Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

MeSH term MeSH ID Detail
Rosacea D012393 13 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Hutchinson's Melanotic Freckle D018327 2 associated lipids
Dermatitis, Perioral D019557 4 associated lipids
Pituitary ACTH Hypersecretion D047748 1 associated lipids
Disease Resistance D060467 12 associated lipids
Per page 10 20 50 | Total 27

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

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Authors Title Published Journal PubMed Link
Ziel K et al. Cumulative irritation potential of metronidazole gel compared to azelaic acid gel after repeated applications to healthy skin. 2005 Nov-Dec J Drugs Dermatol pmid:16302558
Sasmaz S and Arican O Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. 2005 Am J Clin Dermatol pmid:16343028
Nally JB and Berson DS Topical therapies for rosacea. 2006 J Drugs Dermatol pmid:16468288
Fleischer AB The evolution of azelaic acid. 2006 Cutis pmid:16566281
Draelos ZD The rationale for advancing the formulation of azelaic acid vehicles. 2006 Cutis pmid:16566282
Elewski B and Thiboutot D A clinical overview of azelaic acid. 2006 Cutis pmid:16566283
Bikowski JB Case studies. 2006 Cutis pmid:16566284
Del Rosso JQ The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. 2006 Cutis pmid:16566285
pmid:16631968
Worret WI and Fluhr JW [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. 2006 J Dtsch Dermatol Ges pmid:16638058
Wolf JE et al. Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. 2006 Cutis pmid:16706244
pmid:16737240
[Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991]. 1991 Hautarzt pmid:1674505
Hung HM et al. Products and mechanisms of the reaction of oleic acid with ozone and nitrate radical. 2005 J Phys Chem A pmid:16833788
Liu RH et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. 2006 Arch Dermatol pmid:16924055
Goodman G Managing acne vulgaris effectively. 2006 Aust Fam Physician pmid:16969442
Purdy S Acne vulgaris. 2006 Clin Evid pmid:16973084
pmid:17014483
Weschler CJ Ozone's impact on public health: contributions from indoor exposures to ozone and products of ozone-initiated chemistry. 2006 Environ. Health Perspect. pmid:17035131
Zhang JF et al. [Studies on chemical constituents in root tuber of Cynanchum auriculatum]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048663
Gupta AK et al. The treatment of melasma: a review of clinical trials. 2006 J. Am. Acad. Dermatol. pmid:17097400
Fitton A and Goa KL Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. 1991 Drugs pmid:1712709
pmid:17147560
Draelos ZD et al. An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients. 2006 J Cosmet Dermatol pmid:17173568
van Zuuren EJ et al. Systematic review of rosacea treatments. 2007 J. Am. Acad. Dermatol. pmid:17190628
Erbil H et al. Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. 2007 J. Dermatol. pmid:17204097
pmid:17249752
Bojar RA et al. The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. 1991 J. Antimicrob. Chemother. pmid:1726169
pmid:17268656
Hinz DC Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace. 2007 J Pharm Biomed Anal pmid:17280812
Stinco G et al. Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. 2007 J Eur Acad Dermatol Venereol pmid:17309452
Elewski BE Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. 2007 Cutis pmid:17330623
Del Rosso JQ et al. Azelaic acid gel 15%: clinical versatility in the treatment of rosacea. 2006 Cutis pmid:17354468
Nojima S et al. Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus. 2007 J. Chem. Ecol. pmid:17394050
pmid:17394294
Iraji F et al. Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. 2007 Mar-Apr Indian J Dermatol Venereol Leprol pmid:17456913
Gupta AK and Gover MD Azelaic acid (15% gel) in the treatment of acne rosacea. 2007 Int. J. Dermatol. pmid:17472690
Alevizos A et al. Acne treatments: consider these options--and issues. 2007 J Fam Pract pmid:17475157
Devereux M et al. Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). 2006 Bioinorg Chem Appl pmid:17497019
Colón LE et al. Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. 2007 Cutis pmid:17500380
pmid:17508766
Manosroi A et al. Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines. 2007 J Drug Target pmid:17541842
Satoh M et al. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. 2007 Circulation pmid:17562954
pmid:17566774
pmid:17622422
Prignano F et al. Therapeutical approaches in melasma. 2007 Dermatol Clin pmid:17662899
Conde JF et al. Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. 2007 J Drugs Dermatol pmid:17679183
Passi S et al. The oxyradical-scavenging activity of azelaic acid in biological systems. 1991 Free Radic. Res. Commun. pmid:1769610
Akman A et al. Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. 2007 Arch. Dermatol. Res. pmid:17710426
Elewski BE et al. In reference to the October 2004 comprehensive overview of rosacea therapy. 2007 J. Am. Acad. Dermatol. pmid:17870440
pmid:17927163
pmid:17931096
Herkenne C et al. In vivo methods for the assessment of topical drug bioavailability. 2008 Pharm. Res. pmid:17985216
pmid:18045355
Baliña LM and Graupe K The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. 1991 Int. J. Dermatol. pmid:1816137
Maher HK Rosacea. 2007 AAOHN J pmid:18183803
Arizaga GG et al. Chemical modification of zinc hydroxide nitrate and Zn-Al-layered double hydroxide with dicarboxylic acids. 2008 J Colloid Interface Sci pmid:18243238
Thiboutot D Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris. 2008 J Drugs Dermatol pmid:18246693
Chen Z et al. Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. 2008 J. Am. Chem. Soc. pmid:18278910
pmid:18280490
Kanitakis J Linea fusca in a male adolescent successfully treated with azelaic acid. 2008 J Eur Acad Dermatol Venereol pmid:18331308
pmid:18377339
Gollnick H [Azelaic acid for keratinization disorders?]. 1991 Med Monatsschr Pharm pmid:1838401
pmid:18394082
De Filippis D et al. Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. 2009 J. Cell. Mol. Med. pmid:18429935
Stewart JJ Application of the PM6 method to modeling the solid state. 2008 J Mol Model pmid:18449579
Piskin S and Uzunali E A review of the use of adapalene for the treatment of acne vulgaris. 2007 Ther Clin Risk Manag pmid:18472984
pmid:18535811
Thiboutot DM et al. Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea. 2008 J Drugs Dermatol pmid:18561584
Crea F et al. Sequestering ability of polycarboxylic ligands towards dioxouranium(VI). 2008 Talanta pmid:18585146
pmid:18641447
Akamatsu H et al. Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. 1991 Arch. Dermatol. Res. pmid:1867478
Mostafa FF et al. Comparative study of some treatment modalities of rosacea. 2009 J Eur Acad Dermatol Venereol pmid:18705632
pmid:18728922
Rup S et al. The ultrasound-assisted oxidative scission of monoenic fatty acids by ruthenium tetroxide catalysis: influence of the mixture of solvents. 2009 Ultrason Sonochem pmid:18799341
Gollnick H and Layton A Azelaic acid 15% gel in the treatment of rosacea. 2008 Expert Opin Pharmacother pmid:18803456
Lee GS Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: a short report. 2008 J Cosmet Laser Ther pmid:18830869
pmid:19022456
pmid:19055345
Bertuzzi A et al. Pharmacokinetic analysis of azelaic acid disodium salt. A proposed substrate for total parenteral nutrition. 1991 Clin Pharmacokinet pmid:1908756
pmid:19126734
pmid:19160531
Melnik BC et al. Anti-acne agents attenuate FGFR2 signal transduction in acne. 2009 J. Invest. Dermatol. pmid:19225542
Gooderham M Rosacea and its topical management. 2009 Skin Therapy Lett. pmid:19330270
Jung HW et al. Priming in systemic plant immunity. 2009 Science pmid:19342588
Del Rosso JQ et al. Impact of order of application of moisturizers on percutaneous absorption kinetics: evaluation of sequential application of moisturizer lotions and azelaic acid gel 15% using a human skin model. 2009 Cutis pmid:19363903
pmid:19433342
Parker JE The quest for long-distance signals in plant systemic immunity. 2009 Sci Signal pmid:19436056
Purdy S and Deberker D Acne vulgaris. 2008 BMJ Clin Evid pmid:19450306
pmid:19465852
Bowler PJ Impact on facial rejuvenation with dermatological preparations. 2009 Clin Interv Aging pmid:19503770
Korting HC and Schöllmann C Current topical and systemic approaches to treatment of rosacea. 2009 J Eur Acad Dermatol Venereol pmid:19508315
Culp B and Scheinfeld N Rosacea: a review. 2009 P T pmid:19562004
Thiboutot DM et al. A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy. 2009 J Drugs Dermatol pmid:19588640
pmid:19608057
Shah J Plants under attack: systemic signals in defence. 2009 Curr. Opin. Plant Biol. pmid:19608451
Lanz C et al. Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. 2009 Radiat. Res. pmid:19630524
pmid:19643540
Goldgar C et al. Treatment options for acne rosacea. 2009 Am Fam Physician pmid:19725487
Que SK and Bergstrom KG Hyperpigmentation: old problem, new therapies. 2009 J Drugs Dermatol pmid:19746682