Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kanitakis J | Linea fusca in a male adolescent successfully treated with azelaic acid. | 2008 | J Eur Acad Dermatol Venereol | pmid:18331308 |
pmid:18280490 | ||||
Chen Z et al. | Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. | 2008 | J. Am. Chem. Soc. | pmid:18278910 |
Thiboutot D | Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris. | 2008 | J Drugs Dermatol | pmid:18246693 |
Arizaga GG et al. | Chemical modification of zinc hydroxide nitrate and Zn-Al-layered double hydroxide with dicarboxylic acids. | 2008 | J Colloid Interface Sci | pmid:18243238 |
Maher HK | Rosacea. | 2007 | AAOHN J | pmid:18183803 |
Baliña LM and Graupe K | The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. | 1991 | Int. J. Dermatol. | pmid:1816137 |
pmid:18045355 | ||||
Herkenne C et al. | In vivo methods for the assessment of topical drug bioavailability. | 2008 | Pharm. Res. | pmid:17985216 |
pmid:17931096 | ||||
pmid:17927163 | ||||
Elewski BE et al. | In reference to the October 2004 comprehensive overview of rosacea therapy. | 2007 | J. Am. Acad. Dermatol. | pmid:17870440 |
Akman A et al. | Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. | 2007 | Arch. Dermatol. Res. | pmid:17710426 |
Passi S et al. | The oxyradical-scavenging activity of azelaic acid in biological systems. | 1991 | Free Radic. Res. Commun. | pmid:1769610 |
Conde JF et al. | Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. | 2007 | J Drugs Dermatol | pmid:17679183 |
Prignano F et al. | Therapeutical approaches in melasma. | 2007 | Dermatol Clin | pmid:17662899 |
pmid:17622422 | ||||
pmid:17566774 | ||||
Satoh M et al. | Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. | 2007 | Circulation | pmid:17562954 |
Manosroi A et al. | Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines. | 2007 | J Drug Target | pmid:17541842 |
pmid:17508766 | ||||
Colón LE et al. | Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. | 2007 | Cutis | pmid:17500380 |
Devereux M et al. | Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 | Bioinorg Chem Appl | pmid:17497019 |
Alevizos A et al. | Acne treatments: consider these options--and issues. | 2007 | J Fam Pract | pmid:17475157 |
Gupta AK and Gover MD | Azelaic acid (15% gel) in the treatment of acne rosacea. | 2007 | Int. J. Dermatol. | pmid:17472690 |
Iraji F et al. | Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. | 2007 Mar-Apr | Indian J Dermatol Venereol Leprol | pmid:17456913 |
pmid:17394294 | ||||
Nojima S et al. | Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus. | 2007 | J. Chem. Ecol. | pmid:17394050 |
Del Rosso JQ et al. | Azelaic acid gel 15%: clinical versatility in the treatment of rosacea. | 2006 | Cutis | pmid:17354468 |
Elewski BE | Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. | 2007 | Cutis | pmid:17330623 |
Stinco G et al. | Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. | 2007 | J Eur Acad Dermatol Venereol | pmid:17309452 |
Hinz DC | Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace. | 2007 | J Pharm Biomed Anal | pmid:17280812 |
pmid:17268656 | ||||
Bojar RA et al. | The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. | 1991 | J. Antimicrob. Chemother. | pmid:1726169 |
pmid:17249752 | ||||
Erbil H et al. | Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. | 2007 | J. Dermatol. | pmid:17204097 |
van Zuuren EJ et al. | Systematic review of rosacea treatments. | 2007 | J. Am. Acad. Dermatol. | pmid:17190628 |
Draelos ZD et al. | An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients. | 2006 | J Cosmet Dermatol | pmid:17173568 |
pmid:17147560 | ||||
Fitton A and Goa KL | Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. | 1991 | Drugs | pmid:1712709 |
Gupta AK et al. | The treatment of melasma: a review of clinical trials. | 2006 | J. Am. Acad. Dermatol. | pmid:17097400 |
Zhang JF et al. | [Studies on chemical constituents in root tuber of Cynanchum auriculatum]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048663 |
Weschler CJ | Ozone's impact on public health: contributions from indoor exposures to ozone and products of ozone-initiated chemistry. | 2006 | Environ. Health Perspect. | pmid:17035131 |
pmid:17014483 | ||||
Purdy S | Acne vulgaris. | 2006 | Clin Evid | pmid:16973084 |
Goodman G | Managing acne vulgaris effectively. | 2006 | Aust Fam Physician | pmid:16969442 |
Liu RH et al. | Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. | 2006 | Arch Dermatol | pmid:16924055 |
Hung HM et al. | Products and mechanisms of the reaction of oleic acid with ozone and nitrate radical. | 2005 | J Phys Chem A | pmid:16833788 |
[Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991]. | 1991 | Hautarzt | pmid:1674505 | |
pmid:16737240 |