Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nazzaro-Porro M et al. | The depigmenting effect of azelaic acid. | 1990 | Arch Dermatol | pmid:2073286 |
Elewski BE et al. | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. | 2003 | Arch Dermatol | pmid:14623704 |
Thiboutot D | New treatments and therapeutic strategies for acne. | 2000 | Arch Fam Med | pmid:10693736 |
Akman A et al. | Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. | 2007 | Arch. Dermatol. Res. | pmid:17710426 |
Schallreuter KU and Wood JW | A possible mechanism of action for azelaic acid in the human epidermis. | 1990 | Arch. Dermatol. Res. | pmid:2114832 |
Akamatsu H et al. | Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. | 1991 | Arch. Dermatol. Res. | pmid:1867478 |
Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |
Goodman G | Managing acne vulgaris effectively. | 2006 | Aust Fam Physician | pmid:16969442 |
Auld J | Topical therapy of acne. | 1986 | Australas. J. Dermatol. | pmid:2957990 |
Brinkworth RI et al. | Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2018518 |