Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

Download all related citations
Per page 10 20 50 100 | Total 511
Authors Title Published Journal PubMed Link
pmid:26915831
pmid:26919365
pmid:26976734
pmid:27028014
Lim GH et al. Plasmodesmata Localizing Proteins Regulate Transport and Signaling during Systemic Acquired Immunity in Plants. 2016 Cell Host Microbe pmid:27078071
Clark AA et al. Odorants specifically modulate chemotaxis and tissue retention of CD4+ T cells via cyclic adenosine monophosphate induction. 2016 J. Leukoc. Biol. pmid:27154353
Flamigni F et al. Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. 1989 Biochem. J. pmid:2719637
Asai Y et al. Canadian Clinical Practice Guidelines for Rosacea. 2016 J Cutan Med Surg pmid:27207355
Landthaler M et al. [Lentigo of the glans penis]. 1989 Hautarzt pmid:2732050
pmid:27346659
Le Lay C et al. Identification and quantification of antifungal compounds produced by lactic acid bacteria and propionibacteria. 2016 Int. J. Food Microbiol. pmid:27350657
pmid:27352185
pmid:27414241
Helfrich YR and Maier LM Topical and oral therapeutic approach to rosacea. 2016 Semin Cutan Med Surg pmid:27416312
pmid:27417723
pmid:27484346
pmid:27500896
Lim GH et al. Role of plasmodesmata and plasmodesmata localizing proteins in systemic immunity. 2016 Plant Signal Behav pmid:27645210
Rigoni C et al. [Use of a cream based on 20% azelaic acid in the treatment of melasma]. 1989 Jan-Feb G Ital Dermatol Venereol pmid:2767714
Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2773613
Nazzaro-Porro M et al. Ten years' experience of treating lentigo maligna with topical azelaic acid. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2773614
Nüssgen AI et al. Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2773615
pmid:27814413
Samycia M and Lam JM Infantile acne. 2016 CMAJ pmid:27873756
pmid:27874885
pmid:27897372
pmid:27956183
Jorand JP et al. The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. 1989 Horm. Metab. Res. pmid:2807145
pmid:28235481
pmid:28274355
pmid:28304135
pmid:28686770
pmid:28950768
pmid:29040817
Breathnach AS et al. Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. 1989 Invest. Ophthalmol. Vis. Sci. pmid:2925320
Daverat P et al. Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. 1989 J. Neuroimmunol. pmid:2925840
Gassmueller H et al. Azelaic acid and sebum excretion rate. 1985 Br. J. Dermatol. pmid:2937439
Bladon PT et al. Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. 1986 Br. J. Dermatol. pmid:2938615
Leeming JP et al. The in vitro antimicrobial effect of azelaic acid. 1986 Br. J. Dermatol. pmid:2947607
Auld J Topical therapy of acne. 1986 Australas. J. Dermatol. pmid:2957990
Nazzaro-Porro M Azelaic acid. 1987 J. Am. Acad. Dermatol. pmid:2963038
Piquero Martín J et al. [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. 1988 Med Cutan Ibero Lat Am pmid:3073279
Mingrone G et al. Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. 1988 Q J Exp Physiol pmid:3164112
Stamatiadis D et al. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. 1988 Br. J. Dermatol. pmid:3207614
Sowden J et al. Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid. 1988 Clin. Exp. Dermatol. pmid:3256454
Azelaic acid in lentigo maligna. 1987 Br. J. Dermatol. pmid:3580294
Schallreuter KU and Wood JM Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. 1987 Cancer Lett. pmid:3652030
Grosshans E and Chartier C [Therapeutic depigmentation agents]. 1987 Schweiz. Rundsch. Med. Prax. pmid:3671942
Geier G et al. [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. 1986 Hautarzt pmid:3700102
McLean DI and Peter KK Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. 1986 Br. J. Dermatol. pmid:3718862
Robins EJ et al. Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. 1986 J. Invest. Dermatol. pmid:3734479
Ward BJ et al. Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. 1986 J. Invest. Dermatol. pmid:3745962
Ortonne JP [Depigmenting chemical agents]. 1986 Ann Dermatol Venereol pmid:3800227
Hu F et al. Effects of dicarboxylic acids on normal and malignant melanocytes in culture. 1986 Br. J. Dermatol. pmid:3942687
Rocchiccioli F et al. Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. 1986 Pediatr. Res. pmid:3945517
Picardo M et al. Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts. 1985 Biochem. Pharmacol. pmid:4004885
Robins EJ et al. Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. 1985 J. Invest. Dermatol. pmid:4031537
Pathak MA et al. An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. 1985 J. Invest. Dermatol. pmid:4031538
Leibl H et al. Inhibition of DNA synthesis of melanoma cells by azelaic acid. 1985 J. Invest. Dermatol. pmid:4056455
Robins EJ et al. Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. 1985 Br. J. Dermatol. pmid:4096883
Nazzaro-Porro M et al. Effect of dicarboxylic acids on lentigo maligna. 1979 J. Invest. Dermatol. pmid:448162
Dousset N and Douste-Blazy L [Azelaic acid transformation into monocarboxylic fatty acids in vivo in the rat]. 1973 Biochimie pmid:4793585
Polis BD et al. Studies on PGBx, a polymeric derivative of prostaglandin B1: I. Synthesis and purification of PGBx. 1979 Physiol. Chem. Phys. pmid:482383
Solo AJ and Gardner JO Agents for alkylating steroid hormone receptors. 3. Omega-substituted esters of 17-alpha-hydroxyprogesterone. 1971 J Pharm Sci pmid:5115254
Nazzaro-Porro M et al. Effect of azelaic acid on human malignant melanoma. 1980 Lancet pmid:6103442
Nazzaro-Porro M et al. Beneficial effect of 15% azelaic acid cream on acne vulgaris. 1983 Br. J. Dermatol. pmid:6222755
Marsden JR and Shuster S The effect of azelaic acid on acne. 1983 Br. J. Dermatol. pmid:6228247
Breathnach AS et al. Azelaic acid. 1984 Br. J. Dermatol. pmid:6234914
Mingrone G et al. Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. 1984 Exp Pathol pmid:6539234
Passi S et al. Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. 1983 J. Lipid Res. pmid:6631243
[Advances in pigment studies]. 1983 Hautarzt pmid:6678891
Willshaw HE and Rubinstein K Azelaic acid in the treatment of ocular and adnexal malignant melanoma. 1983 Br J Ophthalmol pmid:6848136
Maru U et al. [In vitro diffusion and skin penetration of azelaic preparations: study of correlations]. 1982 May-Jun J Pharm Belg pmid:7131228
Palassis J The sampling and determination of azelaic acid in air. 1978 Am Ind Hyg Assoc J pmid:727120
Grimes PE Melasma. Etiologic and therapeutic considerations. 1995 Arch Dermatol pmid:7492140
Lemic-Stojcevic L et al. Effect of azelaic acid on melanoma cells in culture. 1995 Exp. Dermatol. pmid:7640879
Grammatico P et al. Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. 1993 Mutat. Res. pmid:7685492
Nguyen QH and Bui TP Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. 1995 Int. J. Dermatol. pmid:7737781
Bojar RA et al. Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. 1994 J. Antimicrob. Chemother. pmid:7829407
Banerjee S et al. 2'-(3 alpha-Benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'- dihydrooxazoline-N-oxyl as a potential spin probe for model membranes. 1994 Steroids pmid:7940616
Ferioli V et al. Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization. 1994 Farmaco pmid:8074784
Banerjee S et al. Proxyl nitroxide of lithocholic acid: a potential spin probe for model membranes. 1993 Bioorg. Med. Chem. pmid:8081864
Pattarino F et al. Topical delivery systems for azelaic acid: effect of the suspended drug in microemulsion. 1994 Pharmazie pmid:8140138
Bojar RA et al. Follicular concentrations of azelaic acid after a single topical application. 1993 Br. J. Dermatol. pmid:8217752
Zhang EJ et al. [Chemical constituents from the bark of Hibiscus syriacus L]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8323683
Azelaic acid--a new topical treatment for acne. 1993 Drug Ther Bull pmid:8344141
Gatti S and Nini G Treatment of reticulate acropigmentation of Kitamura with azelaic acid. 1993 J. Am. Acad. Dermatol. pmid:8408814
Brasch J and Christophers E Azelaic acid has antimycotic properties in vitro. 1993 Dermatology (Basel) pmid:8435518
Rodríguez Prieto MA et al. Treatment of lentigo maligna with azelaic acid. 1993 Int. J. Dermatol. pmid:8505164
U-Taniguchi Y et al. Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. 1995 Oncol. Res. pmid:8555652
Addo-Boadu K et al. Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. 1996 Cancer Lett. pmid:8635147
Azelaic acid-a new topical drug for acne. 1996 Med Lett Drugs Ther pmid:8637482
Gibson JR Rationale for the development of new topical treatments for acne vulgaris. 1996 Cutis pmid:8654127
Graupe K et al. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. 1996 Cutis pmid:8654128
Breathnach AS Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. 1996 Cutis pmid:8654129
Lowe NJ New approaches in dermatology: a clinical profile of azelaic acid. 1996 Cutis pmid:8654130
Oh CW and Myung KB An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. 1996 J. Dermatol. pmid:8935627
Nazzaro-Porro M et al. A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. 1996 Clin. Exp. Dermatol. pmid:8959915
Mackrides PS and Shaughnessy AF Azelaic acid therapy for acne. 1996 Am Fam Physician pmid:8961845
Rodriguez-Vicente J et al. Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. 1996 Pigment Cell Res. pmid:9125756