Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

Download all related citations
Per page 10 20 50 100 | Total 511
Authors Title Published Journal PubMed Link
Usatine RP et al. Acne vulgaris: a treatment update. 1998 Hosp Pract (1995) pmid:9484299
Jorand JP et al. The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. 1989 Horm. Metab. Res. pmid:2807145
New rosacea drug gets the red out. 2004 Health News pmid:15002371
Sand M et al. Cutaneous lesions of the nose. 2010 Head Face Med pmid:20525327
[Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991]. 1991 Hautarzt pmid:1674505
Sobottka A and Lehmann P [Rosacea 2009 : new advances in pathophysiology, clinical staging and therapeutic strategies]. 2009 Hautarzt pmid:19957073
Landthaler M et al. [Lentigo of the glans penis]. 1989 Hautarzt pmid:2732050
Bayerl C [Acne therapy in pregnancy]. 2013 Hautarzt pmid:23430167
Geier G et al. [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. 1986 Hautarzt pmid:3700102
Schöfer H [Topical therapy of rosacea]. 2013 Hautarzt pmid:23780475
Schauber J [Antimicrobial peptides, Vitamin D₃ and more. How rosacea may develop]. 2011 Hautarzt pmid:22002717
[Advances in pigment studies]. 1983 Hautarzt pmid:6678891
Merkviladze N et al. The efficacy of topical drugs in treatment of noninflammatory acne vulgaris. 2010 Georgian Med News pmid:20972276
Niimura Y On the origin and evolution of vertebrate olfactory receptor genes: comparative genome analysis among 23 chordate species. 2009 Genome Biol Evol pmid:20333175
Angius AG et al. [Evaluation of the anti-comedo effect of azelaic acid using the technique of horny layer biopsy and scanning electron microscopy]. 1990 G Ital Dermatol Venereol pmid:2149715
Zina G [Azelaic acid: an innovation in the treatment of acne. Introduction and history]. 1989 G Ital Dermatol Venereol pmid:2534549
Passi S et al. [Mechanism of azelaic acid action in acne]. 1989 G Ital Dermatol Venereol pmid:2534550
Cavicchini S and Caputo R [National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. 1989 G Ital Dermatol Venereol pmid:2534551
Giannotti B [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. 1989 G Ital Dermatol Venereol pmid:2534552
Colonna SM [Validity of azelaic acid in the therapy of acne. Long-term clinical results]. 1989 G Ital Dermatol Venereol pmid:2534553
Troccoli T et al. [Topical therapeutic action of azelaic acid in polymorphous acne]. 1989 G Ital Dermatol Venereol pmid:2534554
Nazzaro-Porro M et al. [Azelaic acid in the treatment of acne]. 1989 G Ital Dermatol Venereol pmid:2530163
Rigoni C et al. [Use of a cream based on 20% azelaic acid in the treatment of melasma]. 1989 Jan-Feb G Ital Dermatol Venereol pmid:2767714
Lorenc-Kukula K et al. Biochemical and Molecular-Genetic Characterization of SFD1's Involvement in Lipid Metabolism and Defense Signaling. 2012 Front Plant Sci pmid:22645576
Passi S et al. The oxyradical-scavenging activity of azelaic acid in biological systems. 1991 Free Radic. Res. Commun. pmid:1769610
Ruan H et al. Structure of a novel diterpenoid ester, fritillahupehin from bulbs of Fritillaria hupehensis Hsiao and K.C. Hsia. 2002 Fitoterapia pmid:12234570
Ferioli V et al. Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization. 1994 Farmaco pmid:8074784
Chauhan N and Ellis DA Rosacea: pathophysiology and management principles. 2013 Facial Plast Surg Clin North Am pmid:23369595
Del Rosso JQ Medical treatment of rosacea with emphasis on topical therapies. 2004 Expert Opin Pharmacother pmid:14680431
Gollnick H and Layton A Azelaic acid 15% gel in the treatment of rosacea. 2008 Expert Opin Pharmacother pmid:18803456
Mastrofrancesco A et al. Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. 2010 Exp. Dermatol. pmid:20545756
Melnik BC and Schmitz G Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? 2013 Exp. Dermatol. pmid:23800068
Briganti S et al. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. 2013 Exp. Dermatol. pmid:23278893
Täuber U et al. Percutaneous absorption of azelaic acid in humans. 1992 Exp. Dermatol. pmid:1365318
Lemic-Stojcevic L et al. Effect of azelaic acid on melanoma cells in culture. 1995 Exp. Dermatol. pmid:7640879
Mingrone G et al. Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. 1984 Exp Pathol pmid:6539234
Rozema E et al. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. 2012 Evid Based Complement Alternat Med pmid:22675394
Zhao H et al. Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome. 2012 Evid Based Complement Alternat Med pmid:22675387
Jansen T and Plewig G Advances and perspectives in acne therapy. 1997 Eur. J. Med. Res. pmid:9262484
Charnock C et al. Evaluation of the antibacterial efficacy of diesters of azelaic acid. 2004 Eur J Pharm Sci pmid:15066659
Hsieh PW et al. The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin. 2012 Eur J Pharm Biopharm pmid:22469554
Cetiner S et al. Phototoxic effects of topical azelaic acid, benzoyl peroxide and adapalene were not detected when applied immediately before UVB to normal skin. 2004 Jul-Aug Eur J Dermatol pmid:15319156
Gollnick HP et al. Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. 2001 Nov-Dec Eur J Dermatol pmid:11701404
Dong R and Yu LE Investigation of surface changes of nanoparticles using TM-AFM phase imaging. 2003 Environ. Sci. Technol. pmid:12854724
Weschler CJ Ozone's impact on public health: contributions from indoor exposures to ozone and products of ozone-initiated chemistry. 2006 Environ. Health Perspect. pmid:17035131
Herrero-Martínez JM et al. Separation of homologues and isomers of linear alkylbenzenesulfonates by capillary electrophoresis with sodium dodecyl sulfate, carboxylic acids and bile salts. 2003 Electrophoresis pmid:12601738
Fitton A and Goa KL Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. 1991 Drugs pmid:1712709
Azelaic acid--a new topical treatment for acne. 1993 Drug Ther Bull pmid:8344141
Li N et al. Effect of ionization and vehicle on skin absorption and penetration of azelaic acid. 2012 Drug Dev Ind Pharm pmid:22111946
Aytekin M et al. Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery. 2013 Drug Dev Ind Pharm pmid:22480294
Reis CP et al. Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. 2014 Drug Dev Ind Pharm pmid:23480566
Wang HW et al. Insight into the molecular evolution of non-specific lipid transfer proteins via comparative analysis between rice and sorghum. 2012 DNA Res. pmid:22368182
Sarkar R et al. A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients. 2002 Dermatology (Basel) pmid:12399672
Hermanns JF et al. Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents. 2000 Dermatology (Basel) pmid:11053913
Gollnick HP and Krautheim A Topical treatment in acne: current status and future aspects. 2003 Dermatology (Basel) pmid:12566803
Brasch J and Christophers E Azelaic acid has antimycotic properties in vitro. 1993 Dermatology (Basel) pmid:8435518
Gollnick H and Schramm M Topical drug treatment in acne. 1998 Dermatology (Basel) pmid:9557245
Hermanns JF et al. Assessment of topical hypopigmenting agents on solar lentigines of Asian women. 2002 Dermatology (Basel) pmid:12077522
Shariff A et al. Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. 2014 Dermatol. Online J. pmid:24656277
Halder RM and Richards GM Management of dyschromias in ethnic skin. 2004 Dermatol Ther pmid:15113282
Cayce KA et al. Hyperpigmentation: an overview of the common afflictions. 2004 Dermatol Nurs pmid:15624705
Gibson JR Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. 1997 Dermatol Nurs pmid:9392765
Prignano F et al. Therapeutical approaches in melasma. 2007 Dermatol Clin pmid:17662899
Ely H Dermatologic therapies you've probably never heard of. 1989 Dermatol Clin pmid:2646047
Del Rosso JQ A status report on the medical management of rosacea: focus on topical therapies. 2002 Cutis pmid:12469780
Wolf JE The role of topical metronidazole in the treatment of rosacea. 2004 Cutis pmid:14959942
Del Rosso JQ Effectiveness and safety of doxycycline 40 mg (30-mg immediate-release and 10-mg delayed-release beads) once daily as add-on therapy to existing topical regimens for the treatment of papulopustular rosacea: results from a community-based trial. 2010 Cutis pmid:21229827
Del Rosso JQ et al. Impact of order of application of moisturizers on percutaneous absorption kinetics: evaluation of sequential application of moisturizer lotions and azelaic acid gel 15% using a human skin model. 2009 Cutis pmid:19363903
Del Rosso JQ The use of moisturizers as an integral component of topical therapy for rosacea: clinical results based on the Assessment of Skin Characteristics Study. 2009 Cutis pmid:19746764
Elewski BE Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. 2007 Cutis pmid:17330623
Del Rosso JQ and Bhatia N Azelaic acid gel 15% in the management of papulopustular rosacea: a status report on available efficacy data and clinical application. 2011 Cutis pmid:21916272
Del Rosso JQ et al. Azelaic acid gel 15%: clinical versatility in the treatment of rosacea. 2006 Cutis pmid:17354468
Colón LE et al. Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. 2007 Cutis pmid:17500380
Wolf JE Present and future rosacea therapy. 2005 Cutis pmid:15810803
van Zuuren EJ and Graber MA The rigor of trials evaluating Rosacea treatments. 2005 Cutis pmid:15810805
Draelos ZD Noxious sensory perceptions in patients with mild to moderate rosacea treated with azelaic acid 15% gel. 2004 Cutis pmid:15551720
Fleischer AB The evolution of azelaic acid. 2006 Cutis pmid:16566281
Draelos ZD The rationale for advancing the formulation of azelaic acid vehicles. 2006 Cutis pmid:16566282
Elewski B and Thiboutot D A clinical overview of azelaic acid. 2006 Cutis pmid:16566283
Bikowski JB Case studies. 2006 Cutis pmid:16566284
Del Rosso JQ The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. 2006 Cutis pmid:16566285
Wolf JE et al. Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. 2006 Cutis pmid:16706244
Callender VD Considerations for treating acne in ethnic skin. 2005 Cutis pmid:16164153
Del Rosso JQ et al. Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 5: a guide on the management of rosacea. 2014 Cutis pmid:24738094
Draelos ZD et al. Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study. 2013 Cutis pmid:24416747
Gibson JR Rationale for the development of new topical treatments for acne vulgaris. 1996 Cutis pmid:8654127
Graupe K et al. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. 1996 Cutis pmid:8654128
Breathnach AS Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. 1996 Cutis pmid:8654129
Lowe NJ New approaches in dermatology: a clinical profile of azelaic acid. 1996 Cutis pmid:8654130
Rocamora V et al. Amelanotic lentigo maligna melanoma: report of a case and review of the literature. 1999 Cutis pmid:10431675
Pazoki-Toroudi H et al. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. 2011 Cutan Ocul Toxicol pmid:21612319
Shah J Plants under attack: systemic signals in defence. 2009 Curr. Opin. Plant Biol. pmid:19608451
van Zuuren EJ et al. Interventions for rosacea. 2011 Cochrane Database Syst Rev pmid:21412882
van Zuuren EJ et al. Interventions for rosacea. 2015 Cochrane Database Syst Rev pmid:25919144
Samycia M and Lam JM Infantile acne. 2016 CMAJ pmid:27873756
Sowden J et al. Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid. 1988 Clin. Exp. Dermatol. pmid:3256454
Nazzaro-Porro M et al. A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. 1996 Clin. Exp. Dermatol. pmid:8959915
Breathnach AC et al. Azelaic acid therapy in disorders of pigmentation. 1989 Apr-Jun Clin. Dermatol. pmid:2667735
Capristo E et al. A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples. 1999 Clin. Chim. Acta pmid:10556649
Spellman MC and Pincus SH Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. 1998 Jul-Aug Clin Ther pmid:9737831