Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Gollnick H and Schramm M | Topical therapy in acne. | 1998 | J Eur Acad Dermatol Venereol | pmid:9891903 |
Kakita LS and Lowe NJ | Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. | 1998 Sep-Oct | Clin Ther | pmid:9829447 |
Lowe NJ et al. | Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. | 1998 Sep-Oct | Clin Ther | pmid:9829446 |
Spellman MC and Pincus SH | Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. | 1998 Jul-Aug | Clin Ther | pmid:9737831 |
Gatti R et al. | Analysis of aliphatic dicarboxylic acids in pharmaceuticals and cosmetics by liquid chromatography (HPLC) with fluorescence detection. | 1995 | J Pharm Biomed Anal | pmid:9696574 |
Gollnick H and Schramm M | Topical drug treatment in acne. | 1998 | Dermatology (Basel) | pmid:9557245 |
Usatine RP et al. | Acne vulgaris: a treatment update. | 1998 | Hosp Pract (1995) | pmid:9484299 |
Rodriguez-Vicente J et al. | The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. | 1998 | Cancer | pmid:9452267 |
Gibson JR | Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. | 1997 | Dermatol Nurs | pmid:9392765 |
Parsons PG et al. | Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells. | 1997 | Biochem. Pharmacol. | pmid:9264325 |
Jansen T and Plewig G | Advances and perspectives in acne therapy. | 1997 | Eur. J. Med. Res. | pmid:9262484 |
Rodriguez-Vicente J et al. | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. | 1996 | Pigment Cell Res. | pmid:9125756 |
Mackrides PS and Shaughnessy AF | Azelaic acid therapy for acne. | 1996 | Am Fam Physician | pmid:8961845 |
Nazzaro-Porro M et al. | A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. | 1996 | Clin. Exp. Dermatol. | pmid:8959915 |
Oh CW and Myung KB | An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. | 1996 | J. Dermatol. | pmid:8935627 |
Lowe NJ | New approaches in dermatology: a clinical profile of azelaic acid. | 1996 | Cutis | pmid:8654130 |
Breathnach AS | Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. | 1996 | Cutis | pmid:8654129 |
Graupe K et al. | Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. | 1996 | Cutis | pmid:8654128 |
Gibson JR | Rationale for the development of new topical treatments for acne vulgaris. | 1996 | Cutis | pmid:8654127 |
Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
Addo-Boadu K et al. | Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. | 1996 | Cancer Lett. | pmid:8635147 |
U-Taniguchi Y et al. | Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. | 1995 | Oncol. Res. | pmid:8555652 |
RodrÃguez Prieto MA et al. | Treatment of lentigo maligna with azelaic acid. | 1993 | Int. J. Dermatol. | pmid:8505164 |
Brasch J and Christophers E | Azelaic acid has antimycotic properties in vitro. | 1993 | Dermatology (Basel) | pmid:8435518 |
Gatti S and Nini G | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. | 1993 | J. Am. Acad. Dermatol. | pmid:8408814 |
Azelaic acid--a new topical treatment for acne. | 1993 | Drug Ther Bull | pmid:8344141 | |
Zhang EJ et al. | [Chemical constituents from the bark of Hibiscus syriacus L]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8323683 |
Bojar RA et al. | Follicular concentrations of azelaic acid after a single topical application. | 1993 | Br. J. Dermatol. | pmid:8217752 |
Pattarino F et al. | Topical delivery systems for azelaic acid: effect of the suspended drug in microemulsion. | 1994 | Pharmazie | pmid:8140138 |
Banerjee S et al. | Proxyl nitroxide of lithocholic acid: a potential spin probe for model membranes. | 1993 | Bioorg. Med. Chem. | pmid:8081864 |
Ferioli V et al. | Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization. | 1994 | Farmaco | pmid:8074784 |
Banerjee S et al. | 2'-(3 alpha-Benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'- dihydrooxazoline-N-oxyl as a potential spin probe for model membranes. | 1994 | Steroids | pmid:7940616 |
Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
Nguyen QH and Bui TP | Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. | 1995 | Int. J. Dermatol. | pmid:7737781 |
Grammatico P et al. | Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. | 1993 | Mutat. Res. | pmid:7685492 |
Lemic-Stojcevic L et al. | Effect of azelaic acid on melanoma cells in culture. | 1995 | Exp. Dermatol. | pmid:7640879 |
Grimes PE | Melasma. Etiologic and therapeutic considerations. | 1995 | Arch Dermatol | pmid:7492140 |
Palassis J | The sampling and determination of azelaic acid in air. | 1978 | Am Ind Hyg Assoc J | pmid:727120 |
Maru U et al. | [In vitro diffusion and skin penetration of azelaic preparations: study of correlations]. | 1982 May-Jun | J Pharm Belg | pmid:7131228 |
Willshaw HE and Rubinstein K | Azelaic acid in the treatment of ocular and adnexal malignant melanoma. | 1983 | Br J Ophthalmol | pmid:6848136 |
[Advances in pigment studies]. | 1983 | Hautarzt | pmid:6678891 | |
Passi S et al. | Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631243 |
Mingrone G et al. | Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. | 1984 | Exp Pathol | pmid:6539234 |
Breathnach AS et al. | Azelaic acid. | 1984 | Br. J. Dermatol. | pmid:6234914 |
Marsden JR and Shuster S | The effect of azelaic acid on acne. | 1983 | Br. J. Dermatol. | pmid:6228247 |
Nazzaro-Porro M et al. | Beneficial effect of 15% azelaic acid cream on acne vulgaris. | 1983 | Br. J. Dermatol. | pmid:6222755 |
Nazzaro-Porro M et al. | Effect of azelaic acid on human malignant melanoma. | 1980 | Lancet | pmid:6103442 |
Solo AJ and Gardner JO | Agents for alkylating steroid hormone receptors. 3. Omega-substituted esters of 17-alpha-hydroxyprogesterone. | 1971 | J Pharm Sci | pmid:5115254 |
Polis BD et al. | Studies on PGBx, a polymeric derivative of prostaglandin B1: I. Synthesis and purification of PGBx. | 1979 | Physiol. Chem. Phys. | pmid:482383 |
Dousset N and Douste-Blazy L | [Azelaic acid transformation into monocarboxylic fatty acids in vivo in the rat]. | 1973 | Biochimie | pmid:4793585 |