| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
| Wang C et al. | Free radicals mediate systemic acquired resistance. | 2014 | Cell Rep | pmid:24726369 |
| Shariff A et al. | Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. | 2014 | Dermatol. Online J. | pmid:24656277 |
| pmid:24591049 | ||||
| Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
| Draelos ZD et al. | Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study. | 2013 | Cutis | pmid:24416747 |
| Mayer-da Silva A et al. | Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. | 1987 | Acta Derm. Venereol. | pmid:2438874 |
| Vargas-Diez E et al. | Azelaic acid in the treatment of acne in adult females: case reports. | 2014 | Skin Pharmacol Physiol | pmid:24280645 |
| Sieber MA and Hegel JK | Azelaic acid: Properties and mode of action. | 2014 | Skin Pharmacol Physiol | pmid:24280644 |
| Gołębiowski M et al. | Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. | 2014 | J. Appl. Microbiol. | pmid:24238211 |
| Han S et al. | Application of HPLC with ELSD detection for the assessment of azelaic acid impurities in liposomal formulation. | 2013 | ScientificWorldJournal | pmid:24228008 |
| Zheng P et al. | A novel urinary metabolite signature for diagnosing major depressive disorder. | 2013 | J. Proteome Res. | pmid:24224655 |
| Han S et al. | Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS. | 2014 | AAPS PharmSciTech | pmid:24166667 |
| von Schönfels W et al. | Metabolic signature of electrosurgical liver dissection. | 2013 | PLoS ONE | pmid:24058442 |
| Alzweiri M et al. | Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker. | 2013 | J Sep Sci | pmid:23893928 |
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| Woolery-Lloyd HC et al. | Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. | 2013 | J Drugs Dermatol | pmid:23652891 |
| Yu K et al. | A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity. | 2013 | Cell Rep | pmid:23602565 |
| Jackson JM et al. | Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea. | 2013 | J Drugs Dermatol | pmid:23545911 |
| Reis CP et al. | Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. | 2014 | Drug Dev Ind Pharm | pmid:23480566 |
| Quigley EA and Halpern AC | Microinvasive melanoma: cutaneous pharmacotherapeutic approaches. | 2013 | Am J Clin Dermatol | pmid:23479385 |
| Bayerl C | [Acne therapy in pregnancy]. | 2013 | Hautarzt | pmid:23430167 |
| Muthulakshmi S and Saravanan R | Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice. | 2013 | Biochimie | pmid:23402910 |
| Shalita AR et al. | Inflammatory acne management with a novel prescription dietary supplement. | 2012 | J Drugs Dermatol | pmid:23377512 |
| Chauhan N and Ellis DA | Rosacea: pathophysiology and management principles. | 2013 | Facial Plast Surg Clin North Am | pmid:23369595 |
| Muthulakshmi S and Saravanan R | Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice. | 2013 | Mol. Cell. Biochem. | pmid:23361364 |
| Briganti S et al. | Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. | 2013 | Exp. Dermatol. | pmid:23278893 |
| Fallen RS and Gooderham M | Rosacea: update on management and emerging therapies. | 2012 | Skin Therapy Lett. | pmid:23223767 |
| Pazoki-Toroudi H et al. | Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia. | 2012 Sep-Oct | Skinmed | pmid:23163069 |
| Matsubara T et al. | Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. | 2012 | Cell Metab. | pmid:23140643 |
| Wilkerson MG and Wilkin JK | Azelaic acid esters do not depigment pigmented guinea pig skin. | 1990 | Arch Dermatol | pmid:2301969 |
| Simonart T | Newer approaches to the treatment of acne vulgaris. | 2012 | Am J Clin Dermatol | pmid:22920095 |
| Maes M et al. | Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression. | 2013 | J Affect Disord | pmid:22898471 |
| Zaffaroni N et al. | Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. | 1990 Nov-Dec | Anticancer Res. | pmid:2285231 |
| pmid:22849351 | ||||
| Zoeller M et al. | Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid. | 2012 | Plant Physiol. | pmid:22822212 |
| Wang H et al. | [Chemical constituents of Halenia elliptica]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22779176 |
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| Sarkar R et al. | Newer and upcoming therapies for melasma. | 2012 Jul-Aug | Indian J Dermatol Venereol Leprol | pmid:22772611 |
| pmid:22747347 | ||||
| Rozema E et al. | Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22675394 |
| Zhao H et al. | Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome. | 2012 | Evid Based Complement Alternat Med | pmid:22675387 |
| Cuevas P et al. | Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea. | 2011 | BMJ Case Rep | pmid:22675033 |
| Lorenc-Kukula K et al. | Biochemical and Molecular-Genetic Characterization of SFD1's Involvement in Lipid Metabolism and Defense Signaling. | 2012 | Front Plant Sci | pmid:22645576 |
| Reinholz M et al. | Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. | 2012 | Ann Dermatol | pmid:22577261 |
| Fabbrocini G et al. | Skin needling to enhance depigmenting serum penetration in the treatment of melasma. | 2011 | Plast Surg Int | pmid:22567235 |
| Garelnabi M et al. | Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples. | 2010 | N Am J Med Sci | pmid:22558586 |