Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

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Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

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Authors Title Published Journal PubMed Link
Parodi A et al. Treatment of rosacea. 2011 Ann Dermatol Venereol pmid:22183101
Vinaixa M et al. Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. 2011 PLoS ONE pmid:22194988
pmid:22226365
Verma P and Pathak K Therapeutic and cosmeceutical potential of ethosomes: An overview. 2010 J Adv Pharm Technol Res pmid:22247858
pmid:22268388
Park SY et al. The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus. 2012 Ann Dermatol pmid:22363153
Wang HW et al. Insight into the molecular evolution of non-specific lipid transfer proteins via comparative analysis between rice and sorghum. 2012 DNA Res. pmid:22368182
Chaturvedi R et al. An abietane diterpenoid is a potent activator of systemic acquired resistance. 2012 Plant J. pmid:22385469
Hsieh PW et al. The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin. 2012 Eur J Pharm Biopharm pmid:22469554
Aytekin M et al. Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery. 2013 Drug Dev Ind Pharm pmid:22480294
Estronca LM et al. Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model. 2012 PLoS ONE pmid:22514671
Garelnabi M et al. Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples. 2010 N Am J Med Sci pmid:22558586
Fabbrocini G et al. Skin needling to enhance depigmenting serum penetration in the treatment of melasma. 2011 Plast Surg Int pmid:22567235
Reinholz M et al. Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. 2012 Ann Dermatol pmid:22577261
Lorenc-Kukula K et al. Biochemical and Molecular-Genetic Characterization of SFD1's Involvement in Lipid Metabolism and Defense Signaling. 2012 Front Plant Sci pmid:22645576
Cuevas P et al. Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea. 2011 BMJ Case Rep pmid:22675033
Zhao H et al. Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome. 2012 Evid Based Complement Alternat Med pmid:22675387
Rozema E et al. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. 2012 Evid Based Complement Alternat Med pmid:22675394
pmid:22747347
Sarkar R et al. Newer and upcoming therapies for melasma. 2012 Jul-Aug Indian J Dermatol Venereol Leprol pmid:22772611
Bhatia ND and Del Rosso JQ Optimal management of papulopustular rosacea: rationale for combination therapy. 2012 J Drugs Dermatol pmid:22777226
Wang H et al. [Chemical constituents of Halenia elliptica]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22779176
Zoeller M et al. Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid. 2012 Plant Physiol. pmid:22822212
pmid:22849351
Zaffaroni N et al. Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. 1990 Nov-Dec Anticancer Res. pmid:2285231
Maes M et al. Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression. 2013 J Affect Disord pmid:22898471
Simonart T Newer approaches to the treatment of acne vulgaris. 2012 Am J Clin Dermatol pmid:22920095
Wilkerson MG and Wilkin JK Azelaic acid esters do not depigment pigmented guinea pig skin. 1990 Arch Dermatol pmid:2301969
Matsubara T et al. Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. 2012 Cell Metab. pmid:23140643
Pazoki-Toroudi H et al. Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia. 2012 Sep-Oct Skinmed pmid:23163069
Fallen RS and Gooderham M Rosacea: update on management and emerging therapies. 2012 Skin Therapy Lett. pmid:23223767
Briganti S et al. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. 2013 Exp. Dermatol. pmid:23278893
Muthulakshmi S and Saravanan R Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice. 2013 Mol. Cell. Biochem. pmid:23361364
Chauhan N and Ellis DA Rosacea: pathophysiology and management principles. 2013 Facial Plast Surg Clin North Am pmid:23369595
Shalita AR et al. Inflammatory acne management with a novel prescription dietary supplement. 2012 J Drugs Dermatol pmid:23377512
Muthulakshmi S and Saravanan R Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice. 2013 Biochimie pmid:23402910
Bayerl C [Acne therapy in pregnancy]. 2013 Hautarzt pmid:23430167
Quigley EA and Halpern AC Microinvasive melanoma: cutaneous pharmacotherapeutic approaches. 2013 Am J Clin Dermatol pmid:23479385
Reis CP et al. Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. 2014 Drug Dev Ind Pharm pmid:23480566
Jackson JM et al. Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea. 2013 J Drugs Dermatol pmid:23545911
Yu K et al. A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity. 2013 Cell Rep pmid:23602565
Woolery-Lloyd HC et al. Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. 2013 J Drugs Dermatol pmid:23652891
Reis CP et al. Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles. 2013 Microsc. Microanal. pmid:23673203
Schöfer H [Topical therapy of rosacea]. 2013 Hautarzt pmid:23780475
Melnik BC and Schmitz G Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? 2013 Exp. Dermatol. pmid:23800068
Coda AB et al. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. 2013 J. Am. Acad. Dermatol. pmid:23871720
Alzweiri M et al. Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker. 2013 J Sep Sci pmid:23893928
von Schönfels W et al. Metabolic signature of electrosurgical liver dissection. 2013 PLoS ONE pmid:24058442
Han S et al. Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS. 2014 AAPS PharmSciTech pmid:24166667
Zheng P et al. A novel urinary metabolite signature for diagnosing major depressive disorder. 2013 J. Proteome Res. pmid:24224655