Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Acne Keloid D000153 1 associated lipids
Alopecia Areata D000506 6 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Drug Eruptions D003875 30 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Erythema D004890 22 associated lipids
Facial Dermatoses D005148 7 associated lipids
Heart Failure D006333 36 associated lipids
Per page 10 20 50 | Total 27

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

Download all related citations
Per page 10 20 50 100 | Total 511
Authors Title Published Journal PubMed Link
Wolf JE Present and future rosacea therapy. 2005 Cutis pmid:15810803
van Zuuren EJ and Graber MA The rigor of trials evaluating Rosacea treatments. 2005 Cutis pmid:15810805
Sasmaz S and Arican O Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. 2005 Am J Clin Dermatol pmid:16343028
Kuster GM et al. Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. 2005 Circulation pmid:15723974
Punsalan T and Usatine RP Red facial rash with "granitos". 2005 J Fam Pract pmid:16144591
Roebuck HL Face up to rosacea. 2005 Nurse Pract pmid:16151303
Purdy S Acne vulgaris. 2005 Clin Evid pmid:16135322
Hung HM et al. Products and mechanisms of the reaction of oleic acid with ozone and nitrate radical. 2005 J Phys Chem A pmid:16833788
Shirokova E et al. Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. 2005 J. Biol. Chem. pmid:15598656
Ziel K et al. Cumulative irritation potential of metronidazole gel compared to azelaic acid gel after repeated applications to healthy skin. 2005 Nov-Dec J Drugs Dermatol pmid:16302558
Fleischer A and Suephy C The face and mind evaluation study: an examination of the efficacy of rosacea treatment using physician ratings and patients' self-reported quality of life. 2005 Sep-Oct J Drugs Dermatol pmid:16167417
Weschler CJ Ozone's impact on public health: contributions from indoor exposures to ozone and products of ozone-initiated chemistry. 2006 Environ. Health Perspect. pmid:17035131
Del Rosso JQ et al. Azelaic acid gel 15%: clinical versatility in the treatment of rosacea. 2006 Cutis pmid:17354468
Goodman G Managing acne vulgaris effectively. 2006 Aust Fam Physician pmid:16969442
Purdy S Acne vulgaris. 2006 Clin Evid pmid:16973084
Liu RH et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. 2006 Arch Dermatol pmid:16924055
Fleischer AB The evolution of azelaic acid. 2006 Cutis pmid:16566281
Draelos ZD The rationale for advancing the formulation of azelaic acid vehicles. 2006 Cutis pmid:16566282
Elewski B and Thiboutot D A clinical overview of azelaic acid. 2006 Cutis pmid:16566283
Bikowski JB Case studies. 2006 Cutis pmid:16566284
Del Rosso JQ The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. 2006 Cutis pmid:16566285
Nally JB and Berson DS Topical therapies for rosacea. 2006 J Drugs Dermatol pmid:16468288
Zhang JF et al. [Studies on chemical constituents in root tuber of Cynanchum auriculatum]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048663
Gupta AK et al. The treatment of melasma: a review of clinical trials. 2006 J. Am. Acad. Dermatol. pmid:17097400
Worret WI and Fluhr JW [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. 2006 J Dtsch Dermatol Ges pmid:16638058
Wolf JE et al. Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. 2006 Cutis pmid:16706244
Draelos ZD et al. An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients. 2006 J Cosmet Dermatol pmid:17173568
Devereux M et al. Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). 2006 Bioinorg Chem Appl pmid:17497019
Akman A et al. Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. 2007 Arch. Dermatol. Res. pmid:17710426
Elewski BE Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. 2007 Cutis pmid:17330623
Stinco G et al. Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. 2007 J Eur Acad Dermatol Venereol pmid:17309452
Nojima S et al. Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus. 2007 J. Chem. Ecol. pmid:17394050
Hinz DC Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace. 2007 J Pharm Biomed Anal pmid:17280812
Manosroi A et al. Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines. 2007 J Drug Target pmid:17541842
Satoh M et al. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. 2007 Circulation pmid:17562954
Colón LE et al. Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. 2007 Cutis pmid:17500380
Gupta AK and Gover MD Azelaic acid (15% gel) in the treatment of acne rosacea. 2007 Int. J. Dermatol. pmid:17472690
Alevizos A et al. Acne treatments: consider these options--and issues. 2007 J Fam Pract pmid:17475157
Conde JF et al. Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. 2007 J Drugs Dermatol pmid:17679183
Prignano F et al. Therapeutical approaches in melasma. 2007 Dermatol Clin pmid:17662899
Maher HK Rosacea. 2007 AAOHN J pmid:18183803
Piskin S and Uzunali E A review of the use of adapalene for the treatment of acne vulgaris. 2007 Ther Clin Risk Manag pmid:18472984
Elewski BE et al. In reference to the October 2004 comprehensive overview of rosacea therapy. 2007 J. Am. Acad. Dermatol. pmid:17870440
van Zuuren EJ et al. Systematic review of rosacea treatments. 2007 J. Am. Acad. Dermatol. pmid:17190628
Erbil H et al. Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. 2007 J. Dermatol. pmid:17204097
Iraji F et al. Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. 2007 Mar-Apr Indian J Dermatol Venereol Leprol pmid:17456913
Lee GS Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: a short report. 2008 J Cosmet Laser Ther pmid:18830869
Thiboutot D Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris. 2008 J Drugs Dermatol pmid:18246693
Kanitakis J Linea fusca in a male adolescent successfully treated with azelaic acid. 2008 J Eur Acad Dermatol Venereol pmid:18331308
Chen Z et al. Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. 2008 J. Am. Chem. Soc. pmid:18278910