Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
Banerjee S et al. | Proxyl nitroxide of lithocholic acid: a potential spin probe for model membranes. | 1993 | Bioorg. Med. Chem. | pmid:8081864 |
Bojar RA et al. | Follicular concentrations of azelaic acid after a single topical application. | 1993 | Br. J. Dermatol. | pmid:8217752 |
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Brasch J and Christophers E | Azelaic acid has antimycotic properties in vitro. | 1993 | Dermatology (Basel) | pmid:8435518 |
Azelaic acid--a new topical treatment for acne. | 1993 | Drug Ther Bull | pmid:8344141 | |
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Duteil L and Ortonne JP | Colorimetric assessment of the effects of azelaic acid on light-induced skin pigmentation. | 1992 | Photodermatol Photoimmunol Photomed | pmid:1489719 |
Maple PA et al. | Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. | 1992 | J. Antimicrob. Chemother. | pmid:1506349 |
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Passi S et al. | The oxyradical-scavenging activity of azelaic acid in biological systems. | 1991 | Free Radic. Res. Commun. | pmid:1769610 |
Akamatsu H et al. | Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. | 1991 | Arch. Dermatol. Res. | pmid:1867478 |
Fitton A and Goa KL | Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. | 1991 | Drugs | pmid:1712709 |
Bojar RA et al. | The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. | 1991 | J. Antimicrob. Chemother. | pmid:1726169 |
[Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991]. | 1991 | Hautarzt | pmid:1674505 | |
Bertuzzi A et al. | Pharmacokinetic analysis of azelaic acid disodium salt. A proposed substrate for total parenteral nutrition. | 1991 | Clin Pharmacokinet | pmid:1908756 |
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Zaffaroni N et al. | Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. | 1990 Nov-Dec | Anticancer Res. | pmid:2285231 |
Tacchino RM et al. | Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry. | 1990 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:2112625 |
Angius AG et al. | [Evaluation of the anti-comedo effect of azelaic acid using the technique of horny layer biopsy and scanning electron microscopy]. | 1990 | G Ital Dermatol Venereol | pmid:2149715 |
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Chagnaud JL et al. | Monoclonal anti-conjugated azelaic acid antibody production: application to multiple sclerosis. | 1990 | Neuroreport | pmid:2129868 |
Wilkerson MG and Wilkin JK | Azelaic acid esters do not depigment pigmented guinea pig skin. | 1990 | Arch Dermatol | pmid:2301969 |
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Cavicchini S and Caputo R | [National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534551 |
Breathnach AS et al. | Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2925320 |
Giannotti B | [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534552 |
Colonna SM | [Validity of azelaic acid in the therapy of acne. Long-term clinical results]. | 1989 | G Ital Dermatol Venereol | pmid:2534553 |
Troccoli T et al. | [Topical therapeutic action of azelaic acid in polymorphous acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534554 |
Breathnach AS et al. | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2672685 |
Ely H | Dermatologic therapies you've probably never heard of. | 1989 | Dermatol Clin | pmid:2646047 |
Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
Mayer-da-Silva A et al. | Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2475995 |
Töpert M et al. | Pharmacology and toxicology of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528255 |
Cunliffe WJ and Holland KT | Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528256 |
Katsambas A et al. | Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528257 |
Cavicchini S and Caputo R | Long-term treatment of acne with 20% azelaic acid cream. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528258 |
Hjorth N and Graupe K | Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528259 |
Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
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Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773613 | |
Nazzaro-Porro M et al. | Ten years' experience of treating lentigo maligna with topical azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773614 |
Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
Flamigni F et al. | Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. | 1989 | Biochem. J. | pmid:2719637 |
Landthaler M et al. | [Lentigo of the glans penis]. | 1989 | Hautarzt | pmid:2732050 |
Daverat P et al. | Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. | 1989 | J. Neuroimmunol. | pmid:2925840 |
Jorand JP et al. | The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. | 1989 | Horm. Metab. Res. | pmid:2807145 |
Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
Mingrone G et al. | Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. | 1988 | Q J Exp Physiol | pmid:3164112 |
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Sowden J et al. | Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid. | 1988 | Clin. Exp. Dermatol. | pmid:3256454 |
Stamatiadis D et al. | Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. | 1988 | Br. J. Dermatol. | pmid:3207614 |
Mayer-da Silva A et al. | Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. | 1987 | Acta Derm. Venereol. | pmid:2438874 |
Nazzaro-Porro M | Azelaic acid. | 1987 | J. Am. Acad. Dermatol. | pmid:2963038 |
Azelaic acid in lentigo maligna. | 1987 | Br. J. Dermatol. | pmid:3580294 | |
Grosshans E and Chartier C | [Therapeutic depigmentation agents]. | 1987 | Schweiz. Rundsch. Med. Prax. | pmid:3671942 |
Schallreuter KU and Wood JM | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. | 1987 | Cancer Lett. | pmid:3652030 |
Hu F et al. | Effects of dicarboxylic acids on normal and malignant melanocytes in culture. | 1986 | Br. J. Dermatol. | pmid:3942687 |
Leeming JP et al. | The in vitro antimicrobial effect of azelaic acid. | 1986 | Br. J. Dermatol. | pmid:2947607 |
Rocchiccioli F et al. | Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. | 1986 | Pediatr. Res. | pmid:3945517 |
Auld J | Topical therapy of acne. | 1986 | Australas. J. Dermatol. | pmid:2957990 |
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Robins EJ et al. | Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1986 | J. Invest. Dermatol. | pmid:3734479 |
Ortonne JP | [Depigmenting chemical agents]. | 1986 | Ann Dermatol Venereol | pmid:3800227 |
Ward BJ et al. | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. | 1986 | J. Invest. Dermatol. | pmid:3745962 |
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Robins EJ et al. | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. | 1985 | Br. J. Dermatol. | pmid:4096883 |
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Mingrone G et al. | Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. | 1984 | Exp Pathol | pmid:6539234 |
Passi S et al. | Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631243 |
Nazzaro-Porro M et al. | Beneficial effect of 15% azelaic acid cream on acne vulgaris. | 1983 | Br. J. Dermatol. | pmid:6222755 |
Marsden JR and Shuster S | The effect of azelaic acid on acne. | 1983 | Br. J. Dermatol. | pmid:6228247 |
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[Advances in pigment studies]. | 1983 | Hautarzt | pmid:6678891 | |
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