Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Parodi A et al. | Treatment of rosacea. | 2011 | Ann Dermatol Venereol | pmid:22183101 |
Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
pmid:22226365 | ||||
Verma P and Pathak K | Therapeutic and cosmeceutical potential of ethosomes: An overview. | 2010 | J Adv Pharm Technol Res | pmid:22247858 |
pmid:22268388 | ||||
Park SY et al. | The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus. | 2012 | Ann Dermatol | pmid:22363153 |
Wang HW et al. | Insight into the molecular evolution of non-specific lipid transfer proteins via comparative analysis between rice and sorghum. | 2012 | DNA Res. | pmid:22368182 |
Chaturvedi R et al. | An abietane diterpenoid is a potent activator of systemic acquired resistance. | 2012 | Plant J. | pmid:22385469 |
Hsieh PW et al. | The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin. | 2012 | Eur J Pharm Biopharm | pmid:22469554 |
Aytekin M et al. | Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery. | 2013 | Drug Dev Ind Pharm | pmid:22480294 |
Estronca LM et al. | Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model. | 2012 | PLoS ONE | pmid:22514671 |
Garelnabi M et al. | Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples. | 2010 | N Am J Med Sci | pmid:22558586 |
Fabbrocini G et al. | Skin needling to enhance depigmenting serum penetration in the treatment of melasma. | 2011 | Plast Surg Int | pmid:22567235 |
Reinholz M et al. | Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. | 2012 | Ann Dermatol | pmid:22577261 |
Lorenc-Kukula K et al. | Biochemical and Molecular-Genetic Characterization of SFD1's Involvement in Lipid Metabolism and Defense Signaling. | 2012 | Front Plant Sci | pmid:22645576 |
Cuevas P et al. | Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea. | 2011 | BMJ Case Rep | pmid:22675033 |
Zhao H et al. | Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome. | 2012 | Evid Based Complement Alternat Med | pmid:22675387 |
Rozema E et al. | Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22675394 |
pmid:22747347 | ||||
Sarkar R et al. | Newer and upcoming therapies for melasma. | 2012 Jul-Aug | Indian J Dermatol Venereol Leprol | pmid:22772611 |
Bhatia ND and Del Rosso JQ | Optimal management of papulopustular rosacea: rationale for combination therapy. | 2012 | J Drugs Dermatol | pmid:22777226 |
Wang H et al. | [Chemical constituents of Halenia elliptica]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22779176 |
Zoeller M et al. | Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid. | 2012 | Plant Physiol. | pmid:22822212 |
pmid:22849351 | ||||
Zaffaroni N et al. | Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. | 1990 Nov-Dec | Anticancer Res. | pmid:2285231 |
Maes M et al. | Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression. | 2013 | J Affect Disord | pmid:22898471 |
Simonart T | Newer approaches to the treatment of acne vulgaris. | 2012 | Am J Clin Dermatol | pmid:22920095 |
Wilkerson MG and Wilkin JK | Azelaic acid esters do not depigment pigmented guinea pig skin. | 1990 | Arch Dermatol | pmid:2301969 |
Matsubara T et al. | Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. | 2012 | Cell Metab. | pmid:23140643 |
Pazoki-Toroudi H et al. | Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia. | 2012 Sep-Oct | Skinmed | pmid:23163069 |
Fallen RS and Gooderham M | Rosacea: update on management and emerging therapies. | 2012 | Skin Therapy Lett. | pmid:23223767 |
Briganti S et al. | Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. | 2013 | Exp. Dermatol. | pmid:23278893 |
Muthulakshmi S and Saravanan R | Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice. | 2013 | Mol. Cell. Biochem. | pmid:23361364 |
Chauhan N and Ellis DA | Rosacea: pathophysiology and management principles. | 2013 | Facial Plast Surg Clin North Am | pmid:23369595 |
Shalita AR et al. | Inflammatory acne management with a novel prescription dietary supplement. | 2012 | J Drugs Dermatol | pmid:23377512 |
Muthulakshmi S and Saravanan R | Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice. | 2013 | Biochimie | pmid:23402910 |
Bayerl C | [Acne therapy in pregnancy]. | 2013 | Hautarzt | pmid:23430167 |
Quigley EA and Halpern AC | Microinvasive melanoma: cutaneous pharmacotherapeutic approaches. | 2013 | Am J Clin Dermatol | pmid:23479385 |
Reis CP et al. | Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. | 2014 | Drug Dev Ind Pharm | pmid:23480566 |
Jackson JM et al. | Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea. | 2013 | J Drugs Dermatol | pmid:23545911 |
Yu K et al. | A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity. | 2013 | Cell Rep | pmid:23602565 |
Woolery-Lloyd HC et al. | Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. | 2013 | J Drugs Dermatol | pmid:23652891 |
Reis CP et al. | Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles. | 2013 | Microsc. Microanal. | pmid:23673203 |
Schöfer H | [Topical therapy of rosacea]. | 2013 | Hautarzt | pmid:23780475 |
Melnik BC and Schmitz G | Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? | 2013 | Exp. Dermatol. | pmid:23800068 |
Coda AB et al. | Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. | 2013 | J. Am. Acad. Dermatol. | pmid:23871720 |
Alzweiri M et al. | Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker. | 2013 | J Sep Sci | pmid:23893928 |
von Schönfels W et al. | Metabolic signature of electrosurgical liver dissection. | 2013 | PLoS ONE | pmid:24058442 |
Han S et al. | Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS. | 2014 | AAPS PharmSciTech | pmid:24166667 |
Zheng P et al. | A novel urinary metabolite signature for diagnosing major depressive disorder. | 2013 | J. Proteome Res. | pmid:24224655 |
Han S et al. | Application of HPLC with ELSD detection for the assessment of azelaic acid impurities in liposomal formulation. | 2013 | ScientificWorldJournal | pmid:24228008 |
Gołębiowski M et al. | Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. | 2014 | J. Appl. Microbiol. | pmid:24238211 |
Sieber MA and Hegel JK | Azelaic acid: Properties and mode of action. | 2014 | Skin Pharmacol Physiol | pmid:24280644 |
Vargas-Diez E et al. | Azelaic acid in the treatment of acne in adult females: case reports. | 2014 | Skin Pharmacol Physiol | pmid:24280645 |
Mayer-da Silva A et al. | Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. | 1987 | Acta Derm. Venereol. | pmid:2438874 |
Draelos ZD et al. | Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study. | 2013 | Cutis | pmid:24416747 |
Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
pmid:24591049 | ||||
Shariff A et al. | Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. | 2014 | Dermatol. Online J. | pmid:24656277 |
Wang C et al. | Free radicals mediate systemic acquired resistance. | 2014 | Cell Rep | pmid:24726369 |
Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
Del Rosso JQ et al. | Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 5: a guide on the management of rosacea. | 2014 | Cutis | pmid:24738094 |
Mayer-da-Silva A et al. | Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2475995 |
Ganzetti G et al. | Rosacea: could topical azelaic acid and oral tetracyclines modify videocapillaroscopic pattern? | 2014 Mar-Apr | Skinmed | pmid:24933858 |
Mingrone G et al. | Preliminary studies of a dicarboxylic acid as an energy substrate in man. | 1989 May-Jun | JPEN J Parenter Enteral Nutr | pmid:2503641 |
Wittek F et al. | Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. | 2014 | J. Exp. Bot. | pmid:25114016 |
Töpert M et al. | Pharmacology and toxicology of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528255 |
Cunliffe WJ and Holland KT | Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528256 |
Katsambas A et al. | Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528257 |
Cavicchini S and Caputo R | Long-term treatment of acne with 20% azelaic acid cream. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528258 |
Hjorth N and Graupe K | Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528259 |
Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
Nazzaro-Porro M et al. | [Azelaic acid in the treatment of acne]. | 1989 | G Ital Dermatol Venereol | pmid:2530163 |
Zina G | [Azelaic acid: an innovation in the treatment of acne. Introduction and history]. | 1989 | G Ital Dermatol Venereol | pmid:2534549 |
Passi S et al. | [Mechanism of azelaic acid action in acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534550 |
Cavicchini S and Caputo R | [National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534551 |
Giannotti B | [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534552 |
Colonna SM | [Validity of azelaic acid in the therapy of acne. Long-term clinical results]. | 1989 | G Ital Dermatol Venereol | pmid:2534553 |
Troccoli T et al. | [Topical therapeutic action of azelaic acid in polymorphous acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534554 |
pmid:25399481 | ||||
pmid:25575741 | ||||
pmid:25607706 | ||||
Del Rosso JQ and Kircik LH | Update on the management of rosacea: a status report on the current role and new horizons with topical azelaic acid. | 2014 | J Drugs Dermatol | pmid:25607798 |
pmid:25669434 | ||||
pmid:25804639 | ||||
Karimi AA et al. | Improvement of tissue survival of skin flaps by 5α-reductase inhibitors: possible involvement of nitric oxide and inducible nitric oxide synthase. | 2015 | Iran. Biomed. J. | pmid:25864816 |
pmid:25890456 | ||||
van Zuuren EJ et al. | Interventions for rosacea. | 2015 | Cochrane Database Syst Rev | pmid:25919144 |
pmid:26002568 | ||||
pmid:26143424 | ||||
pmid:26244354 | ||||
Gordy JW et al. | Comparative Effectiveness of Potential Elicitors of Plant Resistance against Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) in Four Crop Plants. | 2015 | PLoS ONE | pmid:26332833 |
pmid:26355614 | ||||
Gupta G et al. | Ivermectin 1% cream for rosacea. | 2015 Jul-Aug | Skin Therapy Lett. | pmid:26382711 |
pmid:26396117 | ||||
Ely H | Dermatologic therapies you've probably never heard of. | 1989 | Dermatol Clin | pmid:2646047 |
pmid:26472098 | ||||
pmid:26563877 | ||||
Breathnach AC et al. | Azelaic acid therapy in disorders of pigmentation. | 1989 Apr-Jun | Clin. Dermatol. | pmid:2667735 |
Breathnach AS et al. | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2672685 |