Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Breathnach AS et al. | Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2925320 |
| Breathnach AS et al. | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2672685 |
| Ely H | Dermatologic therapies you've probably never heard of. | 1989 | Dermatol Clin | pmid:2646047 |
| Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
| Mayer-da-Silva A et al. | Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2475995 |
| Töpert M et al. | Pharmacology and toxicology of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528255 |
| Cunliffe WJ and Holland KT | Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528256 |
| Katsambas A et al. | Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528257 |
| Cavicchini S and Caputo R | Long-term treatment of acne with 20% azelaic acid cream. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528258 |
| Hjorth N and Graupe K | Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528259 |
| Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
| Nazzaro-Porro M et al. | [Azelaic acid in the treatment of acne]. | 1989 | G Ital Dermatol Venereol | pmid:2530163 |
| Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773613 | |
| Nazzaro-Porro M et al. | Ten years' experience of treating lentigo maligna with topical azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773614 |
| Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
| Jorand JP et al. | The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. | 1989 | Horm. Metab. Res. | pmid:2807145 |
| Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
| Mingrone G et al. | Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. | 1988 | Q J Exp Physiol | pmid:3164112 |
| Piquero MartÃn J et al. | [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. | 1988 | Med Cutan Ibero Lat Am | pmid:3073279 |
| Sowden J et al. | Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid. | 1988 | Clin. Exp. Dermatol. | pmid:3256454 |
| Stamatiadis D et al. | Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. | 1988 | Br. J. Dermatol. | pmid:3207614 |
| Mayer-da Silva A et al. | Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. | 1987 | Acta Derm. Venereol. | pmid:2438874 |
| Nazzaro-Porro M | Azelaic acid. | 1987 | J. Am. Acad. Dermatol. | pmid:2963038 |
| Azelaic acid in lentigo maligna. | 1987 | Br. J. Dermatol. | pmid:3580294 | |
| Grosshans E and Chartier C | [Therapeutic depigmentation agents]. | 1987 | Schweiz. Rundsch. Med. Prax. | pmid:3671942 |
| Schallreuter KU and Wood JM | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. | 1987 | Cancer Lett. | pmid:3652030 |
| Hu F et al. | Effects of dicarboxylic acids on normal and malignant melanocytes in culture. | 1986 | Br. J. Dermatol. | pmid:3942687 |
| Leeming JP et al. | The in vitro antimicrobial effect of azelaic acid. | 1986 | Br. J. Dermatol. | pmid:2947607 |
| Rocchiccioli F et al. | Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. | 1986 | Pediatr. Res. | pmid:3945517 |
| Auld J | Topical therapy of acne. | 1986 | Australas. J. Dermatol. | pmid:2957990 |
| Bladon PT et al. | Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. | 1986 | Br. J. Dermatol. | pmid:2938615 |
| Geier G et al. | [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. | 1986 | Hautarzt | pmid:3700102 |
| Robins EJ et al. | Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1986 | J. Invest. Dermatol. | pmid:3734479 |
| Ortonne JP | [Depigmenting chemical agents]. | 1986 | Ann Dermatol Venereol | pmid:3800227 |
| Ward BJ et al. | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. | 1986 | J. Invest. Dermatol. | pmid:3745962 |
| McLean DI and Peter KK | Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. | 1986 | Br. J. Dermatol. | pmid:3718862 |
| Robins EJ et al. | Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. | 1985 | J. Invest. Dermatol. | pmid:4031537 |
| Gassmueller H et al. | Azelaic acid and sebum excretion rate. | 1985 | Br. J. Dermatol. | pmid:2937439 |
| Picardo M et al. | Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts. | 1985 | Biochem. Pharmacol. | pmid:4004885 |
| Pathak MA et al. | An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1985 | J. Invest. Dermatol. | pmid:4031538 |
| Leibl H et al. | Inhibition of DNA synthesis of melanoma cells by azelaic acid. | 1985 | J. Invest. Dermatol. | pmid:4056455 |
| Robins EJ et al. | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. | 1985 | Br. J. Dermatol. | pmid:4096883 |
| Breathnach AS et al. | Azelaic acid. | 1984 | Br. J. Dermatol. | pmid:6234914 |
| Mingrone G et al. | Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. | 1984 | Exp Pathol | pmid:6539234 |
| Passi S et al. | Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631243 |
| Nazzaro-Porro M et al. | Beneficial effect of 15% azelaic acid cream on acne vulgaris. | 1983 | Br. J. Dermatol. | pmid:6222755 |
| Marsden JR and Shuster S | The effect of azelaic acid on acne. | 1983 | Br. J. Dermatol. | pmid:6228247 |
| Willshaw HE and Rubinstein K | Azelaic acid in the treatment of ocular and adnexal malignant melanoma. | 1983 | Br J Ophthalmol | pmid:6848136 |
| [Advances in pigment studies]. | 1983 | Hautarzt | pmid:6678891 | |
| Maru U et al. | [In vitro diffusion and skin penetration of azelaic preparations: study of correlations]. | 1982 May-Jun | J Pharm Belg | pmid:7131228 |