Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Gibson JR | Rationale for the development of new topical treatments for acne vulgaris. | 1996 | Cutis | pmid:8654127 |
Nguyen QH and Bui TP | Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. | 1995 | Int. J. Dermatol. | pmid:7737781 |
U-Taniguchi Y et al. | Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. | 1995 | Oncol. Res. | pmid:8555652 |
Grimes PE | Melasma. Etiologic and therapeutic considerations. | 1995 | Arch Dermatol | pmid:7492140 |
Lemic-Stojcevic L et al. | Effect of azelaic acid on melanoma cells in culture. | 1995 | Exp. Dermatol. | pmid:7640879 |
Gatti R et al. | Analysis of aliphatic dicarboxylic acids in pharmaceuticals and cosmetics by liquid chromatography (HPLC) with fluorescence detection. | 1995 | J Pharm Biomed Anal | pmid:9696574 |
Banerjee S et al. | 2'-(3 alpha-Benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'- dihydrooxazoline-N-oxyl as a potential spin probe for model membranes. | 1994 | Steroids | pmid:7940616 |
Pattarino F et al. | Topical delivery systems for azelaic acid: effect of the suspended drug in microemulsion. | 1994 | Pharmazie | pmid:8140138 |
Ferioli V et al. | Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization. | 1994 | Farmaco | pmid:8074784 |
Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
Banerjee S et al. | Proxyl nitroxide of lithocholic acid: a potential spin probe for model membranes. | 1993 | Bioorg. Med. Chem. | pmid:8081864 |
Bojar RA et al. | Follicular concentrations of azelaic acid after a single topical application. | 1993 | Br. J. Dermatol. | pmid:8217752 |
Zhang EJ et al. | [Chemical constituents from the bark of Hibiscus syriacus L]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8323683 |
Brasch J and Christophers E | Azelaic acid has antimycotic properties in vitro. | 1993 | Dermatology (Basel) | pmid:8435518 |
Azelaic acid--a new topical treatment for acne. | 1993 | Drug Ther Bull | pmid:8344141 | |
Gatti S and Nini G | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. | 1993 | J. Am. Acad. Dermatol. | pmid:8408814 |
Grammatico P et al. | Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. | 1993 | Mutat. Res. | pmid:7685492 |
RodrÃguez Prieto MA et al. | Treatment of lentigo maligna with azelaic acid. | 1993 | Int. J. Dermatol. | pmid:8505164 |
Kameyama K et al. | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. An immunohistochemical and electron microscopic study. | 1992 | J. Am. Acad. Dermatol. | pmid:1613143 |
Täuber U et al. | Percutaneous absorption of azelaic acid in humans. | 1992 | Exp. Dermatol. | pmid:1365318 |
Duteil L and Ortonne JP | Colorimetric assessment of the effects of azelaic acid on light-induced skin pigmentation. | 1992 | Photodermatol Photoimmunol Photomed | pmid:1489719 |
Maple PA et al. | Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. | 1992 | J. Antimicrob. Chemother. | pmid:1506349 |
Brinkworth RI et al. | Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2018518 |
Passi S et al. | The oxyradical-scavenging activity of azelaic acid in biological systems. | 1991 | Free Radic. Res. Commun. | pmid:1769610 |
Akamatsu H et al. | Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. | 1991 | Arch. Dermatol. Res. | pmid:1867478 |
Fitton A and Goa KL | Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. | 1991 | Drugs | pmid:1712709 |
Bojar RA et al. | The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. | 1991 | J. Antimicrob. Chemother. | pmid:1726169 |
[Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991]. | 1991 | Hautarzt | pmid:1674505 | |
Bertuzzi A et al. | Pharmacokinetic analysis of azelaic acid disodium salt. A proposed substrate for total parenteral nutrition. | 1991 | Clin Pharmacokinet | pmid:1908756 |
Gollnick H | [Azelaic acid for keratinization disorders?]. | 1991 | Med Monatsschr Pharm | pmid:1838401 |
Baliña LM and Graupe K | The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. | 1991 | Int. J. Dermatol. | pmid:1816137 |
Zaffaroni N et al. | Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. | 1990 Nov-Dec | Anticancer Res. | pmid:2285231 |
Tacchino RM et al. | Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry. | 1990 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:2112625 |
Angius AG et al. | [Evaluation of the anti-comedo effect of azelaic acid using the technique of horny layer biopsy and scanning electron microscopy]. | 1990 | G Ital Dermatol Venereol | pmid:2149715 |
Nazzaro-Porro M et al. | The depigmenting effect of azelaic acid. | 1990 | Arch Dermatol | pmid:2073286 |
Schallreuter KU and Wood JW | A possible mechanism of action for azelaic acid in the human epidermis. | 1990 | Arch. Dermatol. Res. | pmid:2114832 |
Chagnaud JL et al. | Monoclonal anti-conjugated azelaic acid antibody production: application to multiple sclerosis. | 1990 | Neuroreport | pmid:2129868 |
Wilkerson MG and Wilkin JK | Azelaic acid esters do not depigment pigmented guinea pig skin. | 1990 | Arch Dermatol | pmid:2301969 |
Mingrone G et al. | Preliminary studies of a dicarboxylic acid as an energy substrate in man. | 1989 May-Jun | JPEN J Parenter Enteral Nutr | pmid:2503641 |
Rigoni C et al. | [Use of a cream based on 20% azelaic acid in the treatment of melasma]. | 1989 Jan-Feb | G Ital Dermatol Venereol | pmid:2767714 |
Breathnach AC et al. | Azelaic acid therapy in disorders of pigmentation. | 1989 Apr-Jun | Clin. Dermatol. | pmid:2667735 |
Breathnach AS et al. | Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2925320 |
Töpert M et al. | Pharmacology and toxicology of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528255 |
Cunliffe WJ and Holland KT | Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528256 |
Katsambas A et al. | Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528257 |
Cavicchini S and Caputo R | Long-term treatment of acne with 20% azelaic acid cream. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528258 |
Hjorth N and Graupe K | Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528259 |
Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
Nazzaro-Porro M et al. | [Azelaic acid in the treatment of acne]. | 1989 | G Ital Dermatol Venereol | pmid:2530163 |
Jorand JP et al. | The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. | 1989 | Horm. Metab. Res. | pmid:2807145 |