Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
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pmid:29040817 | ||||
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Schallreuter KU and Wood JM | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. | 1987 | Cancer Lett. | pmid:3652030 |
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McLean DI and Peter KK | Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. | 1986 | Br. J. Dermatol. | pmid:3718862 |
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Robins EJ et al. | Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. | 1985 | J. Invest. Dermatol. | pmid:4031537 |
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Solo AJ and Gardner JO | Agents for alkylating steroid hormone receptors. 3. Omega-substituted esters of 17-alpha-hydroxyprogesterone. | 1971 | J Pharm Sci | pmid:5115254 |
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Nazzaro-Porro M et al. | Beneficial effect of 15% azelaic acid cream on acne vulgaris. | 1983 | Br. J. Dermatol. | pmid:6222755 |
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[Advances in pigment studies]. | 1983 | Hautarzt | pmid:6678891 | |
Willshaw HE and Rubinstein K | Azelaic acid in the treatment of ocular and adnexal malignant melanoma. | 1983 | Br J Ophthalmol | pmid:6848136 |
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Grimes PE | Melasma. Etiologic and therapeutic considerations. | 1995 | Arch Dermatol | pmid:7492140 |
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Gatti S and Nini G | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. | 1993 | J. Am. Acad. Dermatol. | pmid:8408814 |
Brasch J and Christophers E | Azelaic acid has antimycotic properties in vitro. | 1993 | Dermatology (Basel) | pmid:8435518 |
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Addo-Boadu K et al. | Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. | 1996 | Cancer Lett. | pmid:8635147 |
Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
Gibson JR | Rationale for the development of new topical treatments for acne vulgaris. | 1996 | Cutis | pmid:8654127 |
Graupe K et al. | Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. | 1996 | Cutis | pmid:8654128 |
Breathnach AS | Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. | 1996 | Cutis | pmid:8654129 |
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Nazzaro-Porro M et al. | A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. | 1996 | Clin. Exp. Dermatol. | pmid:8959915 |
Mackrides PS and Shaughnessy AF | Azelaic acid therapy for acne. | 1996 | Am Fam Physician | pmid:8961845 |
Rodriguez-Vicente J et al. | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. | 1996 | Pigment Cell Res. | pmid:9125756 |