| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Keratosis | D007642 | 9 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Melanosis | D008548 | 4 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pituitary Apoplexy | D010899 | 1 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Rhinophyma | D012224 | 1 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| RodrÃguez Prieto MA et al. | Treatment of lentigo maligna with azelaic acid. | 1993 | Int. J. Dermatol. | pmid:8505164 |
| Banerjee S et al. | 2'-(3 alpha-Benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'- dihydrooxazoline-N-oxyl as a potential spin probe for model membranes. | 1994 | Steroids | pmid:7940616 |
| Pattarino F et al. | Topical delivery systems for azelaic acid: effect of the suspended drug in microemulsion. | 1994 | Pharmazie | pmid:8140138 |
| Ferioli V et al. | Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization. | 1994 | Farmaco | pmid:8074784 |
| Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
| Nguyen QH and Bui TP | Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. | 1995 | Int. J. Dermatol. | pmid:7737781 |
| U-Taniguchi Y et al. | Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. | 1995 | Oncol. Res. | pmid:8555652 |
| Grimes PE | Melasma. Etiologic and therapeutic considerations. | 1995 | Arch Dermatol | pmid:7492140 |
| Lemic-Stojcevic L et al. | Effect of azelaic acid on melanoma cells in culture. | 1995 | Exp. Dermatol. | pmid:7640879 |
| Gatti R et al. | Analysis of aliphatic dicarboxylic acids in pharmaceuticals and cosmetics by liquid chromatography (HPLC) with fluorescence detection. | 1995 | J Pharm Biomed Anal | pmid:9696574 |
| Addo-Boadu K et al. | Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. | 1996 | Cancer Lett. | pmid:8635147 |
| Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
| Gibson JR | Rationale for the development of new topical treatments for acne vulgaris. | 1996 | Cutis | pmid:8654127 |
| Graupe K et al. | Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. | 1996 | Cutis | pmid:8654128 |
| Breathnach AS | Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. | 1996 | Cutis | pmid:8654129 |
| Lowe NJ | New approaches in dermatology: a clinical profile of azelaic acid. | 1996 | Cutis | pmid:8654130 |
| Nazzaro-Porro M et al. | A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. | 1996 | Clin. Exp. Dermatol. | pmid:8959915 |
| Mackrides PS and Shaughnessy AF | Azelaic acid therapy for acne. | 1996 | Am Fam Physician | pmid:8961845 |
| Rodriguez-Vicente J et al. | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. | 1996 | Pigment Cell Res. | pmid:9125756 |
| Oh CW and Myung KB | An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. | 1996 | J. Dermatol. | pmid:8935627 |
| Jansen T and Plewig G | Advances and perspectives in acne therapy. | 1997 | Eur. J. Med. Res. | pmid:9262484 |
| Parsons PG et al. | Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells. | 1997 | Biochem. Pharmacol. | pmid:9264325 |
| Gibson JR | Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. | 1997 | Dermatol Nurs | pmid:9392765 |
| Rodriguez-Vicente J et al. | The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. | 1998 | Cancer | pmid:9452267 |
| Usatine RP et al. | Acne vulgaris: a treatment update. | 1998 | Hosp Pract (1995) | pmid:9484299 |
| Gollnick H and Schramm M | Topical drug treatment in acne. | 1998 | Dermatology (Basel) | pmid:9557245 |
| Gollnick H and Schramm M | Topical therapy in acne. | 1998 | J Eur Acad Dermatol Venereol | pmid:9891903 |
| Spellman MC and Pincus SH | Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. | 1998 Jul-Aug | Clin Ther | pmid:9737831 |
| Lowe NJ et al. | Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. | 1998 Sep-Oct | Clin Ther | pmid:9829446 |
| Kakita LS and Lowe NJ | Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. | 1998 Sep-Oct | Clin Ther | pmid:9829447 |
| Bjerke R et al. | Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea. | 1999 | Acta Derm. Venereol. | pmid:10598760 |
| Capristo E et al. | A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples. | 1999 | Clin. Chim. Acta | pmid:10556649 |
| Breathnach AS | Azelaic acid: potential as a general antitumoural agent. | 1999 | Med. Hypotheses | pmid:10362281 |
| Rocamora V et al. | Amelanotic lentigo maligna melanoma: report of a case and review of the literature. | 1999 | Cutis | pmid:10431675 |
| Maddin S | A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea. | 1999 | J. Am. Acad. Dermatol. | pmid:10365928 |
| Hermanns JF et al. | Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents. | 2000 | Dermatology (Basel) | pmid:11053913 |
| Korman SH et al. | Characteristic urine organic acid profile in peroxisomal biogenesis disorders. | 2000 | J. Inherit. Metab. Dis. | pmid:10896310 |
| Webster G | Combination azelaic acid therapy for acne vulgaris. | 2000 | J. Am. Acad. Dermatol. | pmid:10898830 |
| Russell JJ | Topical therapy for acne. | 2000 | Am Fam Physician | pmid:10670502 |
| Thiboutot D | New treatments and therapeutic strategies for acne. | 2000 | Arch Fam Med | pmid:10693736 |
| Usatine RP | The science and art of treating acne in adolescence. | 2000 | West. J. Med. | pmid:10734805 |
| Malaisse WJ et al. | Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets. | 2000 | Br. J. Nutr. | pmid:11177188 |
| Gutheil WG | Application of hierarchical thermodynamic interactions to the protonation equilibria of organic polyprotic acids. | 2000 | Biophys. Chem. | pmid:11152269 |
| Pérez-Bernal A et al. | Management of facial hyperpigmentation. | 2000 Sep-Oct | Am J Clin Dermatol | pmid:11702317 |
| Koczorek M | ["Cleansing, topical treatment, oral administration". Controlling acne]. | 2001 | MMW Fortschr Med | pmid:11524979 |
| Gollnick HP et al. | Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. | 2001 Nov-Dec | Eur J Dermatol | pmid:11701404 |
| Brune TG et al. | Unknown peaks in GC-MS analyses of Guthrie cards blood samples might be the result of sample contamination by the black markings of the card. | 2002 | J. Inherit. Metab. Dis. | pmid:12555947 |
| Del Rosso JQ | A status report on the medical management of rosacea: focus on topical therapies. | 2002 | Cutis | pmid:12469780 |
| Hojo Y et al. | Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. | 2002 | Circ. Res. | pmid:12386148 |
| Ruan H et al. | Structure of a novel diterpenoid ester, fritillahupehin from bulbs of Fritillaria hupehensis Hsiao and K.C. Hsia. | 2002 | Fitoterapia | pmid:12234570 |