Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid:20176393 | ||||
pmid:28235481 | ||||
pmid:25575741 | ||||
pmid: | ||||
Maher HK | Rosacea. | 2007 | AAOHN J | pmid:18183803 |
Han S et al. | Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS. | 2014 | AAPS PharmSciTech | pmid:24166667 |
Zeng JP et al. | 2,2'-(Heptane-1,7-di-yl)dibenz-imidazo-lium chloride nitrate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21582272 |
Breathnach AS et al. | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2672685 |
Mayer-da-Silva A et al. | Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2475995 |
Töpert M et al. | Pharmacology and toxicology of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528255 |
Cunliffe WJ and Holland KT | Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528256 |
Katsambas A et al. | Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528257 |
Cavicchini S and Caputo R | Long-term treatment of acne with 20% azelaic acid cream. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528258 |
Hjorth N and Graupe K | Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528259 |
Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773613 | |
Nazzaro-Porro M et al. | Ten years' experience of treating lentigo maligna with topical azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773614 |
Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
Bjerke R et al. | Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea. | 1999 | Acta Derm. Venereol. | pmid:10598760 |
Mayer-da Silva A et al. | Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. | 1987 | Acta Derm. Venereol. | pmid:2438874 |
Barabash R et al. | [Nelson syndrome: a rare cause of generalized hyperpigmentation of the skin]. | 2010 Jan-Feb | Actas Dermosifiliogr | pmid:20109395 |
Lindow KB | Rosacea. An overview of diagnosis and management. | 2004 | Adv Nurse Pract | pmid:15615217 |
Russell JJ | Topical therapy for acne. | 2000 | Am Fam Physician | pmid:10670502 |
Goldgar C et al. | Treatment options for acne rosacea. | 2009 | Am Fam Physician | pmid:19725487 |
Feldman S et al. | Diagnosis and treatment of acne. | 2004 | Am Fam Physician | pmid:15152959 |
Mackrides PS and Shaughnessy AF | Azelaic acid therapy for acne. | 1996 | Am Fam Physician | pmid:8961845 |
Palassis J | The sampling and determination of azelaic acid in air. | 1978 | Am Ind Hyg Assoc J | pmid:727120 |
Simonart T | Newer approaches to the treatment of acne vulgaris. | 2012 | Am J Clin Dermatol | pmid:22920095 |
Sasmaz S and Arican O | Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. | 2005 | Am J Clin Dermatol | pmid:16343028 |
Frampton JE and Wagstaff AJ | Azelaic acid 15% gel: in the treatment of papulopustular rosacea. | 2004 | Am J Clin Dermatol | pmid:14979745 |
Bershad S | Azelaic acid: a viewpoint by Susan Bershad. | 2004 | Am J Clin Dermatol | pmid:14979746 |
Gupta AK | Azelaic acid : a viewpoint by Aditya K. Gupta. | 2004 | Am J Clin Dermatol | pmid:14979747 |
Marks R | Acne and its management beyond the age of 35 years. | 2004 | Am J Clin Dermatol | pmid:15663343 |
Rebora A | The management of rosacea. | 2002 | Am J Clin Dermatol | pmid:12180896 |
Quigley EA and Halpern AC | Microinvasive melanoma: cutaneous pharmacotherapeutic approaches. | 2013 | Am J Clin Dermatol | pmid:23479385 |
Pérez-Bernal A et al. | Management of facial hyperpigmentation. | 2000 Sep-Oct | Am J Clin Dermatol | pmid:11702317 |
Castellucci N et al. | Formation of gels in the presence of metal ions. | 2011 | Amino Acids | pmid:21487726 |
Hoye TR et al. | Total synthesis of peloruside A through kinetic lactonization and relay ring-closing metathesis cyclization reactions. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20645374 |
Reinholz M et al. | Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. | 2012 | Ann Dermatol | pmid:22577261 |
Park SY et al. | The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus. | 2012 | Ann Dermatol | pmid:22363153 |
Parodi A et al. | Treatment of rosacea. | 2011 | Ann Dermatol Venereol | pmid:22183101 |
Parodi A et al. | [Treatment of rosacea]. | 2011 | Ann Dermatol Venereol | pmid:21907876 |
Ortonne JP | [Depigmenting chemical agents]. | 1986 | Ann Dermatol Venereol | pmid:3800227 |
Januszewski AS et al. | Lipid-derived modifications of plasma proteins in experimental and human diabetes. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16037262 |
Zaffaroni N et al. | Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. | 1990 Nov-Dec | Anticancer Res. | pmid:2285231 |
Száraz I and Forsling W | Interaction between a capacitor electrolyte and gamma-aluminum oxide studied by Fourier transform infrared spectroscopy. | 2003 | Appl Spectrosc | pmid:14658693 |
Nazzaro-Porro M et al. | The depigmenting effect of azelaic acid. | 1990 | Arch Dermatol | pmid:2073286 |
Elewski BE et al. | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. | 2003 | Arch Dermatol | pmid:14623704 |
Wilkerson MG and Wilkin JK | Azelaic acid esters do not depigment pigmented guinea pig skin. | 1990 | Arch Dermatol | pmid:2301969 |
Grimes PE | Melasma. Etiologic and therapeutic considerations. | 1995 | Arch Dermatol | pmid:7492140 |