Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Acne Keloid D000153 1 associated lipids
Alopecia Areata D000506 6 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Drug Eruptions D003875 30 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Erythema D004890 22 associated lipids
Facial Dermatoses D005148 7 associated lipids
Heart Failure D006333 36 associated lipids
Inflammation D007249 119 associated lipids
Keratosis D007642 9 associated lipids
Leukemia D007938 74 associated lipids
Melanoma D008545 69 associated lipids
Melanosis D008548 4 associated lipids
Pain D010146 64 associated lipids
Pituitary Apoplexy D010899 1 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Psoriasis D011565 47 associated lipids
Rhinophyma D012224 1 associated lipids
Rosacea D012393 13 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Hutchinson's Melanotic Freckle D018327 2 associated lipids
Dermatitis, Perioral D019557 4 associated lipids
Pituitary ACTH Hypersecretion D047748 1 associated lipids
Disease Resistance D060467 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

Download all related citations
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Authors Title Published Journal PubMed Link
Jansen T and Plewig G Advances and perspectives in acne therapy. 1997 Eur. J. Med. Res. pmid:9262484
Parsons PG et al. Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells. 1997 Biochem. Pharmacol. pmid:9264325
Gibson JR Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. 1997 Dermatol Nurs pmid:9392765
Rodriguez-Vicente J et al. The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. 1998 Cancer pmid:9452267
Usatine RP et al. Acne vulgaris: a treatment update. 1998 Hosp Pract (1995) pmid:9484299
Gollnick H and Schramm M Topical drug treatment in acne. 1998 Dermatology (Basel) pmid:9557245
Gatti R et al. Analysis of aliphatic dicarboxylic acids in pharmaceuticals and cosmetics by liquid chromatography (HPLC) with fluorescence detection. 1995 J Pharm Biomed Anal pmid:9696574
Spellman MC and Pincus SH Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. 1998 Jul-Aug Clin Ther pmid:9737831
Lowe NJ et al. Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. 1998 Sep-Oct Clin Ther pmid:9829446
Kakita LS and Lowe NJ Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. 1998 Sep-Oct Clin Ther pmid:9829447