| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pituitary Apoplexy | D010899 | 1 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Melanosis | D008548 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Keratosis | D007642 | 9 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Erythema | D004890 | 22 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gollnick H and Schramm M | Topical therapy in acne. | 1998 | J Eur Acad Dermatol Venereol | pmid:9891903 |
| Kakita LS and Lowe NJ | Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. | 1998 Sep-Oct | Clin Ther | pmid:9829447 |
| Lowe NJ et al. | Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. | 1998 Sep-Oct | Clin Ther | pmid:9829446 |
| Spellman MC and Pincus SH | Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. | 1998 Jul-Aug | Clin Ther | pmid:9737831 |
| Gatti R et al. | Analysis of aliphatic dicarboxylic acids in pharmaceuticals and cosmetics by liquid chromatography (HPLC) with fluorescence detection. | 1995 | J Pharm Biomed Anal | pmid:9696574 |
| Gollnick H and Schramm M | Topical drug treatment in acne. | 1998 | Dermatology (Basel) | pmid:9557245 |
| Usatine RP et al. | Acne vulgaris: a treatment update. | 1998 | Hosp Pract (1995) | pmid:9484299 |
| Rodriguez-Vicente J et al. | The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. | 1998 | Cancer | pmid:9452267 |
| Gibson JR | Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. | 1997 | Dermatol Nurs | pmid:9392765 |
| Parsons PG et al. | Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells. | 1997 | Biochem. Pharmacol. | pmid:9264325 |
| Jansen T and Plewig G | Advances and perspectives in acne therapy. | 1997 | Eur. J. Med. Res. | pmid:9262484 |
| Rodriguez-Vicente J et al. | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. | 1996 | Pigment Cell Res. | pmid:9125756 |
| Mackrides PS and Shaughnessy AF | Azelaic acid therapy for acne. | 1996 | Am Fam Physician | pmid:8961845 |
| Nazzaro-Porro M et al. | A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. | 1996 | Clin. Exp. Dermatol. | pmid:8959915 |
| Oh CW and Myung KB | An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. | 1996 | J. Dermatol. | pmid:8935627 |
| Lowe NJ | New approaches in dermatology: a clinical profile of azelaic acid. | 1996 | Cutis | pmid:8654130 |
| Breathnach AS | Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. | 1996 | Cutis | pmid:8654129 |
| Graupe K et al. | Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. | 1996 | Cutis | pmid:8654128 |
| Gibson JR | Rationale for the development of new topical treatments for acne vulgaris. | 1996 | Cutis | pmid:8654127 |
| Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
| Addo-Boadu K et al. | Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. | 1996 | Cancer Lett. | pmid:8635147 |
| U-Taniguchi Y et al. | Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. | 1995 | Oncol. Res. | pmid:8555652 |
| RodrÃguez Prieto MA et al. | Treatment of lentigo maligna with azelaic acid. | 1993 | Int. J. Dermatol. | pmid:8505164 |
| Brasch J and Christophers E | Azelaic acid has antimycotic properties in vitro. | 1993 | Dermatology (Basel) | pmid:8435518 |
| Gatti S and Nini G | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. | 1993 | J. Am. Acad. Dermatol. | pmid:8408814 |
| Azelaic acid--a new topical treatment for acne. | 1993 | Drug Ther Bull | pmid:8344141 | |
| Zhang EJ et al. | [Chemical constituents from the bark of Hibiscus syriacus L]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8323683 |
| Bojar RA et al. | Follicular concentrations of azelaic acid after a single topical application. | 1993 | Br. J. Dermatol. | pmid:8217752 |
| Pattarino F et al. | Topical delivery systems for azelaic acid: effect of the suspended drug in microemulsion. | 1994 | Pharmazie | pmid:8140138 |
| Banerjee S et al. | Proxyl nitroxide of lithocholic acid: a potential spin probe for model membranes. | 1993 | Bioorg. Med. Chem. | pmid:8081864 |
| Ferioli V et al. | Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization. | 1994 | Farmaco | pmid:8074784 |
| Banerjee S et al. | 2'-(3 alpha-Benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'- dihydrooxazoline-N-oxyl as a potential spin probe for model membranes. | 1994 | Steroids | pmid:7940616 |
| Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
| Nguyen QH and Bui TP | Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. | 1995 | Int. J. Dermatol. | pmid:7737781 |
| Grammatico P et al. | Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. | 1993 | Mutat. Res. | pmid:7685492 |
| Lemic-Stojcevic L et al. | Effect of azelaic acid on melanoma cells in culture. | 1995 | Exp. Dermatol. | pmid:7640879 |
| Grimes PE | Melasma. Etiologic and therapeutic considerations. | 1995 | Arch Dermatol | pmid:7492140 |
| Palassis J | The sampling and determination of azelaic acid in air. | 1978 | Am Ind Hyg Assoc J | pmid:727120 |
| Maru U et al. | [In vitro diffusion and skin penetration of azelaic preparations: study of correlations]. | 1982 May-Jun | J Pharm Belg | pmid:7131228 |
| Willshaw HE and Rubinstein K | Azelaic acid in the treatment of ocular and adnexal malignant melanoma. | 1983 | Br J Ophthalmol | pmid:6848136 |
| [Advances in pigment studies]. | 1983 | Hautarzt | pmid:6678891 | |
| Passi S et al. | Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631243 |
| Mingrone G et al. | Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. | 1984 | Exp Pathol | pmid:6539234 |
| Breathnach AS et al. | Azelaic acid. | 1984 | Br. J. Dermatol. | pmid:6234914 |
| Marsden JR and Shuster S | The effect of azelaic acid on acne. | 1983 | Br. J. Dermatol. | pmid:6228247 |
| Nazzaro-Porro M et al. | Beneficial effect of 15% azelaic acid cream on acne vulgaris. | 1983 | Br. J. Dermatol. | pmid:6222755 |
| Nazzaro-Porro M et al. | Effect of azelaic acid on human malignant melanoma. | 1980 | Lancet | pmid:6103442 |
| Solo AJ and Gardner JO | Agents for alkylating steroid hormone receptors. 3. Omega-substituted esters of 17-alpha-hydroxyprogesterone. | 1971 | J Pharm Sci | pmid:5115254 |
| Polis BD et al. | Studies on PGBx, a polymeric derivative of prostaglandin B1: I. Synthesis and purification of PGBx. | 1979 | Physiol. Chem. Phys. | pmid:482383 |
| Dousset N and Douste-Blazy L | [Azelaic acid transformation into monocarboxylic fatty acids in vivo in the rat]. | 1973 | Biochimie | pmid:4793585 |
| Nazzaro-Porro M et al. | Effect of dicarboxylic acids on lentigo maligna. | 1979 | J. Invest. Dermatol. | pmid:448162 |
| Robins EJ et al. | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. | 1985 | Br. J. Dermatol. | pmid:4096883 |
| Leibl H et al. | Inhibition of DNA synthesis of melanoma cells by azelaic acid. | 1985 | J. Invest. Dermatol. | pmid:4056455 |
| Pathak MA et al. | An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1985 | J. Invest. Dermatol. | pmid:4031538 |
| Robins EJ et al. | Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. | 1985 | J. Invest. Dermatol. | pmid:4031537 |
| Picardo M et al. | Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts. | 1985 | Biochem. Pharmacol. | pmid:4004885 |
| Rocchiccioli F et al. | Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. | 1986 | Pediatr. Res. | pmid:3945517 |
| Hu F et al. | Effects of dicarboxylic acids on normal and malignant melanocytes in culture. | 1986 | Br. J. Dermatol. | pmid:3942687 |
| Ortonne JP | [Depigmenting chemical agents]. | 1986 | Ann Dermatol Venereol | pmid:3800227 |
| Ward BJ et al. | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. | 1986 | J. Invest. Dermatol. | pmid:3745962 |
| Robins EJ et al. | Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. | 1986 | J. Invest. Dermatol. | pmid:3734479 |
| McLean DI and Peter KK | Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid. | 1986 | Br. J. Dermatol. | pmid:3718862 |
| Geier G et al. | [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. | 1986 | Hautarzt | pmid:3700102 |
| Grosshans E and Chartier C | [Therapeutic depigmentation agents]. | 1987 | Schweiz. Rundsch. Med. Prax. | pmid:3671942 |
| Schallreuter KU and Wood JM | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. | 1987 | Cancer Lett. | pmid:3652030 |
| Azelaic acid in lentigo maligna. | 1987 | Br. J. Dermatol. | pmid:3580294 | |
| Sowden J et al. | Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid. | 1988 | Clin. Exp. Dermatol. | pmid:3256454 |
| Stamatiadis D et al. | Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. | 1988 | Br. J. Dermatol. | pmid:3207614 |
| Mingrone G et al. | Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro. | 1988 | Q J Exp Physiol | pmid:3164112 |
| Piquero MartÃn J et al. | [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. | 1988 | Med Cutan Ibero Lat Am | pmid:3073279 |
| Nazzaro-Porro M | Azelaic acid. | 1987 | J. Am. Acad. Dermatol. | pmid:2963038 |
| Auld J | Topical therapy of acne. | 1986 | Australas. J. Dermatol. | pmid:2957990 |
| Leeming JP et al. | The in vitro antimicrobial effect of azelaic acid. | 1986 | Br. J. Dermatol. | pmid:2947607 |
| Bladon PT et al. | Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. | 1986 | Br. J. Dermatol. | pmid:2938615 |
| Gassmueller H et al. | Azelaic acid and sebum excretion rate. | 1985 | Br. J. Dermatol. | pmid:2937439 |
| Daverat P et al. | Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. | 1989 | J. Neuroimmunol. | pmid:2925840 |
| Breathnach AS et al. | Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2925320 |
| pmid:29040817 | ||||
| pmid:28950768 | ||||
| pmid:28686770 | ||||
| pmid:28304135 | ||||
| pmid:28274355 | ||||
| pmid:28235481 | ||||
| Jorand JP et al. | The "survival hormones": azelaic and pimelic acids, suppress the stress elicited by isolation conditions on the steroids and phospholipids of adult worker honeybees. | 1989 | Horm. Metab. Res. | pmid:2807145 |
| pmid:27956183 | ||||
| pmid:27897372 | ||||
| pmid:27874885 | ||||
| Samycia M and Lam JM | Infantile acne. | 2016 | CMAJ | pmid:27873756 |
| pmid:27814413 | ||||
| Nüssgen AI et al. | Topographical analysis of proliferation ([3H]thymidine labelling index and mitotic index) as compared with tumour growth and tumour weight in xenotransplanted melanoma. Changes due to local and systemic application of azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773615 |
| Nazzaro-Porro M et al. | Ten years' experience of treating lentigo maligna with topical azelaic acid. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773614 |
| Azelaic acid: a new therapeutic agent. Proceedings of the CMD-satellite-symposium on azelaic acid. 17th World Congress of Dermatology. Berlin, May 1987. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2773613 | |
| Rigoni C et al. | [Use of a cream based on 20% azelaic acid in the treatment of melasma]. | 1989 Jan-Feb | G Ital Dermatol Venereol | pmid:2767714 |
| Lim GH et al. | Role of plasmodesmata and plasmodesmata localizing proteins in systemic immunity. | 2016 | Plant Signal Behav | pmid:27645210 |
| pmid:27500896 | ||||
| pmid:27484346 | ||||
| pmid:27417723 | ||||
| Helfrich YR and Maier LM | Topical and oral therapeutic approach to rosacea. | 2016 | Semin Cutan Med Surg | pmid:27416312 |
| pmid:27414241 | ||||
| pmid:27352185 |