| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Acne Keloid | D000153 | 1 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Webster G | Combination azelaic acid therapy for acne vulgaris. | 2000 | J. Am. Acad. Dermatol. | pmid:10898830 |
| Coda AB et al. | Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. | 2013 | J. Am. Acad. Dermatol. | pmid:23871720 |
| Gatti S and Nini G | Treatment of reticulate acropigmentation of Kitamura with azelaic acid. | 1993 | J. Am. Acad. Dermatol. | pmid:8408814 |
| Chen Z et al. | Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. | 2008 | J. Am. Chem. Soc. | pmid:18278910 |
| Bojar RA et al. | The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37. | 1991 | J. Antimicrob. Chemother. | pmid:1726169 |
| Maple PA et al. | Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulphadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. | 1992 | J. Antimicrob. Chemother. | pmid:1506349 |
| Bojar RA et al. | Disruption of the transmembrane pH gradient--a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. | 1994 | J. Antimicrob. Chemother. | pmid:7829407 |
| Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
| Gołębiowski M et al. | Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. | 2014 | J. Appl. Microbiol. | pmid:24238211 |
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| Shirokova E et al. | Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. | 2005 | J. Biol. Chem. | pmid:15598656 |
| Yu JS and Kim AK | Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells. | 2010 | J. Biomed. Sci. | pmid:20804622 |
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| Nojima S et al. | Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus. | 2007 | J. Chem. Ecol. | pmid:17394050 |
| Yoon TY et al. | A case of idiopathic eruptive macular pigmentation. | 2004 | J. Dermatol. | pmid:15187318 |
| Erbil H et al. | Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. | 2007 | J. Dermatol. | pmid:17204097 |
| Oh CW and Myung KB | An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. | 1996 | J. Dermatol. | pmid:8935627 |
| Wittek F et al. | Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. | 2014 | J. Exp. Bot. | pmid:25114016 |
| Chae K et al. | A multifaceted study of stigma/style cysteine-rich adhesin (SCA)-like Arabidopsis lipid transfer proteins (LTPs) suggests diversified roles for these LTPs in plant growth and reproduction. | 2010 | J. Exp. Bot. | pmid:20667964 |
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| Brune TG et al. | Unknown peaks in GC-MS analyses of Guthrie cards blood samples might be the result of sample contamination by the black markings of the card. | 2002 | J. Inherit. Metab. Dis. | pmid:12555947 |
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| Robins EJ et al. | Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture. | 1985 | J. Invest. Dermatol. | pmid:4031537 |
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| Daverat P et al. | Identification and characterization of anti-conjugated azelaic acid antibodies in multiple sclerosis. | 1989 | J. Neuroimmunol. | pmid:2925840 |
| Cluzeau J and Lubell WD | Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate. | 2004 | J. Org. Chem. | pmid:14987004 |
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| Tacchino RM et al. | Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry. | 1990 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:2112625 |
| Mingrone G et al. | Preliminary studies of a dicarboxylic acid as an energy substrate in man. | 1989 May-Jun | JPEN J Parenter Enteral Nutr | pmid:2503641 |
| Nazzaro-Porro M et al. | Effect of azelaic acid on human malignant melanoma. | 1980 | Lancet | pmid:6103442 |
| Azelaic acid, a new treatment for rosacea. | 2004 | Mayo Clin Womens Healthsource | pmid:15152174 | |
| Piquero MartÃn J et al. | [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. | 1988 | Med Cutan Ibero Lat Am | pmid:3073279 |
| Azelaic acid (Finacea) for rosacea. | 2003 | Med Lett Drugs Ther | pmid:12968125 | |
| Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
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| Breathnach AS | Azelaic acid: potential as a general antitumoural agent. | 1999 | Med. Hypotheses | pmid:10362281 |