Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Clark AA et al. | Odorants specifically modulate chemotaxis and tissue retention of CD4+ T cells via cyclic adenosine monophosphate induction. | 2016 | J. Leukoc. Biol. | pmid:27154353 |
Samycia M and Lam JM | Infantile acne. | 2016 | CMAJ | pmid:27873756 |
Lim GH et al. | Role of plasmodesmata and plasmodesmata localizing proteins in systemic immunity. | 2016 | Plant Signal Behav | pmid:27645210 |
Lim GH et al. | Plasmodesmata Localizing Proteins Regulate Transport and Signaling during Systemic Acquired Immunity in Plants. | 2016 | Cell Host Microbe | pmid:27078071 |
Helfrich YR and Maier LM | Topical and oral therapeutic approach to rosacea. | 2016 | Semin Cutan Med Surg | pmid:27416312 |
Asai Y et al. | Canadian Clinical Practice Guidelines for Rosacea. | 2016 | J Cutan Med Surg | pmid:27207355 |
Le Lay C et al. | Identification and quantification of antifungal compounds produced by lactic acid bacteria and propionibacteria. | 2016 | Int. J. Food Microbiol. | pmid:27350657 |
Gupta G et al. | Ivermectin 1% cream for rosacea. | 2015 Jul-Aug | Skin Therapy Lett. | pmid:26382711 |
Gordy JW et al. | Comparative Effectiveness of Potential Elicitors of Plant Resistance against Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) in Four Crop Plants. | 2015 | PLoS ONE | pmid:26332833 |
Karimi AA et al. | Improvement of tissue survival of skin flaps by 5α-reductase inhibitors: possible involvement of nitric oxide and inducible nitric oxide synthase. | 2015 | Iran. Biomed. J. | pmid:25864816 |
van Zuuren EJ et al. | Interventions for rosacea. | 2015 | Cochrane Database Syst Rev | pmid:25919144 |
Ganzetti G et al. | Rosacea: could topical azelaic acid and oral tetracyclines modify videocapillaroscopic pattern? | 2014 Mar-Apr | Skinmed | pmid:24933858 |
Gołębiowski M et al. | Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. | 2014 | J. Appl. Microbiol. | pmid:24238211 |
Wittek F et al. | Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. | 2014 | J. Exp. Bot. | pmid:25114016 |
Wang C et al. | Free radicals mediate systemic acquired resistance. | 2014 | Cell Rep | pmid:24726369 |
Shariff A et al. | Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. | 2014 | Dermatol. Online J. | pmid:24656277 |
Del Rosso JQ and Kircik LH | Update on the management of rosacea: a status report on the current role and new horizons with topical azelaic acid. | 2014 | J Drugs Dermatol | pmid:25607798 |
Del Rosso JQ et al. | Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 5: a guide on the management of rosacea. | 2014 | Cutis | pmid:24738094 |
Reis CP et al. | Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. | 2014 | Drug Dev Ind Pharm | pmid:23480566 |
Han S et al. | Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS. | 2014 | AAPS PharmSciTech | pmid:24166667 |
Sieber MA and Hegel JK | Azelaic acid: Properties and mode of action. | 2014 | Skin Pharmacol Physiol | pmid:24280644 |
Vargas-Diez E et al. | Azelaic acid in the treatment of acne in adult females: case reports. | 2014 | Skin Pharmacol Physiol | pmid:24280645 |
Aytekin M et al. | Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery. | 2013 | Drug Dev Ind Pharm | pmid:22480294 |
Maes M et al. | Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression. | 2013 | J Affect Disord | pmid:22898471 |
Bayerl C | [Acne therapy in pregnancy]. | 2013 | Hautarzt | pmid:23430167 |
Muthulakshmi S and Saravanan R | Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice. | 2013 | Biochimie | pmid:23402910 |
Quigley EA and Halpern AC | Microinvasive melanoma: cutaneous pharmacotherapeutic approaches. | 2013 | Am J Clin Dermatol | pmid:23479385 |
Melnik BC and Schmitz G | Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? | 2013 | Exp. Dermatol. | pmid:23800068 |
Yu K et al. | A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity. | 2013 | Cell Rep | pmid:23602565 |
Woolery-Lloyd HC et al. | Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. | 2013 | J Drugs Dermatol | pmid:23652891 |
Reis CP et al. | Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles. | 2013 | Microsc. Microanal. | pmid:23673203 |
Briganti S et al. | Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. | 2013 | Exp. Dermatol. | pmid:23278893 |
Muthulakshmi S and Saravanan R | Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice. | 2013 | Mol. Cell. Biochem. | pmid:23361364 |
Chauhan N and Ellis DA | Rosacea: pathophysiology and management principles. | 2013 | Facial Plast Surg Clin North Am | pmid:23369595 |
Jackson JM et al. | Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea. | 2013 | J Drugs Dermatol | pmid:23545911 |
Schöfer H | [Topical therapy of rosacea]. | 2013 | Hautarzt | pmid:23780475 |
Alzweiri M et al. | Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker. | 2013 | J Sep Sci | pmid:23893928 |
Han S et al. | Application of HPLC with ELSD detection for the assessment of azelaic acid impurities in liposomal formulation. | 2013 | ScientificWorldJournal | pmid:24228008 |
von Schönfels W et al. | Metabolic signature of electrosurgical liver dissection. | 2013 | PLoS ONE | pmid:24058442 |
Coda AB et al. | Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. | 2013 | J. Am. Acad. Dermatol. | pmid:23871720 |
Draelos ZD et al. | Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study. | 2013 | Cutis | pmid:24416747 |
Zheng P et al. | A novel urinary metabolite signature for diagnosing major depressive disorder. | 2013 | J. Proteome Res. | pmid:24224655 |
Pazoki-Toroudi H et al. | Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia. | 2012 Sep-Oct | Skinmed | pmid:23163069 |
Sarkar R et al. | Newer and upcoming therapies for melasma. | 2012 Jul-Aug | Indian J Dermatol Venereol Leprol | pmid:22772611 |
Rozema E et al. | Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22675394 |
Zhao H et al. | Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome. | 2012 | Evid Based Complement Alternat Med | pmid:22675387 |
Simonart T | Newer approaches to the treatment of acne vulgaris. | 2012 | Am J Clin Dermatol | pmid:22920095 |
Lorenc-Kukula K et al. | Biochemical and Molecular-Genetic Characterization of SFD1's Involvement in Lipid Metabolism and Defense Signaling. | 2012 | Front Plant Sci | pmid:22645576 |
Reinholz M et al. | Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. | 2012 | Ann Dermatol | pmid:22577261 |
Estronca LM et al. | Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model. | 2012 | PLoS ONE | pmid:22514671 |
Wang HW et al. | Insight into the molecular evolution of non-specific lipid transfer proteins via comparative analysis between rice and sorghum. | 2012 | DNA Res. | pmid:22368182 |
Park SY et al. | The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus. | 2012 | Ann Dermatol | pmid:22363153 |
Li N et al. | Effect of ionization and vehicle on skin absorption and penetration of azelaic acid. | 2012 | Drug Dev Ind Pharm | pmid:22111946 |
Zoeller M et al. | Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid. | 2012 | Plant Physiol. | pmid:22822212 |
Chaturvedi R et al. | An abietane diterpenoid is a potent activator of systemic acquired resistance. | 2012 | Plant J. | pmid:22385469 |
Bhatia ND and Del Rosso JQ | Optimal management of papulopustular rosacea: rationale for combination therapy. | 2012 | J Drugs Dermatol | pmid:22777226 |
Hsieh PW et al. | The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin. | 2012 | Eur J Pharm Biopharm | pmid:22469554 |
Fallen RS and Gooderham M | Rosacea: update on management and emerging therapies. | 2012 | Skin Therapy Lett. | pmid:23223767 |
Shalita AR et al. | Inflammatory acne management with a novel prescription dietary supplement. | 2012 | J Drugs Dermatol | pmid:23377512 |
Matsubara T et al. | Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. | 2012 | Cell Metab. | pmid:23140643 |
Khanna N and Rasool S | Facial melanoses: Indian perspective. | 2011 Sep-Oct | Indian J Dermatol Venereol Leprol | pmid:21860153 |
Manzano E et al. | Study of the GC-MS determination of the palmitic-stearic acid ratio for the characterisation of drying oil in painting: La Encarnación by Alonso Cano as a case study. | 2011 | Talanta | pmid:21530791 |
Parodi A et al. | Treatment of rosacea. | 2011 | Ann Dermatol Venereol | pmid:22183101 |
Kircik LH | Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study. | 2011 | J Drugs Dermatol | pmid:21637899 |
Wheeland RG and Dhawan S | Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system. | 2011 | J Drugs Dermatol | pmid:21637900 |
van Zuuren EJ et al. | Interventions for rosacea. | 2011 | Cochrane Database Syst Rev | pmid:21412882 |
Sato C et al. | Cellulase applied to the leaves of sweet pepper (Capsicum annuum L. var. grossum) upregulates the production of salicylic and azelaic acids. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21512237 |
Castellucci N et al. | Formation of gels in the presence of metal ions. | 2011 | Amino Acids | pmid:21487726 |
May D et al. | Clinical inquiries. What is the most effective treatment for acne rosacea? | 2011 | J Fam Pract | pmid:21301648 |
Pazoki-Toroudi H et al. | Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. | 2011 | Cutan Ocul Toxicol | pmid:21612319 |
Karavelidis V et al. | Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior. | 2011 | Int J Nanomedicine | pmid:22162659 |
Elewski BE et al. | Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. | 2011 | J Eur Acad Dermatol Venereol | pmid:20586834 |
Staroverov SA et al. | Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma. | 2011 | J. Vet. Sci. | pmid:22122895 |
Champigny MJ et al. | Localization of DIR1 at the tissue, cellular and subcellular levels during Systemic Acquired Resistance in Arabidopsis using DIR1:GUS and DIR1:EGFP reporters. | 2011 | BMC Plant Biol. | pmid:21896186 |
Song F et al. | Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study. | 2011 | BMJ | pmid:21846695 |
Abaffy T and Defazio AR | The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility. | 2011 | BMC Res Notes | pmid:21548958 |
Purdy S and de Berker D | Acne vulgaris. | 2011 | BMJ Clin Evid | pmid:21477388 |
McFalda WL and Roebuck HL | Rational management of papulopustular rosacea with concomitant facial seborrheic dermatitis: a case report. | 2011 | J Clin Aesthet Dermatol | pmid:21278898 |
Liu C et al. | Heterogeneous reaction of suspended phosmet particles with NO3 radicals. | 2011 | J Phys Chem A | pmid:21870875 |
Cuevas P et al. | Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea. | 2011 | BMJ Case Rep | pmid:22675033 |
Fabbrocini G et al. | Skin needling to enhance depigmenting serum penetration in the treatment of melasma. | 2011 | Plast Surg Int | pmid:22567235 |
Parodi A et al. | [Treatment of rosacea]. | 2011 | Ann Dermatol Venereol | pmid:21907876 |
Schnopp C and Mempel M | Acne vulgaris in children and adolescents. | 2011 | Minerva Pediatr. | pmid:21909065 |
Del Rosso JQ and Bhatia N | Azelaic acid gel 15% in the management of papulopustular rosacea: a status report on available efficacy data and clinical application. | 2011 | Cutis | pmid:21916272 |
Sheth VM and Pandya AG | Melasma: a comprehensive update: part II. | 2011 | J. Am. Acad. Dermatol. | pmid:21920242 |
Yu L et al. | Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry. | 2011 | J. Gastroenterol. Hepatol. | pmid:21443661 |
Alsantali A | Alopecia areata: a new treatment plan. | 2011 | Clin Cosmet Investig Dermatol | pmid:21833161 |
Farshi S | Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma. | 2011 | J Cosmet Dermatol | pmid:22151936 |
Wang H et al. | [Chemical constituents of Halenia elliptica]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22779176 |
Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
Whitney KM and Ditre CM | Management strategies for acne vulgaris. | 2011 | Clin Cosmet Investig Dermatol | pmid:21691566 |
Rathi SK | Acne vulgaris treatment : the current scenario. | 2011 | Indian J Dermatol | pmid:21572783 |
Chudasama A et al. | Investigation of microemulsion system for transdermal delivery of itraconazole. | 2011 | J Adv Pharm Technol Res | pmid:22171289 |
Schauber J | [Antimicrobial peptides, Vitamin D₃ and more. How rosacea may develop]. | 2011 | Hautarzt | pmid:22002717 |
Salimon J et al. | Synthesis and physical properties of estolide ester using saturated Fatty Acid and ricinoleic Acid. | 2011 | J Autom Methods Manag Chem | pmid:22007150 |
Jansen T et al. | Steroid-induced periorificial dermatitis in children--clinical features and response to azelaic acid. | 2010 Mar-Apr | Pediatr Dermatol | pmid:19804495 |
Ghosh S | Chemical leukoderma: what's new on etiopathological and clinical aspects? | 2010 Jul-Sep | Indian J Dermatol | pmid:21063518 |
Barabash R et al. | [Nelson syndrome: a rare cause of generalized hyperpigmentation of the skin]. | 2010 Jan-Feb | Actas Dermosifiliogr | pmid:20109395 |
Hoye TR et al. | Total synthesis of peloruside A through kinetic lactonization and relay ring-closing metathesis cyclization reactions. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20645374 |
Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |