Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Acne Keloid D000153 1 associated lipids
Alopecia Areata D000506 6 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Drug Eruptions D003875 30 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Erythema D004890 22 associated lipids
Facial Dermatoses D005148 7 associated lipids
Heart Failure D006333 36 associated lipids
Inflammation D007249 119 associated lipids
Keratosis D007642 9 associated lipids
Leukemia D007938 74 associated lipids
Melanoma D008545 69 associated lipids
Melanosis D008548 4 associated lipids
Pain D010146 64 associated lipids
Pituitary Apoplexy D010899 1 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Psoriasis D011565 47 associated lipids
Rhinophyma D012224 1 associated lipids
Rosacea D012393 13 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Hutchinson's Melanotic Freckle D018327 2 associated lipids
Dermatitis, Perioral D019557 4 associated lipids
Pituitary ACTH Hypersecretion D047748 1 associated lipids
Disease Resistance D060467 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

Download all related citations
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Authors Title Published Journal PubMed Link
Iraji F et al. Efficacy of 15% azelaic acid in psoriasis vulgaris: a randomized, controlled clinical trial. 2010 J Drugs Dermatol pmid:20684146
Kircik LH Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study. 2011 J Drugs Dermatol pmid:21637899
Wheeland RG and Dhawan S Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system. 2011 J Drugs Dermatol pmid:21637900
Que SK and Bergstrom KG Hyperpigmentation: old problem, new therapies. 2009 J Drugs Dermatol pmid:19746682
Thiboutot DM et al. A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy. 2009 J Drugs Dermatol pmid:19588640
Ziel K et al. Cumulative irritation potential of metronidazole gel compared to azelaic acid gel after repeated applications to healthy skin. 2005 Nov-Dec J Drugs Dermatol pmid:16302558
Fleischer A and Suephy C The face and mind evaluation study: an examination of the efficacy of rosacea treatment using physician ratings and patients' self-reported quality of life. 2005 Sep-Oct J Drugs Dermatol pmid:16167417
Thiboutot DM et al. Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea. 2008 J Drugs Dermatol pmid:18561584
Bhatia ND and Del Rosso JQ Optimal management of papulopustular rosacea: rationale for combination therapy. 2012 J Drugs Dermatol pmid:22777226
Woolery-Lloyd HC et al. Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. 2013 J Drugs Dermatol pmid:23652891