Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sand M et al. | Cutaneous lesions of the nose. | 2010 | Head Face Med | pmid:20525327 |
Yu JS and Kim AK | Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells. | 2010 | J. Biomed. Sci. | pmid:20804622 |
Iraji F et al. | Efficacy of 15% azelaic acid in psoriasis vulgaris: a randomized, controlled clinical trial. | 2010 | J Drugs Dermatol | pmid:20684146 |
Merkviladze N et al. | The efficacy of topical drugs in treatment of noninflammatory acne vulgaris. | 2010 | Georgian Med News | pmid:20972276 |
Del Rosso JQ | Effectiveness and safety of doxycycline 40 mg (30-mg immediate-release and 10-mg delayed-release beads) once daily as add-on therapy to existing topical regimens for the treatment of papulopustular rosacea: results from a community-based trial. | 2010 | Cutis | pmid:21229827 |
Choi YS et al. | A study of the efficacy of cleansers for acne vulgaris. | 2010 | J Dermatolog Treat | pmid:20394494 |
Del Rosso JQ et al. | Efficacy of topical azelaic acid (AzA) gel 15% plus oral doxycycline 40 mg versus metronidazole gel 1% plus oral doxycycline 40 mg in mild-to-moderate papulopustular rosacea. | 2010 | J Drugs Dermatol | pmid:20645521 |
Preisz K and Kárpáti S | [Rosacea: pathogenesis, clinical forms and therapy]. | 2010 | Orv Hetil | pmid:20650811 |
Mastrofrancesco A et al. | Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. | 2010 | Exp. Dermatol. | pmid:20545756 |
Scheinfeld N and Berk T | A review of the diagnosis and treatment of rosacea. | 2010 | Postgrad Med | pmid:20107297 |
Truman WM et al. | Arabidopsis auxin mutants are compromised in systemic acquired resistance and exhibit aberrant accumulation of various indolic compounds. | 2010 | Plant Physiol. | pmid:20081042 |
Li N et al. | Effect of 1,4-cyclohexanediol on percutaneous absorption and penetration of azelaic acid. | 2010 | Int J Pharm | pmid:20025951 |
Garelnabi M et al. | Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples. | 2010 | N Am J Med Sci | pmid:22558586 |
Davis EC and Callender VD | Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. | 2010 | J Clin Aesthet Dermatol | pmid:20725554 |
Chae K et al. | A multifaceted study of stigma/style cysteine-rich adhesin (SCA)-like Arabidopsis lipid transfer proteins (LTPs) suggests diversified roles for these LTPs in plant growth and reproduction. | 2010 | J. Exp. Bot. | pmid:20667964 |
Verma P and Pathak K | Therapeutic and cosmeceutical potential of ethosomes: An overview. | 2010 | J Adv Pharm Technol Res | pmid:22247858 |
Chaouch S et al. | Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner. | 2010 | Plant Physiol. | pmid:20543092 |
Hoye TR et al. | Total synthesis of peloruside A through kinetic lactonization and relay ring-closing metathesis cyclization reactions. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20645374 |
Sun H et al. | Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). | 2010 | Stand Genomic Sci | pmid:21304737 |
Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |
Xia Y et al. | The glabra1 mutation affects cuticle formation and plant responses to microbes. | 2010 | Plant Physiol. | pmid:20699396 |
Jones DA | Rosacea, reactive oxygen species, and azelaic Acid. | 2009 | J Clin Aesthet Dermatol | pmid:20967185 |
Melnik BC et al. | Anti-acne agents attenuate FGFR2 signal transduction in acne. | 2009 | J. Invest. Dermatol. | pmid:19225542 |
Rup S et al. | The ultrasound-assisted oxidative scission of monoenic fatty acids by ruthenium tetroxide catalysis: influence of the mixture of solvents. | 2009 | Ultrason Sonochem | pmid:18799341 |
Del Rosso JQ et al. | Impact of order of application of moisturizers on percutaneous absorption kinetics: evaluation of sequential application of moisturizer lotions and azelaic acid gel 15% using a human skin model. | 2009 | Cutis | pmid:19363903 |
Jung HW et al. | Priming in systemic plant immunity. | 2009 | Science | pmid:19342588 |
Panyosak A et al. | Safety assessment of azelaic acid and its derivatives entrapped in nanovesicles. | 2009 | Hum Exp Toxicol | pmid:19755450 |
Que SK and Bergstrom KG | Hyperpigmentation: old problem, new therapies. | 2009 | J Drugs Dermatol | pmid:19746682 |
Del Rosso JQ | The use of moisturizers as an integral component of topical therapy for rosacea: clinical results based on the Assessment of Skin Characteristics Study. | 2009 | Cutis | pmid:19746764 |
Korting HC and Schöllmann C | Current topical and systemic approaches to treatment of rosacea. | 2009 | J Eur Acad Dermatol Venereol | pmid:19508315 |
Thiboutot DM et al. | A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy. | 2009 | J Drugs Dermatol | pmid:19588640 |
Shah J | Plants under attack: systemic signals in defence. | 2009 | Curr. Opin. Plant Biol. | pmid:19608451 |
Parker JE | The quest for long-distance signals in plant systemic immunity. | 2009 | Sci Signal | pmid:19436056 |
Gooderham M | Rosacea and its topical management. | 2009 | Skin Therapy Lett. | pmid:19330270 |
Elsaie ML and Choudhary S | Updates on the pathophysiology and management of acne rosacea. | 2009 | Postgrad Med | pmid:19820288 |
Del Rosso JQ | The use of sodium sulfacetamide 10%-sulfur 5% emollient foam in the treatment of acne vulgaris. | 2009 | J Clin Aesthet Dermatol | pmid:20729951 |
Mostafa FF et al. | Comparative study of some treatment modalities of rosacea. | 2009 | J Eur Acad Dermatol Venereol | pmid:18705632 |
Smit N et al. | The hunt for natural skin whitening agents. | 2009 | Int J Mol Sci | pmid:20054473 |
Safoury OS et al. | A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma. | 2009 | Indian J Dermatol | pmid:20049268 |
Fujitani K et al. | Preparation of polycarboxylic acids by oxidative cleavage with oxygen / Co-Mn-Br system. | 2009 | J Oleo Sci | pmid:19915320 |
Wu YH et al. | Effects of Chinese herbal medicine combined with He-Ne laser on lipoperoxide and superoxide dismutase in chloasma patients. | 2009 | J Tradit Chin Med | pmid:19894376 |
Ebanks JP et al. | Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. | 2009 | Int J Mol Sci | pmid:19865532 |
Goldgar C et al. | Treatment options for acne rosacea. | 2009 | Am Fam Physician | pmid:19725487 |
Culp B and Scheinfeld N | Rosacea: a review. | 2009 | P T | pmid:19562004 |
Zeng JP et al. | 2,2'-(Heptane-1,7-di-yl)dibenz-imidazo-lium chloride nitrate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21582272 |
Niimura Y | On the origin and evolution of vertebrate olfactory receptor genes: comparative genome analysis among 23 chordate species. | 2009 | Genome Biol Evol | pmid:20333175 |
Patwardhan N | Conference Report: ACSICON 2008. | 2009 | J Cutan Aesthet Surg | pmid:20300376 |
Bowler PJ | Impact on facial rejuvenation with dermatological preparations. | 2009 | Clin Interv Aging | pmid:19503770 |
Sobottka A and Lehmann P | [Rosacea 2009 : new advances in pathophysiology, clinical staging and therapeutic strategies]. | 2009 | Hautarzt | pmid:19957073 |
Keri J and Shiman M | An update on the management of acne vulgaris. | 2009 | Clin Cosmet Investig Dermatol | pmid:21436973 |
Lanz C et al. | Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. | 2009 | Radiat. Res. | pmid:19630524 |
De Filippis D et al. | Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. | 2009 | J. Cell. Mol. Med. | pmid:18429935 |
Bandyopadhyay D | Topical treatment of melasma. | 2009 | Indian J Dermatol | pmid:20101327 |
Crea F et al. | Sequestering ability of polycarboxylic ligands towards dioxouranium(VI). | 2008 | Talanta | pmid:18585146 |
Gollnick H and Layton A | Azelaic acid 15% gel in the treatment of rosacea. | 2008 | Expert Opin Pharmacother | pmid:18803456 |
Lee GS | Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: a short report. | 2008 | J Cosmet Laser Ther | pmid:18830869 |
Thiboutot D | Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris. | 2008 | J Drugs Dermatol | pmid:18246693 |
Stewart JJ | Application of the PM6 method to modeling the solid state. | 2008 | J Mol Model | pmid:18449579 |
Craythorne EE and Lawrence CM | Observational study of topical imiquimod immunotherapy in the treatment of difficult lentigo maligna. | 2008 | Clin Med Oncol | pmid:21892331 |
Kanitakis J | Linea fusca in a male adolescent successfully treated with azelaic acid. | 2008 | J Eur Acad Dermatol Venereol | pmid:18331308 |
Purdy S and Deberker D | Acne vulgaris. | 2008 | BMJ Clin Evid | pmid:19450306 |
Chen Z et al. | Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. | 2008 | J. Am. Chem. Soc. | pmid:18278910 |
Herkenne C et al. | In vivo methods for the assessment of topical drug bioavailability. | 2008 | Pharm. Res. | pmid:17985216 |
Arizaga GG et al. | Chemical modification of zinc hydroxide nitrate and Zn-Al-layered double hydroxide with dicarboxylic acids. | 2008 | J Colloid Interface Sci | pmid:18243238 |
Thiboutot DM et al. | Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea. | 2008 | J Drugs Dermatol | pmid:18561584 |
Iraji F et al. | Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. | 2007 Mar-Apr | Indian J Dermatol Venereol Leprol | pmid:17456913 |
Akman A et al. | Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. | 2007 | Arch. Dermatol. Res. | pmid:17710426 |
Elewski BE | Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. | 2007 | Cutis | pmid:17330623 |
Stinco G et al. | Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. | 2007 | J Eur Acad Dermatol Venereol | pmid:17309452 |
Nojima S et al. | Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus. | 2007 | J. Chem. Ecol. | pmid:17394050 |
Hinz DC | Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace. | 2007 | J Pharm Biomed Anal | pmid:17280812 |
Manosroi A et al. | Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines. | 2007 | J Drug Target | pmid:17541842 |
Satoh M et al. | Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. | 2007 | Circulation | pmid:17562954 |
Colón LE et al. | Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. | 2007 | Cutis | pmid:17500380 |
Gupta AK and Gover MD | Azelaic acid (15% gel) in the treatment of acne rosacea. | 2007 | Int. J. Dermatol. | pmid:17472690 |
Alevizos A et al. | Acne treatments: consider these options--and issues. | 2007 | J Fam Pract | pmid:17475157 |
Conde JF et al. | Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. | 2007 | J Drugs Dermatol | pmid:17679183 |
Prignano F et al. | Therapeutical approaches in melasma. | 2007 | Dermatol Clin | pmid:17662899 |
Maher HK | Rosacea. | 2007 | AAOHN J | pmid:18183803 |
Piskin S and Uzunali E | A review of the use of adapalene for the treatment of acne vulgaris. | 2007 | Ther Clin Risk Manag | pmid:18472984 |
Elewski BE et al. | In reference to the October 2004 comprehensive overview of rosacea therapy. | 2007 | J. Am. Acad. Dermatol. | pmid:17870440 |
van Zuuren EJ et al. | Systematic review of rosacea treatments. | 2007 | J. Am. Acad. Dermatol. | pmid:17190628 |
Erbil H et al. | Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. | 2007 | J. Dermatol. | pmid:17204097 |
Weschler CJ | Ozone's impact on public health: contributions from indoor exposures to ozone and products of ozone-initiated chemistry. | 2006 | Environ. Health Perspect. | pmid:17035131 |
Del Rosso JQ et al. | Azelaic acid gel 15%: clinical versatility in the treatment of rosacea. | 2006 | Cutis | pmid:17354468 |
Goodman G | Managing acne vulgaris effectively. | 2006 | Aust Fam Physician | pmid:16969442 |
Purdy S | Acne vulgaris. | 2006 | Clin Evid | pmid:16973084 |
Liu RH et al. | Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. | 2006 | Arch Dermatol | pmid:16924055 |
Fleischer AB | The evolution of azelaic acid. | 2006 | Cutis | pmid:16566281 |
Draelos ZD | The rationale for advancing the formulation of azelaic acid vehicles. | 2006 | Cutis | pmid:16566282 |
Elewski B and Thiboutot D | A clinical overview of azelaic acid. | 2006 | Cutis | pmid:16566283 |
Bikowski JB | Case studies. | 2006 | Cutis | pmid:16566284 |
Del Rosso JQ | The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. | 2006 | Cutis | pmid:16566285 |
Nally JB and Berson DS | Topical therapies for rosacea. | 2006 | J Drugs Dermatol | pmid:16468288 |
Zhang JF et al. | [Studies on chemical constituents in root tuber of Cynanchum auriculatum]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048663 |
Gupta AK et al. | The treatment of melasma: a review of clinical trials. | 2006 | J. Am. Acad. Dermatol. | pmid:17097400 |
Worret WI and Fluhr JW | [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. | 2006 | J Dtsch Dermatol Ges | pmid:16638058 |
Wolf JE et al. | Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. | 2006 | Cutis | pmid:16706244 |
Draelos ZD et al. | An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients. | 2006 | J Cosmet Dermatol | pmid:17173568 |
Devereux M et al. | Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 | Bioinorg Chem Appl | pmid:17497019 |