem. J. pmid:747642
Maragos WF and Silverstein FS The mitochondrial inhibitor malonate enhances NMDA toxicity in the neonatal rat striatum. 1995 Brain Res. Dev. Brain Res. pmid:7493402
Schmehl I et al. Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. 1995 FEBS Lett. pmid:7498500
Greene JG and Greenamyre JT Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. 1995 J. Neurochem. pmid:7536810
Maragos WF and Silverstein FS Inhibition of nitric oxide synthase activity attenuates striatal malonate lesions in rats. 1995 J. Neurochem. pmid:7536812
Bazzett TJ et al. Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum. 1995 Exp. Neurol. pmid:7556544
Cheng Y et al. pH dependence of specific divalent anion binding to the N-lobe of recombinant human transferrin. 1995 Biochemistry pmid:7578099
Messam CA et al. Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. 1995 Brain Res. pmid:7583227
Sánchez-Alcázar JA et al. Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. 1995 J. Biol. Chem. pmid:7592589
Schulz JB et al. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. 1995 J. Cereb. Blood Flow Metab. pmid:7593355
Matalon R et al. Malonic aciduria and cardiomyopathy. 1993 J. Inherit. Metab. Dis. pmid:7609455
Armson A et al. The effect of electron transport (ET) inhibitors and thiabendazole on the fumarate reductase (FR) and succinate dehydrogenase (SDH) of Strongyloides ratti infective (L3) larvae. 1995 Int. J. Parasitol. pmid:7622334
Raginskaia VP [Nomenclature of the S. coli (E. coli) No. 2624/36 and 5396/38 strains]. 1975 Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:766529
O'Donnell M et al. Evidence from affinity precipitation that glutamate analogues are bound in a folded conformation to glutamate dehydrogenase. 1995 Biochem. Soc. Trans. pmid:7672393
Davolio C and Greenamyre JT Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. 1995 Neurosci. Lett. pmid:7675303
Klein BY et al. Selection of malonate-resistant stromal cell-derived osteoprogenitor cells in vitro. 1993 J. Cell. Biochem. pmid:7680046
Beal MF et al. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. 1993 J. Neurochem. pmid:7689641
Byun HS and Kim YS Assays for malonate decarboxylase. 1994 Anal. Biochem. pmid:7695096
Davydov VV et al. [Effect of malonate on various aspects of hepatic metabolism]. 1994 Oct-Dec Patol Fiziol Eksp Ter pmid:7700705
Schuster H et al. Substrate and product binding sites of yeast fatty acid synthase. Stoichiometry and binding kinetics of wild-type and in vitro mutated enzymes. 1995 Eur. J. Biochem. pmid:7705357
Dehning I and Schink B Anaerobic degradation of malonate via malonyl-CoA by Sporomusa malonica, Klebsiella oxytoca, and Rhodobacter capsulatus. 1994 Antonie Van Leeuwenhoek pmid:7710283
Ermayanti TM et al. Stimulation of synthesis and release of swainosonine from transformed roots of Swainsona galegifolia. 1994 Phytochemistry pmid:7764877
Klein BY et al. Analysis of cell-mediated mineralization in culture of bone-derived embryonic cells with neurofibromatosis. 1995 J. Cell. Biochem. pmid:7768987
Kirschner PB et al. Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. 1995 J. Cereb. Blood Flow Metab. pmid:7790410
Nieva-Gomez D and Konisky J Membrane changes in Escherichia coli induced by colicin Ia and agents known to disrupt energy transduction. 1976 Biochemistry pmid:779829
Oldendorf WH et al. Transient blood-brain barrier passage of polar compounds at low pH. 1994 Am. J. Physiol. pmid:7810722
Brand MD et al. The sum of flux control coefficients in the electron-transport chain of mitochondria. 1994 Eur. J. Biochem. pmid:7813471
Kim YS and Kim EJ A plasmid responsible for malonate assimilation in Pseudomonas fluorescens. 1994 Plasmid pmid:7846146
Ray S et al. Inhibition of electron flow through complex I of the mitochondrial respiratory chain of Ehrlich ascites carcinoma cells by methylglyoxal. 1994 Biochem. J. pmid:7945267
Beal MF et al. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. 1994 Ann. Neurol. pmid:7998775
Reiss U and Rothstein M Age-related changes in isocitrate lyase from the free living nematode, Turbatrix aceti. 1975 J. Biol. Chem. pmid:803500