Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zina G | [Azelaic acid: an innovation in the treatment of acne. Introduction and history]. | 1989 | G Ital Dermatol Venereol | pmid:2534549 |
| Passi S et al. | [Mechanism of azelaic acid action in acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534550 |
| Cavicchini S and Caputo R | [National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534551 |
| Breathnach AS et al. | Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2925320 |
| Giannotti B | [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534552 |
| Colonna SM | [Validity of azelaic acid in the therapy of acne. Long-term clinical results]. | 1989 | G Ital Dermatol Venereol | pmid:2534553 |
| Troccoli T et al. | [Topical therapeutic action of azelaic acid in polymorphous acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534554 |
| Breathnach AS et al. | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2672685 |
| Ely H | Dermatologic therapies you've probably never heard of. | 1989 | Dermatol Clin | pmid:2646047 |
| Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
| Mayer-da-Silva A et al. | Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2475995 |
| Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
| Nazzaro-Porro M et al. | [Azelaic acid in the treatment of acne]. | 1989 | G Ital Dermatol Venereol | pmid:2530163 |
| Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773613 | |
| Nazzaro-Porro M et al. | Ten years' experience of treating lentigo maligna with topical azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773614 |
| Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
| Flamigni F et al. | Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. | 1989 | Biochem. J. | pmid:2719637 |
| Landthaler M et al. | [Lentigo of the glans penis]. | 1989 | Hautarzt | pmid:2732050 |
| Daverat P et al. | Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. | 1989 | J. Neuroimmunol. | pmid:2925840 |
| Jorand JP et al. | The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. | 1989 | Horm. Metab. Res. | pmid:2807145 |
| Breathnach AC et al. | Azelaic acid therapy in disorders of pigmentation. | 1989 Apr-Jun | Clin. Dermatol. | pmid:2667735 |
| Rigoni C et al. | [Use of a cream based on 20% azelaic acid in the treatment of melasma]. | 1989 Jan-Feb | G Ital Dermatol Venereol | pmid:2767714 |
| Mingrone G et al. | Preliminary studies of a dicarboxylic acid as an energy substrate in man. | 1989 May-Jun | JPEN J Parenter Enteral Nutr | pmid:2503641 |
| Angius AG et al. | [Evaluation of the anti-comedo effect of azelaic acid using the technique of horny layer biopsy and scanning electron microscopy]. | 1990 | G Ital Dermatol Venereol | pmid:2149715 |
| Nazzaro-Porro M et al. | The depigmenting effect of azelaic acid. | 1990 | Arch Dermatol | pmid:2073286 |
| Schallreuter KU and Wood JW | A possible mechanism of action for azelaic acid in the human epidermis. | 1990 | Arch. Dermatol. Res. | pmid:2114832 |
| Chagnaud JL et al. | Monoclonal anti-conjugated azelaic acid antibody production: application to multiple sclerosis. | 1990 | Neuroreport | pmid:2129868 |
| Wilkerson MG and Wilkin JK | Azelaic acid esters do not depigment pigmented guinea pig skin. | 1990 | Arch Dermatol | pmid:2301969 |
| Tacchino RM et al. | Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry. | 1990 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:2112625 |
| Zaffaroni N et al. | Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. | 1990 Nov-Dec | Anticancer Res. | pmid:2285231 |
| Brinkworth RI et al. | Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2018518 |
| Passi S et al. | The oxyradical-scavenging activity of azelaic acid in biological systems. | 1991 | Free Radic. Res. Commun. | pmid:1769610 |
| Akamatsu H et al. | Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. | 1991 | Arch. Dermatol. Res. | pmid:1867478 |
| Fitton A and Goa KL | Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. | 1991 | Drugs | pmid:1712709 |
| Bojar RA et al. | The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. | 1991 | J. Antimicrob. Chemother. | pmid:1726169 |
| [Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991]. | 1991 | Hautarzt | pmid:1674505 | |
| Bertuzzi A et al. | Pharmacokinetic analysis of azelaic acid disodium salt. A proposed substrate for total parenteral nutrition. | 1991 | Clin Pharmacokinet | pmid:1908756 |
| Gollnick H | [Azelaic acid for keratinization disorders?]. | 1991 | Med Monatsschr Pharm | pmid:1838401 |
| Baliña LM and Graupe K | The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. | 1991 | Int. J. Dermatol. | pmid:1816137 |
| Kameyama K et al. | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. An immunohistochemical and electron microscopic study. | 1992 | J. Am. Acad. Dermatol. | pmid:1613143 |
| Täuber U et al. | Percutaneous absorption of azelaic acid in humans. | 1992 | Exp. Dermatol. | pmid:1365318 |
| Duteil L and Ortonne JP | Colorimetric assessment of the effects of azelaic acid on light-induced skin pigmentation. | 1992 | Photodermatol Photoimmunol Photomed | pmid:1489719 |
| Maple PA et al. | Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. | 1992 | J. Antimicrob. Chemother. | pmid:1506349 |
| Banerjee S et al. | Proxyl nitroxide of lithocholic acid: a potential spin probe for model membranes. | 1993 | Bioorg. Med. Chem. | pmid:8081864 |
| Bojar RA et al. | Follicular concentrations of azelaic acid after a single topical application. | 1993 | Br. J. Dermatol. | pmid:8217752 |
| Zhang EJ et al. | [Chemical constituents from the bark of Hibiscus syriacus L]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8323683 |
| Brasch J and Christophers E | Azelaic acid has antimycotic properties in vitro. | 1993 | Dermatology (Basel) | pmid:8435518 |
| Azelaic acid--a new topical treatment for acne. | 1993 | Drug Ther Bull | pmid:8344141 | |
| Gatti S and Nini G | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. | 1993 | J. Am. Acad. Dermatol. | pmid:8408814 |
| Grammatico P et al. | Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. | 1993 | Mutat. Res. | pmid:7685492 |