Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Czernielewski J and Liu Y | Comparison of 15% azelaic acid gel and 0.75% metronidazole gel for the topical treatment of papulopustular rosacea. | 2004 | Arch Dermatol | pmid:15492198 |
Liu RH et al. | Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. | 2006 | Arch Dermatol | pmid:16924055 |
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Akman A et al. | Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. | 2007 | Arch. Dermatol. Res. | pmid:17710426 |
Schallreuter KU and Wood JW | A possible mechanism of action for azelaic acid in the human epidermis. | 1990 | Arch. Dermatol. Res. | pmid:2114832 |
Akamatsu H et al. | Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. | 1991 | Arch. Dermatol. Res. | pmid:1867478 |
Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |
Goodman G | Managing acne vulgaris effectively. | 2006 | Aust Fam Physician | pmid:16969442 |
Auld J | Topical therapy of acne. | 1986 | Australas. J. Dermatol. | pmid:2957990 |
Brinkworth RI et al. | Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2018518 |
Flamigni F et al. | Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. | 1989 | Biochem. J. | pmid:2719637 |
Picardo M et al. | Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts. | 1985 | Biochem. Pharmacol. | pmid:4004885 |
Parsons PG et al. | Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells. | 1997 | Biochem. Pharmacol. | pmid:9264325 |
Muthulakshmi S and Saravanan R | Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice. | 2013 | Biochimie | pmid:23402910 |
Dousset N and Douste-Blazy L | [Azelaic acid transformation into monocarboxylic fatty acids in vivo in the rat]. | 1973 | Biochimie | pmid:4793585 |
Devereux M et al. | Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 | Bioinorg Chem Appl | pmid:17497019 |
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Cuevas P et al. | Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea. | 2011 | BMJ Case Rep | pmid:22675033 |
Purdy S and de Berker D | Acne vulgaris. | 2011 | BMJ Clin Evid | pmid:21477388 |
Purdy S and Deberker D | Acne vulgaris. | 2008 | BMJ Clin Evid | pmid:19450306 |
Willshaw HE and Rubinstein K | Azelaic acid in the treatment of ocular and adnexal malignant melanoma. | 1983 | Br J Ophthalmol | pmid:6848136 |
Hu F et al. | Effects of dicarboxylic acids on normal and malignant melanocytes in culture. | 1986 | Br. J. Dermatol. | pmid:3942687 |
Jansen T | Azelaic acid as a new treatment for perioral dermatitis: results from an open study. | 2004 | Br. J. Dermatol. | pmid:15491447 |
Leeming JP et al. | The in vitro antimicrobial effect of azelaic acid. | 1986 | Br. J. Dermatol. | pmid:2947607 |
Gassmueller H et al. | Azelaic acid and sebum excretion rate. | 1985 | Br. J. Dermatol. | pmid:2937439 |
Bladon PT et al. | Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. | 1986 | Br. J. Dermatol. | pmid:2938615 |
McLean DI and Peter KK | Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. | 1986 | Br. J. Dermatol. | pmid:3718862 |
Azelaic acid in lentigo maligna. | 1987 | Br. J. Dermatol. | pmid:3580294 | |
Stamatiadis D et al. | Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. | 1988 | Br. J. Dermatol. | pmid:3207614 |
Robins EJ et al. | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. | 1985 | Br. J. Dermatol. | pmid:4096883 |
Breathnach AS et al. | Azelaic acid. | 1984 | Br. J. Dermatol. | pmid:6234914 |
Nazzaro-Porro M et al. | Beneficial effect of 15% azelaic acid cream on acne vulgaris. | 1983 | Br. J. Dermatol. | pmid:6222755 |
Marsden JR and Shuster S | The effect of azelaic acid on acne. | 1983 | Br. J. Dermatol. | pmid:6228247 |
Bojar RA et al. | Follicular concentrations of azelaic acid after a single topical application. | 1993 | Br. J. Dermatol. | pmid:8217752 |
Malaisse WJ et al. | Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets. | 2000 | Br. J. Nutr. | pmid:11177188 |
Rodriguez-Vicente J et al. | The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. | 1998 | Cancer | pmid:9452267 |
Schallreuter KU and Wood JM | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. | 1987 | Cancer Lett. | pmid:3652030 |
Addo-Boadu K et al. | Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. | 1996 | Cancer Lett. | pmid:8635147 |
Lim GH et al. | Plasmodesmata Localizing Proteins Regulate Transport and Signaling during Systemic Acquired Immunity in Plants. | 2016 | Cell Host Microbe | pmid:27078071 |
Matsubara T et al. | Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. | 2012 | Cell Metab. | pmid:23140643 |
Wang C et al. | Free radicals mediate systemic acquired resistance. | 2014 | Cell Rep | pmid:24726369 |
Yu K et al. | A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity. | 2013 | Cell Rep | pmid:23602565 |
Li H et al. | Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 | Chem. Res. Toxicol. | pmid:15962942 |
Hojo Y et al. | Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. | 2002 | Circ. Res. | pmid:12386148 |
Kuster GM et al. | Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. | 2005 | Circulation | pmid:15723974 |