Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Acne Keloid D000153 1 associated lipids
Alopecia Areata D000506 6 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Drug Eruptions D003875 30 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Erythema D004890 22 associated lipids
Facial Dermatoses D005148 7 associated lipids
Heart Failure D006333 36 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

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Authors Title Published Journal PubMed Link
Elewski BE et al. In reference to the October 2004 comprehensive overview of rosacea therapy. 2007 J. Am. Acad. Dermatol. pmid:17870440
Gupta AK et al. The treatment of melasma: a review of clinical trials. 2006 J. Am. Acad. Dermatol. pmid:17097400
Maddin S A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea. 1999 J. Am. Acad. Dermatol. pmid:10365928
Chen Z et al. Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. 2008 J. Am. Chem. Soc. pmid:18278910
Bojar RA et al. The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. 1991 J. Antimicrob. Chemother. pmid:1726169
Maple PA et al. Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. 1992 J. Antimicrob. Chemother. pmid:1506349
Bojar RA et al. Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. 1994 J. Antimicrob. Chemother. pmid:7829407
Bojar RA et al. Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. 1988 J. Appl. Bacteriol. pmid:2459099
Gołębiowski M et al. Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. 2014 J. Appl. Microbiol. pmid:24238211
Vermis K et al. Burkholderia cepacia complex genomovars: utilization of carbon sources, susceptibility to antimicrobial agents and growth on selective media. 2003 J. Appl. Microbiol. pmid:14632991