| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Acne Keloid | D000153 | 1 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Keratosis | D007642 | 9 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Melanosis | D008548 | 4 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pituitary Apoplexy | D010899 | 1 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Rhinophyma | D012224 | 1 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Elewski BE et al. | In reference to the October 2004 comprehensive overview of rosacea therapy. | 2007 | J. Am. Acad. Dermatol. | pmid:17870440 |
| Gupta AK et al. | The treatment of melasma: a review of clinical trials. | 2006 | J. Am. Acad. Dermatol. | pmid:17097400 |
| Maddin S | A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea. | 1999 | J. Am. Acad. Dermatol. | pmid:10365928 |
| Chen Z et al. | Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. | 2008 | J. Am. Chem. Soc. | pmid:18278910 |
| Bojar RA et al. | The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. | 1991 | J. Antimicrob. Chemother. | pmid:1726169 |
| Maple PA et al. | Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. | 1992 | J. Antimicrob. Chemother. | pmid:1506349 |
| Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
| Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
| Gołębiowski M et al. | Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. | 2014 | J. Appl. Microbiol. | pmid:24238211 |
| Vermis K et al. | Burkholderia cepacia complex genomovars: utilization of carbon sources, susceptibility to antimicrobial agents and growth on selective media. | 2003 | J. Appl. Microbiol. | pmid:14632991 |
| Shirokova E et al. | Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. | 2005 | J. Biol. Chem. | pmid:15598656 |
| Yu JS and Kim AK | Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells. | 2010 | J. Biomed. Sci. | pmid:20804622 |
| De Filippis D et al. | Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. | 2009 | J. Cell. Mol. Med. | pmid:18429935 |
| Nojima S et al. | Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus. | 2007 | J. Chem. Ecol. | pmid:17394050 |
| Yoon TY et al. | A case of idiopathic eruptive macular pigmentation. | 2004 | J. Dermatol. | pmid:15187318 |
| Erbil H et al. | Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. | 2007 | J. Dermatol. | pmid:17204097 |
| Oh CW and Myung KB | An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. | 1996 | J. Dermatol. | pmid:8935627 |
| Wittek F et al. | Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. | 2014 | J. Exp. Bot. | pmid:25114016 |
| Chae K et al. | A multifaceted study of stigma/style cysteine-rich adhesin (SCA)-like Arabidopsis lipid transfer proteins (LTPs) suggests diversified roles for these LTPs in plant growth and reproduction. | 2010 | J. Exp. Bot. | pmid:20667964 |
| Yu L et al. | Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry. | 2011 | J. Gastroenterol. Hepatol. | pmid:21443661 |
| JANOTA-BASSALIK L and WRIGHT LD | AZELAIC ACID UTILIZATION BY A PSEUDOMONAS. | 1964 | J. Gen. Microbiol. | pmid:14217352 |
| Brune TG et al. | Unknown peaks in GC-MS analyses of Guthrie cards blood samples might be the result of sample contamination by the black markings of the card. | 2002 | J. Inherit. Metab. Dis. | pmid:12555947 |
| Korman SH et al. | Characteristic urine organic acid profile in peroxisomal biogenesis disorders. | 2000 | J. Inherit. Metab. Dis. | pmid:10896310 |
| Robins EJ et al. | Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. | 1985 | J. Invest. Dermatol. | pmid:4031537 |
| Melnik BC et al. | Anti-acne agents attenuate FGFR2 signal transduction in acne. | 2009 | J. Invest. Dermatol. | pmid:19225542 |
| Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
| Robins EJ et al. | Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1986 | J. Invest. Dermatol. | pmid:3734479 |
| Ward BJ et al. | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. | 1986 | J. Invest. Dermatol. | pmid:3745962 |
| Pathak MA et al. | An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1985 | J. Invest. Dermatol. | pmid:4031538 |
| Leibl H et al. | Inhibition of DNA synthesis of melanoma cells by azelaic acid. | 1985 | J. Invest. Dermatol. | pmid:4056455 |
| Nazzaro-Porro M et al. | Effect of dicarboxylic acids on lentigo maligna. | 1979 | J. Invest. Dermatol. | pmid:448162 |
| Clark AA et al. | Odorants specifically modulate chemotaxis and tissue retention of CD4+ T cells via cyclic adenosine monophosphate induction. | 2016 | J. Leukoc. Biol. | pmid:27154353 |
| Kawai Y et al. | Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modified protein. | 2003 | J. Lipid Res. | pmid:12700336 |
| Passi S et al. | Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631243 |
| Januszewski AS et al. | Chemical modification of proteins during peroxidation of phospholipids. | 2005 | J. Lipid Res. | pmid:15805546 |
| Seidler J et al. | Identification and prediction of promiscuous aggregating inhibitors among known drugs. | 2003 | J. Med. Chem. | pmid:14521410 |
| Daverat P et al. | Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. | 1989 | J. Neuroimmunol. | pmid:2925840 |
| Cluzeau J and Lubell WD | Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate. | 2004 | J. Org. Chem. | pmid:14987004 |
| Gwak HS et al. | Analgesic effects of intra-nasal enkephalins. | 2003 | J. Pharm. Pharmacol. | pmid:14604463 |
| Zheng P et al. | A novel urinary metabolite signature for diagnosing major depressive disorder. | 2013 | J. Proteome Res. | pmid:24224655 |
| Staroverov SA et al. | Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma. | 2011 | J. Vet. Sci. | pmid:22122895 |
| Tacchino RM et al. | Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry. | 1990 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:2112625 |
| Mingrone G et al. | Preliminary studies of a dicarboxylic acid as an energy substrate in man. | 1989 May-Jun | JPEN J Parenter Enteral Nutr | pmid:2503641 |
| Nazzaro-Porro M et al. | Effect of azelaic acid on human malignant melanoma. | 1980 | Lancet | pmid:6103442 |
| Azelaic acid, a new treatment for rosacea. | 2004 | Mayo Clin Womens Healthsource | pmid:15152174 | |
| Piquero MartÃn J et al. | [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. | 1988 | Med Cutan Ibero Lat Am | pmid:3073279 |
| Azelaic acid (Finacea) for rosacea. | 2003 | Med Lett Drugs Ther | pmid:12968125 | |
| Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
| Gollnick H | [Azelaic acid for keratinization disorders?]. | 1991 | Med Monatsschr Pharm | pmid:1838401 |
| Breathnach AS | Azelaic acid: potential as a general antitumoural agent. | 1999 | Med. Hypotheses | pmid:10362281 |
| Reis CP et al. | Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles. | 2013 | Microsc. Microanal. | pmid:23673203 |
| Schnopp C and Mempel M | Acne vulgaris in children and adolescents. | 2011 | Minerva Pediatr. | pmid:21909065 |
| Koczorek M | ["Cleansing, topical treatment, oral administration". Controlling acne]. | 2001 | MMW Fortschr Med | pmid:11524979 |
| Muthulakshmi S and Saravanan R | Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice. | 2013 | Mol. Cell. Biochem. | pmid:23361364 |
| Grammatico P et al. | Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. | 1993 | Mutat. Res. | pmid:7685492 |
| Garelnabi M et al. | Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples. | 2010 | N Am J Med Sci | pmid:22558586 |
| Chagnaud JL et al. | Monoclonal anti-conjugated azelaic acid antibody production: application to multiple sclerosis. | 1990 | Neuroreport | pmid:2129868 |
| Roebuck HL | Face up to rosacea. | 2005 | Nurse Pract | pmid:16151303 |
| U-Taniguchi Y et al. | Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. | 1995 | Oncol. Res. | pmid:8555652 |
| Gung BW and Dickson H | Total synthesis of (-)-minquartynoic acid: an anti-cancer, anti-HIV natural product. | 2002 | Org. Lett. | pmid:12123365 |
| Preisz K and Kárpáti S | [Rosacea: pathogenesis, clinical forms and therapy]. | 2010 | Orv Hetil | pmid:20650811 |
| Culp B and Scheinfeld N | Rosacea: a review. | 2009 | P T | pmid:19562004 |
| Goulden V | Guidelines for the management of acne vulgaris in adolescents. | 2003 | Paediatr Drugs | pmid:12716217 |
| Jansen T et al. | Steroid-induced periorificial dermatitis in children--clinical features and response to azelaic acid. | 2010 Mar-Apr | Pediatr Dermatol | pmid:19804495 |
| Rocchiccioli F et al. | Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. | 1986 | Pediatr. Res. | pmid:3945517 |
| Herkenne C et al. | In vivo methods for the assessment of topical drug bioavailability. | 2008 | Pharm. Res. | pmid:17985216 |
| Pattarino F et al. | Topical delivery systems for azelaic acid: effect of the suspended drug in microemulsion. | 1994 | Pharmazie | pmid:8140138 |
| Duteil L and Ortonne JP | Colorimetric assessment of the effects of azelaic acid on light-induced skin pigmentation. | 1992 | Photodermatol Photoimmunol Photomed | pmid:1489719 |
| Polis BD et al. | Studies on PGBx, a polymeric derivative of prostaglandin B1: I. Synthesis and purification of PGBx. | 1979 | Physiol. Chem. Phys. | pmid:482383 |
| Rodriguez-Vicente J et al. | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. | 1996 | Pigment Cell Res. | pmid:9125756 |
| Chaturvedi R et al. | An abietane diterpenoid is a potent activator of systemic acquired resistance. | 2012 | Plant J. | pmid:22385469 |
| Truman WM et al. | Arabidopsis auxin mutants are compromised in systemic acquired resistance and exhibit aberrant accumulation of various indolic compounds. | 2010 | Plant Physiol. | pmid:20081042 |
| Zoeller M et al. | Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid. | 2012 | Plant Physiol. | pmid:22822212 |
| Chaouch S et al. | Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner. | 2010 | Plant Physiol. | pmid:20543092 |
| Xia Y et al. | The glabra1 mutation affects cuticle formation and plant responses to microbes. | 2010 | Plant Physiol. | pmid:20699396 |
| Lim GH et al. | Role of plasmodesmata and plasmodesmata localizing proteins in systemic immunity. | 2016 | Plant Signal Behav | pmid:27645210 |
| Fabbrocini G et al. | Skin needling to enhance depigmenting serum penetration in the treatment of melasma. | 2011 | Plast Surg Int | pmid:22567235 |
| Estronca LM et al. | Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model. | 2012 | PLoS ONE | pmid:22514671 |
| Gordy JW et al. | Comparative Effectiveness of Potential Elicitors of Plant Resistance against Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) in Four Crop Plants. | 2015 | PLoS ONE | pmid:26332833 |
| Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
| von Schönfels W et al. | Metabolic signature of electrosurgical liver dissection. | 2013 | PLoS ONE | pmid:24058442 |
| Elsaie ML and Choudhary S | Updates on the pathophysiology and management of acne rosacea. | 2009 | Postgrad Med | pmid:19820288 |
| Scheinfeld N and Berk T | A review of the diagnosis and treatment of rosacea. | 2010 | Postgrad Med | pmid:20107297 |
| Mingrone G et al. | Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. | 1988 | Q J Exp Physiol | pmid:3164112 |
| Lanz C et al. | Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. | 2009 | Radiat. Res. | pmid:19630524 |
| LaFranchi BW et al. | Photoelectron resonance capture ionization mass spectrometry: a soft ionization source for mass spectrometry of particle-phase organic compounds. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15468105 |
| Grosshans E and Chartier C | [Therapeutic depigmentation agents]. | 1987 | Schweiz. Rundsch. Med. Prax. | pmid:3671942 |
| Parker JE | The quest for long-distance signals in plant systemic immunity. | 2009 | Sci Signal | pmid:19436056 |
| Jung HW et al. | Priming in systemic plant immunity. | 2009 | Science | pmid:19342588 |
| Han S et al. | Application of HPLC with ELSD detection for the assessment of azelaic acid impurities in liposomal formulation. | 2013 | ScientificWorldJournal | pmid:24228008 |
| Helfrich YR and Maier LM | Topical and oral therapeutic approach to rosacea. | 2016 | Semin Cutan Med Surg | pmid:27416312 |
| Sieber MA and Hegel JK | Azelaic acid: Properties and mode of action. | 2014 | Skin Pharmacol Physiol | pmid:24280644 |
| Vargas-Diez E et al. | Azelaic acid in the treatment of acne in adult females: case reports. | 2014 | Skin Pharmacol Physiol | pmid:24280645 |
| Halder RM and Richards GM | Topical agents used in the management of hyperpigmentation. | 2004 Jun-Jul | Skin Therapy Lett. | pmid:15334278 |
| Gooderham M | Rosacea and its topical management. | 2009 | Skin Therapy Lett. | pmid:19330270 |
| Gupta G et al. | Ivermectin 1% cream for rosacea. | 2015 Jul-Aug | Skin Therapy Lett. | pmid:26382711 |
| Fallen RS and Gooderham M | Rosacea: update on management and emerging therapies. | 2012 | Skin Therapy Lett. | pmid:23223767 |
| Pazoki-Toroudi H et al. | Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia. | 2012 Sep-Oct | Skinmed | pmid:23163069 |
| Ganzetti G et al. | Rosacea: could topical azelaic acid and oral tetracyclines modify videocapillaroscopic pattern? | 2014 Mar-Apr | Skinmed | pmid:24933858 |
| Sun H et al. | Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). | 2010 | Stand Genomic Sci | pmid:21304737 |