| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Acne Keloid | D000153 | 1 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Keratosis | D007642 | 9 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Melanosis | D008548 | 4 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pituitary Apoplexy | D010899 | 1 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Rhinophyma | D012224 | 1 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nazzaro-Porro M et al. | Effect of dicarboxylic acids on lentigo maligna. | 1979 | J. Invest. Dermatol. | pmid:448162 |
| Robins EJ et al. | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. | 1985 | Br. J. Dermatol. | pmid:4096883 |
| Leibl H et al. | Inhibition of DNA synthesis of melanoma cells by azelaic acid. | 1985 | J. Invest. Dermatol. | pmid:4056455 |
| Pathak MA et al. | An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1985 | J. Invest. Dermatol. | pmid:4031538 |
| Robins EJ et al. | Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. | 1985 | J. Invest. Dermatol. | pmid:4031537 |
| Picardo M et al. | Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts. | 1985 | Biochem. Pharmacol. | pmid:4004885 |
| Rocchiccioli F et al. | Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. | 1986 | Pediatr. Res. | pmid:3945517 |
| Hu F et al. | Effects of dicarboxylic acids on normal and malignant melanocytes in culture. | 1986 | Br. J. Dermatol. | pmid:3942687 |
| Ortonne JP | [Depigmenting chemical agents]. | 1986 | Ann Dermatol Venereol | pmid:3800227 |
| Ward BJ et al. | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. | 1986 | J. Invest. Dermatol. | pmid:3745962 |
| Robins EJ et al. | Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1986 | J. Invest. Dermatol. | pmid:3734479 |
| McLean DI and Peter KK | Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. | 1986 | Br. J. Dermatol. | pmid:3718862 |
| Geier G et al. | [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. | 1986 | Hautarzt | pmid:3700102 |
| Grosshans E and Chartier C | [Therapeutic depigmentation agents]. | 1987 | Schweiz. Rundsch. Med. Prax. | pmid:3671942 |
| Schallreuter KU and Wood JM | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. | 1987 | Cancer Lett. | pmid:3652030 |
| Azelaic acid in lentigo maligna. | 1987 | Br. J. Dermatol. | pmid:3580294 | |
| Sowden J et al. | Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid. | 1988 | Clin. Exp. Dermatol. | pmid:3256454 |
| Stamatiadis D et al. | Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. | 1988 | Br. J. Dermatol. | pmid:3207614 |
| Mingrone G et al. | Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. | 1988 | Q J Exp Physiol | pmid:3164112 |
| Piquero MartÃn J et al. | [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. | 1988 | Med Cutan Ibero Lat Am | pmid:3073279 |
| Nazzaro-Porro M | Azelaic acid. | 1987 | J. Am. Acad. Dermatol. | pmid:2963038 |
| Auld J | Topical therapy of acne. | 1986 | Australas. J. Dermatol. | pmid:2957990 |
| Leeming JP et al. | The in vitro antimicrobial effect of azelaic acid. | 1986 | Br. J. Dermatol. | pmid:2947607 |
| Bladon PT et al. | Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. | 1986 | Br. J. Dermatol. | pmid:2938615 |
| Gassmueller H et al. | Azelaic acid and sebum excretion rate. | 1985 | Br. J. Dermatol. | pmid:2937439 |
| Daverat P et al. | Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. | 1989 | J. Neuroimmunol. | pmid:2925840 |
| Breathnach AS et al. | Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2925320 |
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| Jorand JP et al. | The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. | 1989 | Horm. Metab. Res. | pmid:2807145 |
| pmid:27956183 | ||||
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| Samycia M and Lam JM | Infantile acne. | 2016 | CMAJ | pmid:27873756 |
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| Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
| Nazzaro-Porro M et al. | Ten years' experience of treating lentigo maligna with topical azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773614 |
| Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773613 | |
| Rigoni C et al. | [Use of a cream based on 20% azelaic acid in the treatment of melasma]. | 1989 Jan-Feb | G Ital Dermatol Venereol | pmid:2767714 |
| Lim GH et al. | Role of plasmodesmata and plasmodesmata localizing proteins in systemic immunity. | 2016 | Plant Signal Behav | pmid:27645210 |
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| Helfrich YR and Maier LM | Topical and oral therapeutic approach to rosacea. | 2016 | Semin Cutan Med Surg | pmid:27416312 |
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