Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

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Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

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What functions are associated with Azelaic acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

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What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

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Authors Title Published Journal PubMed Link
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McLean DI and Peter KK Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. 1986 Br. J. Dermatol. pmid:3718862
Mayer-da Silva A et al. Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. 1987 Acta Derm. Venereol. pmid:2438874
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Grosshans E and Chartier C [Therapeutic depigmentation agents]. 1987 Schweiz. Rundsch. Med. Prax. pmid:3671942
Schallreuter KU and Wood JM Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. 1987 Cancer Lett. pmid:3652030
Bojar RA et al. Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. 1988 J. Appl. Bacteriol. pmid:2459099
Mingrone G et al. Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. 1988 Q J Exp Physiol pmid:3164112
Piquero Martín J et al. [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. 1988 Med Cutan Ibero Lat Am pmid:3073279
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Breathnach AS et al. Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. 1989 Invest. Ophthalmol. Vis. Sci. pmid:2925320
Giannotti B [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. 1989 G Ital Dermatol Venereol pmid:2534552
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Breathnach AS et al. Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2672685
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Detmar M et al. Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. 1989 J. Invest. Dermatol. pmid:2473140
Mayer-da-Silva A et al. Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2475995
Töpert M et al. Pharmacology and toxicology of azelaic acid. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528255
Cunliffe WJ and Holland KT Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528256
Katsambas A et al. Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528257
Cavicchini S and Caputo R Long-term treatment of acne with 20% azelaic acid cream. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528258
Hjorth N and Graupe K Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528259
Verallo-Rowell VM et al. Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528260
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Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2773613
Nazzaro-Porro M et al. Ten years' experience of treating lentigo maligna with topical azelaic acid. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2773614
Nüssgen AI et al. Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2773615
Flamigni F et al. Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. 1989 Biochem. J. pmid:2719637
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Daverat P et al. Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. 1989 J. Neuroimmunol. pmid:2925840
Jorand JP et al. The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. 1989 Horm. Metab. Res. pmid:2807145
Breathnach AC et al. Azelaic acid therapy in disorders of pigmentation. 1989 Apr-Jun Clin. Dermatol. pmid:2667735
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Schallreuter KU and Wood JW A possible mechanism of action for azelaic acid in the human epidermis. 1990 Arch. Dermatol. Res. pmid:2114832
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Tacchino RM et al. Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry. 1990 Mar-Apr JPEN J Parenter Enteral Nutr pmid:2112625
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Maple PA et al. Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. 1992 J. Antimicrob. Chemother. pmid:1506349
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